NB100-316

Sato K, Brandsma I, van Rossum-Fikkert SE, Verkaik N, Oostra AB, Dorsman JC, van Gent DC, Knipscheer P, Kanaar R, Zelensky AN
Nucleic acids research 2020 Mar 18;48(5):2442-2456

Base and nucleotide excision repair facilitate resolution of platinum drugs-induced transcription blockage.

Slyskova J, Sabatella M, Ribeiro-Silva C, Stok C, Theil AF, Vermeulen W, Lans H
Nucleic acids research 2018 Oct 12;46(18):9537-9549

Fanconi anemia signaling network regulates the spindle assembly checkpoint.

Nalepa G, Enzor R, Sun Z, Marchal C, Park SJ, Yang Y, Tedeschi L, Kelich S, Hanenberg H, Clapp DW
The Journal of clinical investigation 2013 Sep;123(9):3839-47

The antitumor agent doxorubicin binds to Fanconi anemia group F protein.

Kusayanagi T, Tsukuda S, Shimura S, Manita D, Iwakiri K, Kamisuki S, Takakusagi Y, Takeuchi T, Kuramochi K, Nakazaki A, Sakaguchi K, Kobayashi S, Sugawara F
Bioorganic & medicinal chemistry 2012 Nov 1;20(21):6248-55

Fanconi anemia D2 protein is an apoptotic target mediated by caspases.

Park SJ, Beck BD, Saadatzadeh MR, Haneline LS, Clapp DW, Lee SH
Journal of cellular biochemistry 2011 Sep;112(9):2383-91

Involvement of p29 in DNA damage responses and Fanconi anemia pathway.

Chu PC, Wang TY, Lu YT, Chou CK, Yang YC, Chang MS
Carcinogenesis 2009 Oct;30(10):1710-6

XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair.

Bhagwat N, Olsen AL, Wang AT, Hanada K, Stuckert P, Kanaar R, D'Andrea A, Niedernhofer LJ, McHugh PJ
Molecular and cellular biology 2009 Dec;29(24):6427-37

Utility of DNA repair protein foci for the detection of putative BRCA1 pathway defects in breast cancer biopsies.

Willers H, Taghian AG, Luo CM, Treszezamsky A, Sgroi DC, Powell SN
Molecular cancer research : MCR 2009 Aug;7(8):1304-9

HES1 is a novel interactor of the Fanconi anemia core complex.

Tremblay CS, Huang FF, Habi O, Huard CC, Godin C, Lévesque G, Carreau M
Blood 2008 Sep 1;112(5):2062-70

Overnight transduction with foamyviral vectors restores the long-term repopulating activity of Fancc-/- stem cells.

Si Y, Pulliam AC, Linka Y, Ciccone S, Leurs C, Yuan J, Eckermann O, Fruehauf S, Mooney S, Hanenberg H, Clapp DW
Blood 2008 Dec 1;112(12):4458-65

Human Mus81 and FANCB independently contribute to repair of DNA damage during replication.

Nomura Y, Adachi N, Koyama H
Genes to cells : devoted to molecular & cellular mechanisms 2007 Oct;12(10):1111-22

Oxidative stress/damage induces multimerization and interaction of Fanconi anemia proteins.

Park SJ, Ciccone SL, Beck BD, Hwang B, Freie B, Clapp DW, Lee SH
The Journal of biological chemistry 2004 Jul 16;279(29):30053-9

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Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Simple Western: FANCD2 Antibody (FI-17) [NB100-316] - Image shows a specific band for FANCD2 in 1 mg/mL of HeLa cell lysate using FANCD2 Antibody (FI-17). This experiment was performed under reducing conditions using the 12-230 kDa separation system.

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Western Blot: FANCD2 Antibody (FI-17) [NB100-316] - Expression of FANCD2 (Molecular weight: 164.1 KDa) in different cell lines. Proliferating cells were treated with 10-Gy IR. 50 ug protein was loaded each lane. FANCD2 Antibody (FI-17) at 1:1000.

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Western Blot: FANCD2 Antibody (FI-17) [NB100-316] - MCF7 cell line (lane 1, molecular weight: 164.1 KDa) and HeLa whole cell extract (lane 2) using FANCD2 Antibody (FI-17).