Antibody data
- Antibody Data
- Antigen structure
- References [45]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 24206-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- DNMT1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated DNMT1 antibody (Cat. #24206-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Simultaneous silencing Aurora-A and UHRF1 inhibits colorectal cancer cell growth through regulating expression of DNMT1 and STAT1.
Inhibition of DNMT-1 alleviates ferroptosis through NCOA4 mediated ferritinophagy during diabetes myocardial ischemia/reperfusion injury.
DNMT1-induced miR-378a-3p silencing promotes angiogenesis via the NF-κB signaling pathway by targeting TRAF1 in hepatocellular carcinoma.
Detection of the level of DNMT1 based on self-assembled probe signal amplification technique in plasma.
8a, a New Acridine Antiproliferative and Pro-Apoptotic Agent Targeting HDAC1/DNMT1.
Melatonin inhibits lipid accumulation to repress prostate cancer progression by mediating the epigenetic modification of CES1.
Mechanical force inhibited hPDLSCs proliferation with the downregulation of MIR31HG via DNA methylation.
Huaier Inhibits Proliferation, Migration, and Invasion of Cutaneous Squamous Cell Carcinoma Cells by Inhibiting the Methylation Levels of CDKN2A and TP53.
DNMT1-Induced miR-152-3p Suppression Facilitates Cardiac Fibroblast Activation in Cardiac Fibrosis.
DNMT1-mediated PPARα methylation aggravates damage of retinal tissues in diabetic retinopathy mice.
NNK-mediated upregulation of DEPDC1 stimulates the progression of oral squamous cell carcinoma by inhibiting CYP27B1 expression.
SMYD2 suppresses APC2 expression to activate the Wnt/β-catenin pathway and promotes epithelial-mesenchymal transition in colorectal cancer.
Small Molecule Inhibitor C188-9 Synergistically Enhances the Demethylated Activity of Low-Dose 5-Aza-2'-Deoxycytidine Against Pancreatic Cancer.
Neuroprotective Effect of Piracetam against Cocaine-Induced Neuro Epigenetic Modification of DNA Methylation in Astrocytes.
Oxidative stress mediates the apoptosis and epigenetic modification of the Bcl-2 promoter via DNMT1 in a cigarette smoke-induced emphysema model.
Long noncoding RNA PVT1 promoted gallbladder cancer proliferation by epigenetically suppressing miR-18b-5p via DNA methylation.
Hydrogen sulfide rescues high glucose-induced migration dysfunction in HUVECs by upregulating miR-126-3p.
Grandmaternal betaine supplementation enhances hepatic IGF2 expression in F2 rat offspring through modification of promoter DNA methylation.
Dietary betaine improves egg-laying rate in hens through hypomethylation and glucocorticoid receptor-mediated activation of hepatic lipogenesis-related genes.
Maternal betaine supplementation decreases hepatic cholesterol deposition in chicken offspring with epigenetic modulation of SREBP2 and CYP7A1 genes.
Radiation-Induced DNMT3B Promotes Radioresistance in Nasopharyngeal Carcinoma through Methylation of p53 and p21.
Nanosecond pulsed electric fields enhance mesenchymal stem cells differentiation via DNMT1-regulated OCT4/NANOG gene expression.
Transgenerational Inheritance of Betaine-Induced Epigenetic Alterations in Estrogen-Responsive IGF-2/IGFBP2 Genes in Rat Hippocampus.
ACADS acts as a potential methylation biomarker associated with the proliferation and metastasis of hepatocellular carcinomas.
LncRNA NKILA regulates endothelium inflammation by controlling a NF-κB/KLF4 positive feedback loop.
Homocysteine impairs porcine oocyte quality via deregulation of one-carbon metabolism and hypermethylation of mitochondrial DNA†.
Dietary betaine activates hepatic VTGII expression in laying hens associated with hypomethylation of GR gene promoter and enhanced GR expression.
Dietary betaine supplementation in hens modulates hypothalamic expression of cholesterol metabolic genes in F1 cockerels through modification of DNA methylation.
