CABT-L744

antibody from Creative Diagnostics

Targeting: TNFAIP3 A20, OTUD7C

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Antibody Data

Product number

CABT-L744

Provider

Creative Diagnostics

Product name

Rabbit Anti-Human TNFAIP3 monoclonal antibody, clone TO18-42

Antibody type

Monoclonal

Description

A20 is a Cys2/Cys2 zinc finger protein that is induced by a variety of inflammatory stimuli and regulates gene expression. Specifically, A20 is induced by tumor necrosis factor (TNF) and interleukin 1 (IL-1), and acts as a negative regulator of nuclear factor °Ù B (NF°ÙB) gene expression. By inhibiting NF°ÙB activation, A20 plays a critical role in terminating NF°ÙB responses to various stimuli. Although the C-terminal region of A20 contains seven zinc finger domains, only four of these domains are required for in vitro inhibition of TNF-induced NF°ÙB activation. A20 also interacts with several other proteins, such as TRAF2, TRAF6 and I°ÙB kinase (IKK) ÎÛ protein, and can thereby inhibit cell death. TXBP151, a novel A20-binding protein, may mediate the anti-apoptotic activity of A20. Involved in the negative feedback regulation of signal transduction, A20 and A20-binding proteins may be useful as novel therapeutic tools in the treatment of a variety of diseases.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

TO18-42

Vial size

100 _l

Storage

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.