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LearnALX-804-369-C100
antibody from Enzo Life Sciences
Targeting: DNMT1
CXXC9, DNMT, MCMT
Western blot
Immunocytochemistry
Immunoprecipitation Immunohistochemistry Chromatin ImmunoprecipitationAntibody data
- Antibody Data
- Antigen structure
- References [17]
- Comments [0]
- Validations
- Immunocytochemistry [2]
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- Product number
- ALX-804-369-C100 - Provider product page
- Provider
- Enzo Life Sciences
- Proper citation
- Enzo Life Sciences Cat#ALX-804-369-C100, RRID:AB_2051311
- Product name
- Dnmt1 monoclonal antibody (60B1220.1)
- Antibody type
- Monoclonal
- Antigen
- Synthetic peptide
- Description
- Protein G-affinity purified.
- Reactivity
- Human, Mouse, Zebrafish
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- 60B1220.1
- Vial size
- 100 μg
- Storage
- -20°C
- Handling
- Avoid freeze/thaw cycles.
Submitted references 5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signal.
Establishment and characterization of SRIK-NKL: a novel CD8+ natural killer/T cell line derived from a patient with leukemic phase of acute lymphoblastic lymphoma.
Deregulation of DNA methyltransferases and loss of parental methylation at the insulin-like growth factor II (Igf2)/H19 loci in p53 knockout mice prior to tumor development.
An association of DNMT3b protein expression with P16INK4a promoter hypermethylation in non-smoking female lung cancer with human papillomavirus infection.
Immunology of cutaneous vasculitis associated with both etanercept and infliximab.
Induction of DNA methylation and gene silencing by short interfering RNAs in human cells.
Loss of estrogen receptor signaling triggers epigenetic silencing of downstream targets in breast cancer.
RNA interference-mediated knockdown of DNA methyltransferase 1 leads to promoter demethylation and gene re-expression in human lung and breast cancer cells.
Components of a pathway maintaining histone modification and heterochromatin protein 1 binding at the pericentric heterochromatin in Mammalian cells.
Double RNA interference of DNMT3b and DNMT1 enhances DNA demethylation and gene reactivation.
Decrease of DNA methyltransferase 1 expression relative to cell proliferation in transitional cell carcinoma.
Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns.
The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription.
Farnesyltransferase inhibitor (L-744,832) restores TGF-beta type II receptor expression and enhances radiation sensitivity in K-ras mutant pancreatic cancer cell line MIA PaCa-2.
Age-dependent DNA methylation changes in the ITGAL (CD11a) promoter.
The Epstein-Barr virus oncogene product, latent membrane protein 1, induces the downregulation of E-cadherin gene expression via activation of DNA methyltransferases.
Lsh, a member of the SNF2 family, is required for genome-wide methylation.
Ghoshal K, Datta J, Majumder S, Bai S, Kutay H, Motiwala T, Jacob ST
Molecular and cellular biology 2005 Jun;25(11):4727-41
Molecular and cellular biology 2005 Jun;25(11):4727-41
Establishment and characterization of SRIK-NKL: a novel CD8+ natural killer/T cell line derived from a patient with leukemic phase of acute lymphoblastic lymphoma.
Srivastava BI, Srivastava MD
Leukemia research 2005 Jul;29(7):771-83
Leukemia research 2005 Jul;29(7):771-83
Deregulation of DNA methyltransferases and loss of parental methylation at the insulin-like growth factor II (Igf2)/H19 loci in p53 knockout mice prior to tumor development.
Park IY, Sohn BH, Choo JH, Joe CO, Seong JK, Lee YI, Chung JH
Journal of cellular biochemistry 2005 Feb 15;94(3):585-96
Journal of cellular biochemistry 2005 Feb 15;94(3):585-96
An association of DNMT3b protein expression with P16INK4a promoter hypermethylation in non-smoking female lung cancer with human papillomavirus infection.
Lin TS, Lee H, Chen RA, Ho ML, Lin CY, Chen YH, Tsai YY, Chou MC, Cheng YW
Cancer letters 2005 Aug 8;226(1):77-84
Cancer letters 2005 Aug 8;226(1):77-84
Immunology of cutaneous vasculitis associated with both etanercept and infliximab.
Srivastava MD, Alexander F, Tuthill RJ
Scandinavian journal of immunology 2005 Apr;61(4):329-36
Scandinavian journal of immunology 2005 Apr;61(4):329-36
Induction of DNA methylation and gene silencing by short interfering RNAs in human cells.