Phosphatidylinositol 3-Kinase-DNA Methyltransferase 1-miR-1281-Histone Deacetylase 4 Regulatory Axis Mediates Platelet-Derived Growth Factor-Induced Proliferation and Migration of Pulmonary Artery Smooth Muscle Cells.
Mitotically Stable Modification of DNA Methylation in IGF2/H19 Imprinting Control Region Is Associated with Activated Hepatic IGF2 Expression in Offspring Rats from Betaine-Supplemented Dams.
Corticosterone-Induced Lipogenesis Activation and Lipophagy Inhibition in Chicken Liver Are Alleviated by Maternal Betaine Supplementation.
Mechanism of prolactin inhibition of miR-135b via methylation in goat mammary epithelial cells.
Melatonin-induced increase of lipid droplets accumulation and in vitro maturation in porcine oocytes is mediated by mitochondrial quiescence.
The inhibition of UBC13 expression and blockage of the DNMT1-CHFR-Aurora A pathway contribute to paclitaxel resistance in ovarian cancer.
In Vivo Ovarian Cancer Gene Therapy Using CRISPR-Cas9.
Maternal betaine administration modulates hepatic type 1 iodothyronine deiodinase (Dio1) expression in chicken offspring through epigenetic modifications.
Regulatory Axis of miR-195/497 and HMGA1-Id3 Governs Muscle Cell Proliferation and Differentiation.
Epigenetic modification differences between fetal fibroblast cells and mesenchymal stem cells of the Arbas Cashmere goat.
Prenatal betaine exposure modulates hypothalamic expression of cholesterol metabolic genes in cockerels through modifications of DNA methylation.
The synthetic antihyperlipidemic drug potassium piperate selectively kills breast cancer cells through inhibiting G1-S-phase transition and inducing apoptosis.
Abnormally activated one-carbon metabolic pathway is associated with mtDNA hypermethylation and mitochondrial malfunction in the oocytes of polycystic gilt ovaries.
HIC1 epigenetically represses CIITA transcription in B lymphocytes.
miR-148a-3p represses proliferation and EMT by establishing regulatory circuits between ERBB3/AKT2/c-myc and DNMT1 in bladder cancer.
In Ovo injection of betaine affects hepatic cholesterol metabolism through epigenetic gene regulation in newly hatched chicks.
Dietary betaine supplementation to gestational sows enhances hippocampal IGF2 expression in newborn piglets with modified DNA methylation of the differentially methylated regions.
Han J, Chen X, Xu J, Chu L, Li R, Sun N, Jiang Z, Liu H, Ge X, Zheng J, Yang J, Ikezoe T
International journal of medical sciences 2021;18(15):3437-3451
International journal of medical sciences 2021;18(15):3437-3451
Inhibition of DNMT-1 alleviates ferroptosis through NCOA4 mediated ferritinophagy during diabetes myocardial ischemia/reperfusion injury.
Li W, Li W, Wang Y, Leng Y, Xia Z
Cell death discovery 2021 Sep 29;7(1):267
Cell death discovery 2021 Sep 29;7(1):267
DNMT1-induced miR-378a-3p silencing promotes angiogenesis via the NF-κB signaling pathway by targeting TRAF1 in hepatocellular carcinoma.
Zhu B, Chen JJ, Feng Y, Yang JL, Huang H, Chung WY, Hu YL, Xue WJ
Journal of experimental & clinical cancer research : CR 2021 Nov 8;40(1):352
Journal of experimental & clinical cancer research : CR 2021 Nov 8;40(1):352
Detection of the level of DNMT1 based on self-assembled probe signal amplification technique in plasma.
Wan Z, Gong F, Zhang M, He L, Wang Y, Yu S, Liu J, Wu Y, Liu L, Wu Y, Qu L, Sun J, Yu F
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 2021 Nov 15;261:120020
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 2021 Nov 15;261:120020
8a, a New Acridine Antiproliferative and Pro-Apoptotic Agent Targeting HDAC1/DNMT1.
