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- Antibody Data
- Antigen structure
- References [131]
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- Western blot [2]
- Immunocytochemistry [3]
- Immunohistochemistry [1]
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- Product number
- ABIN151329 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Fanconi Anemia, Complementation Group D2 (FANCD2) (N-Term) antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified
- Reactivity
- Human, Mouse, Canine, Simian
- Host
- Rabbit
- Epitope
- N-Term
- Vial size
- 0.05 mL
- Storage
- Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
- Handling
- Avoid freeze-thaw cycles
Submitted references New insights into diagnosis and therapeutic options for proliferative hepatoblastoma.
Somatic mosaicism of an intragenic FANCB duplication in both fibroblast and peripheral blood cells observed in a Fanconi anemia patient leads to milder phenotype.
Modulation of the Fanconi anemia pathway via chemically induced changes in chromatin structure.
A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival.
BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination.
BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity.
Aquarius is required for proper CtIP expression and homologous recombination repair.
FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2.
Tuning the Multifunctionality of Iron Oxide Nanoparticles Using Self-Assembled Mixed Lipid Layers.
Arsenite Binds to the RING Finger Domain of FANCL E3 Ubiquitin Ligase and Inhibits DNA Interstrand Crosslink Repair.
ILF2 Is a Regulator of RNA Splicing and DNA Damage Response in 1q21-Amplified Multiple Myeloma.
Fanconi anemia protein FANCD2 is activated by AICAR, a modulator of AMPK and cellular energy metabolism.
S. pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity.
FANCD2 Binds Human Papillomavirus Genomes and Associates with a Distinct Set of DNA Repair Proteins to Regulate Viral Replication.
Fanconi anemia FANCD2 and FANCI proteins regulate the nuclear dynamics of splicing factors.
RECQ-like helicases Sgs1 and BLM regulate R-loop-associated genome instability.
The identification of FANCD2 DNA binding domains reveals nuclear localization sequences.
Generation of an induced pluripotent stem cell line that mimics the disease phenotypes from a patient with Fanconi anemia by conditional complementation.
Dearth and Delayed Maturation of Testicular Germ Cells in Fanconi Anemia E Mutant Male Mice.
Intrinsic Radiosensitivity and Cellular Characterization of 27 Canine Cancer Cell Lines.
Cell resistance to the Cytolethal Distending Toxin involves an association of DNA repair mechanisms.
Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications.
The PTEN phosphatase functions cooperatively with the Fanconi anemia proteins in DNA crosslink repair.
Leukemic survival factor SALL4 contributes to defective DNA damage repair.
BLM promotes the activation of Fanconi Anemia signaling pathway.
FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair.
Aurora A kinase is required for activation of the Fanconi anemia/BRCA pathway upon DNA damage.
FANCI-FANCD2 stabilizes the RAD51-DNA complex by binding RAD51 and protects the 5'-DNA end.
FANCD2 limits replication stress and genome instability in cells lacking BRCA2.
FANCD2 limits BLM-dependent telomere instability in the alternative lengthening of telomeres pathway.
FANCD2 influences replication fork processes and genome stability in response to clustered DSBs.
Analysis of a FANCE Splice Isoform in Regard to DNA Repair.
Defects in the Fanconi Anemia Pathway and Chromatid Cohesion in Head and Neck Cancer.
K63-linked ubiquitination of FANCG is required for its association with the Rap80-BRCA1 complex to modulate homologous recombination repair of DNA interstand crosslinks.
Ubiquitin-like protein UBL5 promotes the functional integrity of the Fanconi anemia pathway.
Loss of Faap20 Causes Hematopoietic Stem and Progenitor Cell Depletion in Mice Under Genotoxic Stress.
Deficiency of UBE2T, the E2 Ubiquitin Ligase Necessary for FANCD2 and FANCI Ubiquitination, Causes FA-T Subtype of Fanconi Anemia.
Proteome-wide analysis of SUMO2 targets in response to pathological DNA replication stress in human cells.
DNA helicases FANCM and DDX11 are determinants of PARP inhibitor sensitivity.
Replication stress activates DNA repair synthesis in mitosis.
UVA photoactivation of DNA containing halogenated thiopyrimidines induces cytotoxic DNA lesions.
