CABT-B9240

antibody from Creative Diagnostics

Targeting: DUSP4 HVH2, MKP-2, TYP

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

CABT-B9240

Provider

Creative Diagnostics

Product name

Mouse anti-Rat MKP2 monoclonal antibody, clone 59/NLQ3

Antibody type

Monoclonal

Description

The mitogen activated protein (MAP) kinases mediate signal transduction pathways involved in cellular growth and differentiation. These MAP kinases, including ERK1 and ERK2, are activated by phosphorylation on Tyr and Thr by MEK (MAP and ERK Kinase). Regulation of the resulting physiological effects of MAP Kinase activation is affected in part by MAP Kinase phosphatases (MKPs). These phosphatases have dual specificity, dephosphorylating both the tyrosine and threonine residues on MAP kinases. MKP2, which is widely expressed in human tissues, specifically dephosphorylates activated ERKs and JNK. These phosphatases have overlapping substrate specificities for the three known families of MAP kinases - p38, ERK, and JNK. All of the known MKPs contain a highly conserved carboxyl-terminal catalytic domain flanked by two CH2 (CDC25 homology 2) domains.

Reactivity

Human, Mouse, Rat

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

59/NLQ3

Vial size

50 _g

Concentration

250 Ã×g/ml

Storage

Store undiluted at -20°C.