APR00379G

antibody from Leading Biology

Targeting: CCNF FBX1, FBXO1

Western blot (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

APR00379G

Provider

Leading Biology

Product name

Cyclin F Antibody

Antibody type

Polyclonal

Description

Cyclin F is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is ubiquitously expressed in human cells but fluctuates dramatically through the cell cycle, peaking in G2 like cyclin A and decreasing prior to decline of cyclin B. Cyclin F exhibits regulated subcellular localization, being localized in the nucleus in most cells, with a significant percentage of cells showing only perinuclear staining.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.