Functional Genetic Screen Identifies Increased Sensitivity to WEE1 Inhibition in Cells with Defects in Fanconi Anemia and HR Pathways.
RNF4-mediated polyubiquitination regulates the Fanconi anemia/BRCA pathway.
Fanconi anemia repair pathway dysfunction, a potential therapeutic target in lung cancer.
High-risk human papillomavirus E6 protein promotes reprogramming of Fanconi anemia patient cells through repression of p53 but does not allow for sustained growth of induced pluripotent stem cells.
Roles of SLX1-SLX4, MUS81-EME1, and GEN1 in avoiding genome instability and mitotic catastrophe.
Basal level of FANCD2 monoubiquitination is required for the maintenance of a sufficient number of licensed-replication origins to fire at a normal rate.
Modularized functions of the Fanconi anemia core complex.
The Fanconi anemia pathway has a dual function in Dickkopf-1 transcriptional repression.
DNA damage to a single chromosome end delays anaphase onset.
Coordinate nuclear targeting of the FANCD2 and FANCI proteins via a FANCD2 nuclear localization signal.
Ouabain, a cardiac glycoside, inhibits the Fanconi anemia/BRCA pathway activated by DNA interstrand cross-linking agents.
Architecture and DNA recognition elements of the Fanconi anemia FANCM-FAAP24 complex.
Structure analysis of FAAP24 reveals single-stranded DNA-binding activity and domain functions in DNA damage response.
EGFR-activating mutations correlate with a Fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity.
Anthracyclines induce DNA damage response-mediated protection against severe sepsis.
Reduced FANCD2 influences spontaneous SCE and RAD51 foci formation in uveal melanoma and Fanconi anaemia.
Non-erythroid alpha spectrin prevents telomere dysfunction after DNA interstrand cross-link damage.
Assessment of FANCD2 nuclear foci formation in paraffin-embedded tumors: a potential patient-enrichment strategy for treatment with DNA interstrand crosslinking agents.
FANCM and FAAP24 maintain genome stability via cooperative as well as unique functions.
Recruitment of DNA polymerase eta by FANCD2 in the early response to DNA damage.
Senataxin, defective in the neurodegenerative disorder ataxia with oculomotor apraxia 2, lies at the interface of transcription and the DNA damage response.
Regulation of multiple DNA repair pathways by the Fanconi anemia protein SLX4.
Multifunctionality of the FA pathway.
Rev3, the catalytic subunit of Polζ, is required for maintaining fragile site stability in human cells.
The SNM1B/APOLLO DNA nuclease functions in resolution of replication stress and maintenance of common fragile site stability.
A novel interplay between the Fanconi anemia core complex and ATR-ATRIP kinase during DNA cross-link repair.
MUS81 promotes common fragile site expression.
CtIP is required to initiate replication-dependent interstrand crosslink repair.
Identification of the first ATRIP-deficient patient and novel mutations in ATR define a clinical spectrum for ATR-ATRIP Seckel Syndrome.
UBR2 of the N-end rule pathway is required for chromosome stability via histone ubiquitylation in spermatocytes and somatic cells.
Regulation of the Fanconi anemia pathway by a CUE ubiquitin-binding domain in the FANCD2 protein.
Oxidation-mediated DNA cross-linking contributes to the toxicity of 6-thioguanine in human cells.
Processing of anthracycline-DNA adducts via DNA replication and interstrand crosslink repair pathways.
Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair.
FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair.
Bone marrow failure in Fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells.
Regulation of the activation of the Fanconi anemia pathway by the p21 cyclin-dependent kinase inhibitor.
Dysregulation of DNA polymerase κ recruitment to replication forks results in genomic instability.
The fanconi anemia pathway limits human papillomavirus replication.
MiR-96 downregulates REV1 and RAD51 to promote cellular sensitivity to cisplatin and PARP inhibition.
FAVL impairment of the Fanconi anemia pathway promotes the development of human bladder cancer.
Non-specific chemical inhibition of the Fanconi anemia pathway sensitizes cancer cells to cisplatin.
Long range regulation of human FXN gene expression.
Lac operator repeats generate a traceable fragile site in mammalian cells.
The human DEK oncogene regulates DNA damage response signaling and repair.
The Fanconi anemia pathway is downregulated upon macrophage differentiation through two distinct mechanisms.
