TULP3

This gene encodes a member of the tubby gene family of bipartite transcription factors. Members of this family have been identified in plants, vertebrates, and invertebrates, and they share a conserved N-terminal transcription activation region and a conserved C-terminal DNA and phosphatidylinositol-phosphate binding region. The encoded protein binds to phosphoinositides in the plasma membrane via its C-terminal region and probably functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis, for instance, induced by G-protein-coupled-receptor signaling. It plays an important role in neuronal development and function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2009]

Description

TUB like protein 3

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nucleoli, Plasma membrane

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

12 (2877223 - 2941138)

Ensembl ID

ENSG00000078246  (ver. 103.38)

Orthologs

Mouse Tulp3: ENSMUSG00000001521

UniProt

O75386

neXtProt

NX_O75386

Human splice variants
Mouse splice variants

Protein structure