Zhang Q, Wang Z, Chen X, Qiu H, Gu Y, Wang N, Wang T, Wang Z, Ma H, Zhao Y, Zhang B
International journal of molecular sciences 2021 May 24;22(11)
International journal of molecular sciences 2021 May 24;22(11)
Melatonin inhibits lipid accumulation to repress prostate cancer progression by mediating the epigenetic modification of CES1.
Zhou L, Zhang C, Yang X, Liu L, Hu J, Hou Y, Tao H, Sugimura H, Chen Z, Wang L, Chen K
Clinical and translational medicine 2021 Jun;11(6):e449
Clinical and translational medicine 2021 Jun;11(6):e449
Mechanical force inhibited hPDLSCs proliferation with the downregulation of MIR31HG via DNA methylation.
Han Y, Yang Q, Huang Y, Li X, Zhu Y, Jia L, Zheng Y, Li W
Oral diseases 2021 Jul;27(5):1268-1282
Oral diseases 2021 Jul;27(5):1268-1282
Huaier Inhibits Proliferation, Migration, and Invasion of Cutaneous Squamous Cell Carcinoma Cells by Inhibiting the Methylation Levels of CDKN2A and TP53.
Wang L, Xu L, Wang Y
Integrative cancer therapies 2021 Jan-Dec;20:15347354211031646
Integrative cancer therapies 2021 Jan-Dec;20:15347354211031646
DNMT1-Induced miR-152-3p Suppression Facilitates Cardiac Fibroblast Activation in Cardiac Fibrosis.
Xu SS, Ding JF, Shi P, Shi KH, Tao H
Cardiovascular toxicology 2021 Dec;21(12):984-999
Cardiovascular toxicology 2021 Dec;21(12):984-999
DNMT1-mediated PPARα methylation aggravates damage of retinal tissues in diabetic retinopathy mice.
Zhu Y, Wang X, Zhou X, Ding L, Liu D, Xu H
Biological research 2021 Aug 6;54(1):25
Biological research 2021 Aug 6;54(1):25
NNK-mediated upregulation of DEPDC1 stimulates the progression of oral squamous cell carcinoma by inhibiting CYP27B1 expression.
Guo J, Zhou S, Huang P, Xu S, Zhang G, He H, Zeng Y, Xu CX, Kim H, Tan Y
American journal of cancer research 2020;10(6):1745-1760
American journal of cancer research 2020;10(6):1745-1760
SMYD2 suppresses APC2 expression to activate the Wnt/β-catenin pathway and promotes epithelial-mesenchymal transition in colorectal cancer.
Meng F, Liu X, Lin C, Xu L, Liu J, Zhang P, Zhang X, Song J, Yan Y, Ren Z, Zhang Y
American journal of cancer research 2020;10(3):997-1011
American journal of cancer research 2020;10(3):997-1011
Small Molecule Inhibitor C188-9 Synergistically Enhances the Demethylated Activity of Low-Dose 5-Aza-2'-Deoxycytidine Against Pancreatic Cancer.
Kong R, Sun G, Li X, Wu L, Li L, Li Y, Wang F, Xuan P, Yang S, Sun B, Hu J
Frontiers in oncology 2020;10:612
Frontiers in oncology 2020;10:612
Neuroprotective Effect of Piracetam against Cocaine-Induced Neuro Epigenetic Modification of DNA Methylation in Astrocytes.
Sivalingam K, Samikkannu T
Brain sciences 2020 Sep 5;10(9)
Brain sciences 2020 Sep 5;10(9)
Oxidative stress mediates the apoptosis and epigenetic modification of the Bcl-2 promoter via DNMT1 in a cigarette smoke-induced emphysema model.
Zeng H, Li T, He X, Cai S, Luo H, Chen P, Chen Y
Respiratory research 2020 Sep 3;21(1):229
Respiratory research 2020 Sep 3;21(1):229
Long noncoding RNA PVT1 promoted gallbladder cancer proliferation by epigenetically suppressing miR-18b-5p via DNA methylation.