Differential roles for Chk1 and FANCD2 in ATR-mediated signalling for psoralen photoactivation-induced senescence.
Ovarian surface epitheliectomy in the non-human primate: continued cyclic ovarian function and limited epithelial replacement.
Snm1B/Apollo functions in the Fanconi anemia pathway in response to DNA interstrand crosslinks.
Spontaneous abrogation of the G₂DNA damage checkpoint has clinical benefits but promotes leukemogenesis in Fanconi anemia patients.
Mutations of the SLX4 gene in Fanconi anemia.
SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype.
Patient-derived C-terminal mutation of FANCI causes protein mislocalization and reveals putative EDGE motif function in DNA repair.
The cytomegaloviral protein pUL138 acts as potentiator of tumor necrosis factor (TNF) receptor 1 surface density to enhance ULb'-encoded modulation of TNF-α signaling.
Efficient DNA interstrand crosslinking by 6-thioguanine and UVA radiation.
HP1alpha recruitment to DNA damage by p150CAF-1 promotes homologous recombination repair.
A first genome assembly of the barley fungal pathogen Pyrenophora teres f. teres.
Recycling cohesin rings by deacetylation.
Multicellular development in a choanoflagellate.
Control of bacterial iron homeostasis by manganese.
A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.
Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2.
Constitutive activation of caspase-3 and Poly ADP ribose polymerase cleavage in fanconi anemia cells.
Functional interaction between the Fanconi Anemia D2 protein and proliferating cell nuclear antigen (PCNA) via a conserved putative PCNA interaction motif.
Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells.
XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair.
FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia.
Biomarkers and mechanisms of FANCD2 function.
HES1 is a novel interactor of the Fanconi anemia core complex.
Hsp90 regulates the Fanconi anemia DNA damage response pathway.
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase.
Proteasome function is required for DNA damage response and fanconi anemia pathway activation.
HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability.
Young patients with oral squamous cell carcinoma: study of the involvement of GSTP1 and deregulation of the Fanconi anemia genes.
Defective mitochondrial peroxiredoxin-3 results in sensitivity to oxidative stress in Fanconi anemia.
Activation of the Fanconi anemia/BRCA pathway and recombination repair in the cellular response to solar ultraviolet light.
Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks.
Nbs1 is required for ATR-dependent phosphorylation events.
A Rad50-dependent pathway of DNA repair is deficient in Fanconi anemia fibroblasts.
Human SNM1B is required for normal cellular response to both DNA interstrand crosslink-inducing agents and ionizing radiation.
Repair kinetics of genomic interstrand DNA cross-links: evidence for DNA double-strand break-dependent activation of the Fanconi anemia/BRCA pathway.
Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors.
FANCF methylation contributes to chemoselectivity in ovarian cancer.
Nonerythroid alphaII spectrin is required for recruitment of FANCA and XPF to nuclear foci induced by DNA interstrand cross-links.
Acquired FANCA dysfunction and cytogenetic instability in adult acute myelogenous leukemia.
S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51.
Attenuation of the formation of DNA-repair foci containing RAD51 in Fanconi anaemia.
Human alpha spectrin II and the FANCA, FANCC, and FANCG proteins bind to DNA containing psoralen interstrand cross-links.
Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway.
Targeted disruption of the murine Fanconi anemia gene, Fancg/Xrcc9.
Hooks KB, Audoux J, Fazli H, Lesjean S, Ernault T, Dugot-Senant N, Leste-Lasserre T, Hagedorn M, Rousseau B, Danet C, Branchereau S, Brugières L, Taque S, Guettier C, Fabre M, Rullier A, Buendia MA, Commes T, Grosset CF, Raymond AA
Hepatology (Baltimore, Md.) 2018 Jul;68(1):89-102
Hepatology (Baltimore, Md.) 2018 Jul;68(1):89-102
Somatic mosaicism of an intragenic FANCB duplication in both fibroblast and peripheral blood cells observed in a Fanconi anemia patient leads to milder phenotype.
Asur RS, Kimble DC, Lach FP, Jung M, Donovan FX, Kamat A, Noonan RJ, Thomas JW, Park M, Chines P, Vlachos A, Auerbach AD, Smogorzewska A, Chandrasekharappa SC
Molecular genetics & genomic medicine 2018 Jan;6(1):77-91
Molecular genetics & genomic medicine 2018 Jan;6(1):77-91
Modulation of the Fanconi anemia pathway via chemically induced changes in chromatin structure.