Kawasaki H, Taira K
Nature 2004 Sep 9;431(7005):211-7
Nature 2004 Sep 9;431(7005):211-7
Loss of estrogen receptor signaling triggers epigenetic silencing of downstream targets in breast cancer.
Leu YW, Yan PS, Fan M, Jin VX, Liu JC, Curran EM, Welshons WV, Wei SH, Davuluri RV, Plass C, Nephew KP, Huang TH
Cancer research 2004 Nov 15;64(22):8184-92
Cancer research 2004 Nov 15;64(22):8184-92
RNA interference-mediated knockdown of DNA methyltransferase 1 leads to promoter demethylation and gene re-expression in human lung and breast cancer cells.
Suzuki M, Sunaga N, Shames DS, Toyooka S, Gazdar AF, Minna JD
Cancer research 2004 May 1;64(9):3137-43
Cancer research 2004 May 1;64(9):3137-43
Components of a pathway maintaining histone modification and heterochromatin protein 1 binding at the pericentric heterochromatin in Mammalian cells.
Xin H, Yoon HG, Singh PB, Wong J, Qin J
The Journal of biological chemistry 2004 Mar 5;279(10):9539-46
The Journal of biological chemistry 2004 Mar 5;279(10):9539-46
Double RNA interference of DNMT3b and DNMT1 enhances DNA demethylation and gene reactivation.
Leu YW, Rahmatpanah F, Shi H, Wei SH, Liu JC, Yan PS, Huang TH
Cancer research 2003 Oct 1;63(19):6110-5
Cancer research 2003 Oct 1;63(19):6110-5
Decrease of DNA methyltransferase 1 expression relative to cell proliferation in transitional cell carcinoma.
Kimura F, Seifert HH, Florl AR, Santourlidis S, Steinhoff C, Swiatkowski S, Mahotka C, Gerharz CD, Schulz WA
International journal of cancer 2003 May 1;104(5):568-78
International journal of cancer 2003 May 1;104(5):568-78
Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns.
Craig JM, Earle E, Canham P, Wong LH, Anderson M, Choo KH
Human molecular genetics 2003 Dec 1;12(23):3109-21
Human molecular genetics 2003 Dec 1;12(23):3109-21
The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription.
Santoro R, Li J, Grummt I
Nature genetics 2002 Nov;32(3):393-6
Nature genetics 2002 Nov;32(3):393-6
Farnesyltransferase inhibitor (L-744,832) restores TGF-beta type II receptor expression and enhances radiation sensitivity in K-ras mutant pancreatic cancer cell line MIA PaCa-2.
Alcock RA, Dey S, Chendil D, Inayat MS, Mohiuddin M, Hartman G, Chatfield LK, Gallicchio VS, Ahmed MM
Oncogene 2002 Nov 7;21(51):7883-90
Oncogene 2002 Nov 7;21(51):7883-90
Age-dependent DNA methylation changes in the ITGAL (CD11a) promoter.
Zhang Z, Deng C, Lu Q, Richardson B
Mechanisms of ageing and development 2002 May;123(9):1257-68
Mechanisms of ageing and development 2002 May;123(9):1257-68
The Epstein-Barr virus oncogene product, latent membrane protein 1, induces the downregulation of E-cadherin gene expression via activation of DNA methyltransferases.
Tsai CN, Tsai CL, Tse KP, Chang HY, Chang YS
Proceedings of the National Academy of Sciences of the United States of America 2002 Jul 23;99(15):10084-9
Proceedings of the National Academy of Sciences of the United States of America 2002 Jul 23;99(15):10084-9
Lsh, a member of the SNF2 family, is required for genome-wide methylation.
Dennis K, Fan T, Geiman T, Yan Q, Muegge K
Genes & development 2001 Nov 15;15(22):2940-4
Genes & development 2001 Nov 15;15(22):2940-4
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Supportive validation
- Submitted by
- Enzo Life Sciences (provider)
- Main image
- Experimental details
- Western blot analysis for Dnmt1 using ALX-804-369 at 2µg/ml dilution against 10µg of cell lysates of mouse ES cell.
- Submitted by
- Enzo Life Sciences (provider)
- Main image
- Experimental details
- Immunohistochemistry of Dnmt1 using ALX-804-369 at 2µg/ml on formalin-fixed paraffin-embedded medullar kidney tissue sections.