Jin L, Cai Q, Wang S, Wang S, Wang J, Quan Z
Cell death & disease 2020 Oct 16;11(10):871
Cell death & disease 2020 Oct 16;11(10):871
Hydrogen sulfide rescues high glucose-induced migration dysfunction in HUVECs by upregulating miR-126-3p.
Xue WL, Chen RQ, Zhang QQ, Li XH, Cao L, Li MY, Li Y, Lin G, Chen Y, Wang MJ, Zhu YC
American journal of physiology. Cell physiology 2020 May 1;318(5):C857-C869
American journal of physiology. Cell physiology 2020 May 1;318(5):C857-C869
Grandmaternal betaine supplementation enhances hepatic IGF2 expression in F2 rat offspring through modification of promoter DNA methylation.
Yang S, Zhao N, Sun B, Yang Y, Hu Y, Zhao R
Journal of the science of food and agriculture 2020 Mar 15;100(4):1486-1494
Journal of the science of food and agriculture 2020 Mar 15;100(4):1486-1494
Dietary betaine improves egg-laying rate in hens through hypomethylation and glucocorticoid receptor-mediated activation of hepatic lipogenesis-related genes.
Omer NA, Hu Y, Idriss AA, Abobaker H, Hou Z, Yang S, Ma W, Zhao R
Poultry science 2020 Jun;99(6):3121-3132
Poultry science 2020 Jun;99(6):3121-3132
Maternal betaine supplementation decreases hepatic cholesterol deposition in chicken offspring with epigenetic modulation of SREBP2 and CYP7A1 genes.
Hu Y, Feng Y, Ding Z, Lv L, Sui Y, Sun Q, Abobaker H, Cai D, Zhao R
Poultry science 2020 Jun;99(6):3111-3120
Poultry science 2020 Jun;99(6):3111-3120
Radiation-Induced DNMT3B Promotes Radioresistance in Nasopharyngeal Carcinoma through Methylation of p53 and p21.
Wu C, Guo E, Ming J, Sun W, Nie X, Sun L, Peng S, Luo M, Liu D, Zhang L, Mei Q, Long G, Hu G, Hu G
Molecular therapy oncolytics 2020 Jun 26;17:306-319
Molecular therapy oncolytics 2020 Jun 26;17:306-319
Nanosecond pulsed electric fields enhance mesenchymal stem cells differentiation via DNMT1-regulated OCT4/NANOG gene expression.
Li K, Ning T, Wang H, Jiang Y, Zhang J, Ge Z
Stem cell research & therapy 2020 Jul 22;11(1):308
Stem cell research & therapy 2020 Jul 22;11(1):308
Transgenerational Inheritance of Betaine-Induced Epigenetic Alterations in Estrogen-Responsive IGF-2/IGFBP2 Genes in Rat Hippocampus.
Yang Y, Jiang W, Yang S, Qi F, Zhao R
Molecular nutrition & food research 2020 Apr;64(8):e1900823
Molecular nutrition & food research 2020 Apr;64(8):e1900823
ACADS acts as a potential methylation biomarker associated with the proliferation and metastasis of hepatocellular carcinomas.
Chen D, Feng X, Lv Z, Xu X, Lu Y, Wu W, Wu H, Liu H, Cao L, Ye S, Chen J, Wu J
Aging 2019 Oct 25;11(20):8825-8844
Aging 2019 Oct 25;11(20):8825-8844
LncRNA NKILA regulates endothelium inflammation by controlling a NF-κB/KLF4 positive feedback loop.
Zhu X, Du J, Yu J, Guo R, Feng Y, Qiao L, Xu Z, Yang F, Zhong G, Liu F, Cheng F, Chu M, Lin J
Journal of molecular and cellular cardiology 2019 Jan;126:60-69
Journal of molecular and cellular cardiology 2019 Jan;126:60-69
Homocysteine impairs porcine oocyte quality via deregulation of one-carbon metabolism and hypermethylation of mitochondrial DNA†.