Vierra DA, Garzon JL, Rego MA, Adroved MM, Mauro M, Howlett NG
Oncotarget 2017 Sep 29;8(44):76443-76457
Oncotarget 2017 Sep 29;8(44):76443-76457
A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival.
Bou Samra E, Buhagiar-Labarchède G, Machon C, Guitton J, Onclercq-Delic R, Green MR, Alibert O, Gazin C, Veaute X, Amor-Guéret M
Nature communications 2017 Sep 25;8(1):693
Nature communications 2017 Sep 25;8(1):693
BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination.
Feng W, Jasin M
Nature communications 2017 Sep 13;8(1):525
Nature communications 2017 Sep 13;8(1):525
BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity.
Tacconi EM, Lai X, Folio C, Porru M, Zonderland G, Badie S, Michl J, Sechi I, Rogier M, Matía García V, Batra AS, Rueda OM, Bouwman P, Jonkers J, Ryan A, Reina-San-Martin B, Hui J, Tang N, Bruna A, Biroccio A, Tarsounas M
EMBO molecular medicine 2017 Oct;9(10):1398-1414
EMBO molecular medicine 2017 Oct;9(10):1398-1414
Aquarius is required for proper CtIP expression and homologous recombination repair.
Sakasai R, Isono M, Wakasugi M, Hashimoto M, Sunatani Y, Matsui T, Shibata A, Matsunaga T, Iwabuchi K
Scientific reports 2017 Oct 23;7(1):13808
Scientific reports 2017 Oct 23;7(1):13808
FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2.
Porro A, Berti M, Pizzolato J, Bologna S, Kaden S, Saxer A, Ma Y, Nagasawa K, Sartori AA, Jiricny J
Nature communications 2017 Oct 20;8(1):1073
Nature communications 2017 Oct 20;8(1):1073
Tuning the Multifunctionality of Iron Oxide Nanoparticles Using Self-Assembled Mixed Lipid Layers.
Preiss MR, Cournoyer E, Paquin KL, Vuono EA, Belanger K, Walsh E, Howlett NG, Bothun GD
Bioconjugate chemistry 2017 Nov 15;28(11):2729-2736
Bioconjugate chemistry 2017 Nov 15;28(11):2729-2736
Arsenite Binds to the RING Finger Domain of FANCL E3 Ubiquitin Ligase and Inhibits DNA Interstrand Crosslink Repair.
Jiang J, Bellani M, Li L, Wang P, Seidman MM, Wang Y
ACS chemical biology 2017 Jul 21;12(7):1858-1866
ACS chemical biology 2017 Jul 21;12(7):1858-1866
ILF2 Is a Regulator of RNA Splicing and DNA Damage Response in 1q21-Amplified Multiple Myeloma.
Marchesini M, Ogoti Y, Fiorini E, Aktas Samur A, Nezi L, D'Anca M, Storti P, Samur MK, Ganan-Gomez I, Fulciniti MT, Mistry N, Jiang S, Bao N, Marchica V, Neri A, Bueso-Ramos C, Wu CJ, Zhang L, Liang H, Peng X, Giuliani N, Draetta G, Clise-Dwyer K, Kantarjian H, Munshi N, Orlowski R, Garcia-Manero G, DePinho RA, Colla S
Cancer cell 2017 Jul 10;32(1):88-100.e6
Cancer cell 2017 Jul 10;32(1):88-100.e6
Fanconi anemia protein FANCD2 is activated by AICAR, a modulator of AMPK and cellular energy metabolism.
Chun MJ, Choi H, Jun DW, Kim S, Kim YN, Kim SY, Lee CH
FEBS open bio 2017 Feb;7(2):284-292
FEBS open bio 2017 Feb;7(2):284-292
S. pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity.
Lv Z, Rickman KA, Yuan L, Williams K, Selvam SP, Woosley AN, Howe PH, Ogretmen B, Smogorzewska A, Olsen SK
Molecular cell 2017 Feb 16;65(4):699-714.e6
Molecular cell 2017 Feb 16;65(4):699-714.e6
FANCD2 Binds Human Papillomavirus Genomes and Associates with a Distinct Set of DNA Repair Proteins to Regulate Viral Replication.
