TLR6

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations. [provided by RefSeq, Jan 2011]

Description

Toll like receptor 6

Tissue specificity

Tissue enhanced (lymphoid tissue)

Subcell location

Endoplasmic reticulum

Predicted location

Membrane

Protein family

CD markers
Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

4 (38823715 - 38856817)

Ensembl ID

ENSG00000174130  (ver. 103.38)

Orthologs

Mouse Tlr6: ENSMUSG00000051498

UniProt

Q9Y2C9

neXtProt

NX_Q9Y2C9

Human splice variants
Mouse splice variants

Protein structure