Jia L, Zeng Y, Hu Y, Liu J, Yin C, Niu Y, Wang C, Li J, Jia Y, Hong J, Zhao R
Biology of reproduction 2019 Apr 1;100(4):907-916
Biology of reproduction 2019 Apr 1;100(4):907-916
Dietary betaine activates hepatic VTGII expression in laying hens associated with hypomethylation of GR gene promoter and enhanced GR expression.
Omer NA, Hu Y, Hu Y, Idriss AA, Abobaker H, Hou Z, Dong H, Zhao R
Journal of animal science and biotechnology 2018;9:2
Journal of animal science and biotechnology 2018;9:2
Dietary betaine supplementation in hens modulates hypothalamic expression of cholesterol metabolic genes in F1 cockerels through modification of DNA methylation.
Idriss AA, Hu Y, Hou Z, Hu Y, Sun Q, Omer NA, Abobaker H, Ni Y, Zhao R
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2018 Mar;217:14-20
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2018 Mar;217:14-20
Phosphatidylinositol 3-Kinase-DNA Methyltransferase 1-miR-1281-Histone Deacetylase 4 Regulatory Axis Mediates Platelet-Derived Growth Factor-Induced Proliferation and Migration of Pulmonary Artery Smooth Muscle Cells.
Li Y, Li L, Qian Z, Lin B, Chen J, Luo Y, Qu J, Raj JU, Gou D
Journal of the American Heart Association 2018 Mar 7;7(6)
Journal of the American Heart Association 2018 Mar 7;7(6)
Mitotically Stable Modification of DNA Methylation in IGF2/H19 Imprinting Control Region Is Associated with Activated Hepatic IGF2 Expression in Offspring Rats from Betaine-Supplemented Dams.
Yang S, Zhao N, Yang Y, Hu Y, Dong H, Zhao R
Journal of agricultural and food chemistry 2018 Mar 21;66(11):2704-2713
Journal of agricultural and food chemistry 2018 Mar 21;66(11):2704-2713
Corticosterone-Induced Lipogenesis Activation and Lipophagy Inhibition in Chicken Liver Are Alleviated by Maternal Betaine Supplementation.
Hu Y, Sun Q, Hu Y, Hou Z, Zong Y, Omer NA, Abobaker H, Zhao R
The Journal of nutrition 2018 Mar 1;148(3):316-325
The Journal of nutrition 2018 Mar 1;148(3):316-325
Mechanism of prolactin inhibition of miR-135b via methylation in goat mammary epithelial cells.
Chen Z, Luo J, Zhang C, Ma Y, Sun S, Zhang T, Loor JJ
Journal of cellular physiology 2018 Jan;233(1):651-662
Journal of cellular physiology 2018 Jan;233(1):651-662
Melatonin-induced increase of lipid droplets accumulation and in vitro maturation in porcine oocytes is mediated by mitochondrial quiescence.
He B, Yin C, Gong Y, Liu J, Guo H, Zhao R
Journal of cellular physiology 2018 Jan;233(1):302-312
Journal of cellular physiology 2018 Jan;233(1):302-312
The inhibition of UBC13 expression and blockage of the DNMT1-CHFR-Aurora A pathway contribute to paclitaxel resistance in ovarian cancer.
Zhang X, Feng Y, Wang XY, Zhang YN, Yuan CN, Zhang SF, Shen YM, Fu YF, Zhou CY, Li X, Cheng XD, Lu WG, Xie X
Cell death & disease 2018 Jan 24;9(2):93
Cell death & disease 2018 Jan 24;9(2):93
In Vivo Ovarian Cancer Gene Therapy Using CRISPR-Cas9.
He ZY, Zhang YG, Yang YH, Ma CC, Wang P, Du W, Li L, Xiang R, Song XR, Zhao X, Yao SH, Wei YQ
Human gene therapy 2018 Feb;29(2):223-233
Human gene therapy 2018 Feb;29(2):223-233
Maternal betaine administration modulates hepatic type 1 iodothyronine deiodinase (Dio1) expression in chicken offspring through epigenetic modifications.