Spriggs CC, Laimins LA
mBio 2017 Feb 14;8(1)
mBio 2017 Feb 14;8(1)
Fanconi anemia FANCD2 and FANCI proteins regulate the nuclear dynamics of splicing factors.
Moriel-Carretero M, Ovejero S, Gérus-Durand M, Vryzas D, Constantinou A
The Journal of cell biology 2017 Dec 4;216(12):4007-4026
The Journal of cell biology 2017 Dec 4;216(12):4007-4026
RECQ-like helicases Sgs1 and BLM regulate R-loop-associated genome instability.
Chang EY, Novoa CA, Aristizabal MJ, Coulombe Y, Segovia R, Chaturvedi R, Shen Y, Keong C, Tam AS, Jones SJM, Masson JY, Kobor MS, Stirling PC
The Journal of cell biology 2017 Dec 4;216(12):3991-4005
The Journal of cell biology 2017 Dec 4;216(12):3991-4005
The identification of FANCD2 DNA binding domains reveals nuclear localization sequences.
Niraj J, Caron MC, Drapeau K, Bérubé S, Guitton-Sert L, Coulombe Y, Couturier AM, Masson JY
Nucleic acids research 2017 Aug 21;45(14):8341-8357
Nucleic acids research 2017 Aug 21;45(14):8341-8357
Generation of an induced pluripotent stem cell line that mimics the disease phenotypes from a patient with Fanconi anemia by conditional complementation.
Bharathan SP, Nandy K, Palani D, Janet A NB, Natarajan K, George B, Srivastava A, Velayudhan SR
Stem cell research 2017 Apr;20:54-57
Stem cell research 2017 Apr;20:54-57
Dearth and Delayed Maturation of Testicular Germ Cells in Fanconi Anemia E Mutant Male Mice.
Fu C, Begum K, Jordan PW, He Y, Overbeek PA
PloS one 2016;11(8):e0159800
PloS one 2016;11(8):e0159800
Intrinsic Radiosensitivity and Cellular Characterization of 27 Canine Cancer Cell Lines.
Maeda J, Froning CE, Brents CA, Rose BJ, Thamm DH, Kato TA
PloS one 2016;11(6):e0156689
PloS one 2016;11(6):e0156689
Cell resistance to the Cytolethal Distending Toxin involves an association of DNA repair mechanisms.
Bezine E, Malaisé Y, Loeuillet A, Chevalier M, Boutet-Robinet E, Salles B, Mirey G, Vignard J
Scientific reports 2016 Oct 24;6:36022
Scientific reports 2016 Oct 24;6:36022
Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications.
Alavattam KG, Kato Y, Sin HS, Maezawa S, Kowalski IJ, Zhang F, Pang Q, Andreassen PR, Namekawa SH
Cell reports 2016 Oct 18;17(4):1141-1157
Cell reports 2016 Oct 18;17(4):1141-1157
The PTEN phosphatase functions cooperatively with the Fanconi anemia proteins in DNA crosslink repair.
Vuono EA, Mukherjee A, Vierra DA, Adroved MM, Hodson C, Deans AJ, Howlett NG
Scientific reports 2016 Nov 7;6:36439
Scientific reports 2016 Nov 7;6:36439
Leukemic survival factor SALL4 contributes to defective DNA damage repair.
Wang F, Gao C, Lu J, Tatetsu H, Williams DA, Müller LU, Cui W, Chai L
Oncogene 2016 Nov 24;35(47):6087-6095
Oncogene 2016 Nov 24;35(47):6087-6095
BLM promotes the activation of Fanconi Anemia signaling pathway.
Panneerselvam J, Wang H, Zhang J, Che R, Yu H, Fei P
Oncotarget 2016 May 31;7(22):32351-61
Oncotarget 2016 May 31;7(22):32351-61
FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair.
Kais Z, Rondinelli B, Holmes A, O'Leary C, Kozono D, D'Andrea AD, Ceccaldi R
Cell reports 2016 Jun 14;15(11):2488-99
Cell reports 2016 Jun 14;15(11):2488-99
Aurora A kinase is required for activation of the Fanconi anemia/BRCA pathway upon DNA damage.
Chun MJ, Hwang SK, Kim HG, Goh SH, Kim S, Lee CH
FEBS open bio 2016 Jul;6(7):782-90
FEBS open bio 2016 Jul;6(7):782-90
FANCI-FANCD2 stabilizes the RAD51-DNA complex by binding RAD51 and protects the 5'-DNA end.
Sato K, Shimomuki M, Katsuki Y, Takahashi D, Kobayashi W, Ishiai M, Miyoshi H, Takata M, Kurumizaka H
Nucleic acids research 2016 Dec 15;44(22):10758-10771
Nucleic acids research 2016 Dec 15;44(22):10758-10771
FANCD2 limits replication stress and genome instability in cells lacking BRCA2.
Michl J, Zimmer J, Buffa FM, McDermott U, Tarsounas M
Nature structural & molecular biology 2016 Aug;23(8):755-757
Nature structural & molecular biology 2016 Aug;23(8):755-757
FANCD2 limits BLM-dependent telomere instability in the alternative lengthening of telomeres pathway.
Root H, Larsen A, Komosa M, Al-Azri F, Li R, Bazett-Jones DP, Stephen Meyn M
Human molecular genetics 2016 Aug 1;25(15):3255-3268
Human molecular genetics 2016 Aug 1;25(15):3255-3268
FANCD2 influences replication fork processes and genome stability in response to clustered DSBs.
Zhu J, Su F, Mukherjee S, Mori E, Hu B, Asaithamby A
Cell cycle (Georgetown, Tex.) 2015;14(12):1809-22
Cell cycle (Georgetown, Tex.) 2015;14(12):1809-22
Analysis of a FANCE Splice Isoform in Regard to DNA Repair.
Bouffard F, Plourde K, Bélanger S, Ouellette G, Labrie Y, Durocher F
Journal of molecular biology 2015 Sep 25;427(19):3056-73
Journal of molecular biology 2015 Sep 25;427(19):3056-73
Defects in the Fanconi Anemia Pathway and Chromatid Cohesion in Head and Neck Cancer.
Stoepker C, Ameziane N, van der Lelij P, Kooi IE, Oostra AB, Rooimans MA, van Mil SE, Brink A, Dietrich R, Balk JA, Ylstra B, Joenje H, Feller SM, Brakenhoff RH
Cancer research 2015 Sep 1;75(17):3543-53
Cancer research 2015 Sep 1;75(17):3543-53
K63-linked ubiquitination of FANCG is required for its association with the Rap80-BRCA1 complex to modulate homologous recombination repair of DNA interstand crosslinks.
Zhu B, Yan K, Li L, Lin M, Zhang S, He Q, Zheng D, Yang H, Shao G
Oncogene 2015 May 28;34(22):2867-78
Oncogene 2015 May 28;34(22):2867-78
Ubiquitin-like protein UBL5 promotes the functional integrity of the Fanconi anemia pathway.
Oka Y, Bekker-Jensen S, Mailand N
The EMBO journal 2015 May 12;34(10):1385-98
The EMBO journal 2015 May 12;34(10):1385-98
Loss of Faap20 Causes Hematopoietic Stem and Progenitor Cell Depletion in Mice Under Genotoxic Stress.
Zhang T, Wilson AF, Mahmood Ali A, Namekawa SH, Andreassen PR, Ruhikanta Meetei A, Pang Q
Stem cells (Dayton, Ohio) 2015 Jul;33(7):2320-30
Stem cells (Dayton, Ohio) 2015 Jul;33(7):2320-30
Deficiency of UBE2T, the E2 Ubiquitin Ligase Necessary for FANCD2 and FANCI Ubiquitination, Causes FA-T Subtype of Fanconi Anemia.
Rickman KA, Lach FP, Abhyankar A, Donovan FX, Sanborn EM, Kennedy JA, Sougnez C, Gabriel SB, Elemento O, Chandrasekharappa SC, Schindler D, Auerbach AD, Smogorzewska A
Cell reports 2015 Jul 7;12(1):35-41
Cell reports 2015 Jul 7;12(1):35-41
Proteome-wide analysis of SUMO2 targets in response to pathological DNA replication stress in human cells.
Bursomanno S, Beli P, Khan AM, Minocherhomji S, Wagner SA, Bekker-Jensen S, Mailand N, Choudhary C, Hickson ID, Liu Y
DNA repair 2015 Jan;25:84-96
DNA repair 2015 Jan;25:84-96
DNA helicases FANCM and DDX11 are determinants of PARP inhibitor sensitivity.