Hou Z, Sun Q, Hu Y, Yang S, Zong Y, Zhao R
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2018 Apr;218:30-36
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2018 Apr;218:30-36
Regulatory Axis of miR-195/497 and HMGA1-Id3 Governs Muscle Cell Proliferation and Differentiation.
Qiu H, Zhong J, Luo L, Tang Z, Liu N, Kang K, Li L, Gou D
International journal of biological sciences 2017;13(2):157-166
International journal of biological sciences 2017;13(2):157-166
Epigenetic modification differences between fetal fibroblast cells and mesenchymal stem cells of the Arbas Cashmere goat.
Wang X, Wang Z, Wang Q, Wang H, Liang H, Liu D
Research in veterinary science 2017 Oct;114:363-369
Research in veterinary science 2017 Oct;114:363-369
Prenatal betaine exposure modulates hypothalamic expression of cholesterol metabolic genes in cockerels through modifications of DNA methylation.
Idriss AA, Hu Y, Sun Q, Jia L, Jia Y, Omer NA, Abobaker H, Zhao R
Poultry science 2017 Jun 1;96(6):1715-1724
Poultry science 2017 Jun 1;96(6):1715-1724
The synthetic antihyperlipidemic drug potassium piperate selectively kills breast cancer cells through inhibiting G1-S-phase transition and inducing apoptosis.
Fan L, Cao X, Yan H, Wang Q, Tian X, Zhang L, He X, Borjihan G, Morigen
Oncotarget 2017 Jul 18;8(29):47250-47268
Oncotarget 2017 Jul 18;8(29):47250-47268
Abnormally activated one-carbon metabolic pathway is associated with mtDNA hypermethylation and mitochondrial malfunction in the oocytes of polycystic gilt ovaries.
Jia L, Li J, He B, Jia Y, Niu Y, Wang C, Zhao R
Scientific reports 2016 Jan 13;6:19436
Scientific reports 2016 Jan 13;6:19436
HIC1 epigenetically represses CIITA transcription in B lymphocytes.
Zeng S, Yang Y, Cheng X, Zhou B, Li P, Zhao Y, Kong X, Xu Y
Biochimica et biophysica acta 2016 Dec;1859(12):1481-1489
Biochimica et biophysica acta 2016 Dec;1859(12):1481-1489
miR-148a-3p represses proliferation and EMT by establishing regulatory circuits between ERBB3/AKT2/c-myc and DNMT1 in bladder cancer.
Wang X, Liang Z, Xu X, Li J, Zhu Y, Meng S, Li S, Wang S, Xie B, Ji A, Liu B, Zheng X, Xie L
Cell death & disease 2016 Dec 1;7(12):e2503
Cell death & disease 2016 Dec 1;7(12):e2503
In Ovo injection of betaine affects hepatic cholesterol metabolism through epigenetic gene regulation in newly hatched chicks.
Hu Y, Sun Q, Li X, Wang M, Cai D, Li X, Zhao R
PloS one 2015;10(4):e0122643
PloS one 2015;10(4):e0122643
Dietary betaine supplementation to gestational sows enhances hippocampal IGF2 expression in newborn piglets with modified DNA methylation of the differentially methylated regions.
Li X, Sun Q, Li X, Cai D, Sui S, Jia Y, Song H, Zhao R
European journal of nutrition 2015 Oct;54(7):1201-10
European journal of nutrition 2015 Oct;54(7):1201-10
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 24206-1-AP( DNMT1 Antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The DNMT1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human DNMT1. This antibody recognizes human antigen. The DNMT1 antibody has been validated for the following applications: ELISA, IP, WB, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-DNMT1 (IP:24206-1-AP, 5ug; Detection:24206-1-AP 1:500) with HEK-293 cells lysate 2500ug.
- Sample type
- cell line