Stoepker C, Faramarz A, Rooimans MA, van Mil SE, Balk JA, Velleuer E, Ameziane N, Te Riele H, de Winter JP
DNA repair 2015 Feb;26:54-64
DNA repair 2015 Feb;26:54-64
Replication stress activates DNA repair synthesis in mitosis.
Minocherhomji S, Ying S, Bjerregaard VA, Bursomanno S, Aleliunaite A, Wu W, Mankouri HW, Shen H, Liu Y, Hickson ID
Nature 2015 Dec 10;528(7581):286-90
Nature 2015 Dec 10;528(7581):286-90
UVA photoactivation of DNA containing halogenated thiopyrimidines induces cytotoxic DNA lesions.
Brem R, Zhang X, Xu YZ, Karran P
Journal of photochemistry and photobiology. B, Biology 2015 Apr;145:1-10
Journal of photochemistry and photobiology. B, Biology 2015 Apr;145:1-10
Functional Genetic Screen Identifies Increased Sensitivity to WEE1 Inhibition in Cells with Defects in Fanconi Anemia and HR Pathways.
Aarts M, Bajrami I, Herrera-Abreu MT, Elliott R, Brough R, Ashworth A, Lord CJ, Turner NC
Molecular cancer therapeutics 2015 Apr;14(4):865-76
Molecular cancer therapeutics 2015 Apr;14(4):865-76
RNF4-mediated polyubiquitination regulates the Fanconi anemia/BRCA pathway.
Xie J, Kim H, Moreau LA, Puhalla S, Garber J, Al Abo M, Takeda S, D'Andrea AD
The Journal of clinical investigation 2015 Apr;125(4):1523-32
The Journal of clinical investigation 2015 Apr;125(4):1523-32
Fanconi anemia repair pathway dysfunction, a potential therapeutic target in lung cancer.
Duan W, Gao L, Aguila B, Kalvala A, Otterson GA, Villalona-Calero MA
Frontiers in oncology 2014;4:368
Frontiers in oncology 2014;4:368
High-risk human papillomavirus E6 protein promotes reprogramming of Fanconi anemia patient cells through repression of p53 but does not allow for sustained growth of induced pluripotent stem cells.
Chlon TM, Hoskins EE, Mayhew CN, Wikenheiser-Brokamp KA, Davies SM, Mehta P, Myers KC, Wells JM, Wells SI
Journal of virology 2014 Oct;88(19):11315-26
Journal of virology 2014 Oct;88(19):11315-26
Roles of SLX1-SLX4, MUS81-EME1, and GEN1 in avoiding genome instability and mitotic catastrophe.
Sarbajna S, Davies D, West SC
Genes & development 2014 May 15;28(10):1124-36
Genes & development 2014 May 15;28(10):1124-36
Basal level of FANCD2 monoubiquitination is required for the maintenance of a sufficient number of licensed-replication origins to fire at a normal rate.
Panneerselvam J, Pickering A, Han B, Li L, Zheng J, Zhang J, Zhang Y, Fei P
Oncotarget 2014 Mar 15;5(5):1326-37
Oncotarget 2014 Mar 15;5(5):1326-37
Modularized functions of the Fanconi anemia core complex.
Huang Y, Leung JW, Lowery M, Matsushita N, Wang Y, Shen X, Huong D, Takata M, Chen J, Li L
Cell reports 2014 Jun 26;7(6):1849-57
Cell reports 2014 Jun 26;7(6):1849-57
The Fanconi anemia pathway has a dual function in Dickkopf-1 transcriptional repression.
Huard CC, Tremblay CS, Magron A, Lévesque G, Carreau M
Proceedings of the National Academy of Sciences of the United States of America 2014 Feb 11;111(6):2152-7
Proceedings of the National Academy of Sciences of the United States of America 2014 Feb 11;111(6):2152-7
DNA damage to a single chromosome end delays anaphase onset.
Silva BA, Stambaugh JR, Yokomori K, Shah JV, Berns MW
The Journal of biological chemistry 2014 Aug 15;289(33):22771-84
The Journal of biological chemistry 2014 Aug 15;289(33):22771-84
Coordinate nuclear targeting of the FANCD2 and FANCI proteins via a FANCD2 nuclear localization signal.
Boisvert RA, Rego MA, Azzinaro PA, Mauro M, Howlett NG
PloS one 2013;8(11):e81387
PloS one 2013;8(11):e81387
Ouabain, a cardiac glycoside, inhibits the Fanconi anemia/BRCA pathway activated by DNA interstrand cross-linking agents.
Jun DW, Hwang M, Kim HJ, Hwang SK, Kim S, Lee CH
PloS one 2013;8(10):e75905
PloS one 2013;8(10):e75905
Architecture and DNA recognition elements of the Fanconi anemia FANCM-FAAP24 complex.
Coulthard R, Deans AJ, Swuec P, Bowles M, Costa A, West SC, McDonald NQ
Structure (London, England : 1993) 2013 Sep 3;21(9):1648-58
Structure (London, England : 1993) 2013 Sep 3;21(9):1648-58
Structure analysis of FAAP24 reveals single-stranded DNA-binding activity and domain functions in DNA damage response.
Wang Y, Han X, Wu F, Leung JW, Lowery MG, Do H, Chen J, Shi C, Tian C, Li L, Gong W
Cell research 2013 Oct;23(10):1215-28
Cell research 2013 Oct;23(10):1215-28
EGFR-activating mutations correlate with a Fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity.
Pfäffle HN, Wang M, Gheorghiu L, Ferraiolo N, Greninger P, Borgmann K, Settleman J, Benes CH, Sequist LV, Zou L, Willers H
Cancer research 2013 Oct 15;73(20):6254-63
Cancer research 2013 Oct 15;73(20):6254-63
Anthracyclines induce DNA damage response-mediated protection against severe sepsis.
Figueiredo N, Chora A, Raquel H, Pejanovic N, Pereira P, Hartleben B, Neves-Costa A, Moita C, Pedroso D, Pinto A, Marques S, Faridi H, Costa P, Gozzelino R, Zhao JL, Soares MP, Gama-Carvalho M, Martinez J, Zhang Q, Döring G, Grompe M, Simas JP, Huber TB, Baltimore D, Gupta V, Green DR, Ferreira JA, Moita LF
Immunity 2013 Nov 14;39(5):874-84
Immunity 2013 Nov 14;39(5):874-84
Reduced FANCD2 influences spontaneous SCE and RAD51 foci formation in uveal melanoma and Fanconi anaemia.
Gravells P, Hoh L, Solovieva S, Patil A, Dudziec E, Rennie IG, Sisley K, Bryant HE
Oncogene 2013 Nov 14;32(46):5338-46
Oncogene 2013 Nov 14;32(46):5338-46
Non-erythroid alpha spectrin prevents telomere dysfunction after DNA interstrand cross-link damage.
Zhang P, Herbig U, Coffman F, Lambert MW
Nucleic acids research 2013 May 1;41(10):5321-40
Nucleic acids research 2013 May 1;41(10):5321-40
Assessment of FANCD2 nuclear foci formation in paraffin-embedded tumors: a potential patient-enrichment strategy for treatment with DNA interstrand crosslinking agents.
Duan W, Gao L, Zhao W, Leon M, Sadee W, Webb A, Resnick K, Wu X, Ramaswamy B, Cohn DE, Shapiro C, Andreassen PR, Otterson GA, Villalona-Calero MA
Translational research : the journal of laboratory and clinical medicine 2013 Mar;161(3):156-64
Translational research : the journal of laboratory and clinical medicine 2013 Mar;161(3):156-64
FANCM and FAAP24 maintain genome stability via cooperative as well as unique functions.
Wang Y, Leung JW, Jiang Y, Lowery MG, Do H, Vasquez KM, Chen J, Wang W, Li L
Molecular cell 2013 Mar 7;49(5):997-1009
Molecular cell 2013 Mar 7;49(5):997-1009
Recruitment of DNA polymerase eta by FANCD2 in the early response to DNA damage.
Fu D, Dudimah FD, Zhang J, Pickering A, Paneerselvam J, Palrasu M, Wang H, Fei P
Cell cycle (Georgetown, Tex.) 2013 Mar 1;12(5):803-9
Cell cycle (Georgetown, Tex.) 2013 Mar 1;12(5):803-9
Senataxin, defective in the neurodegenerative disorder ataxia with oculomotor apraxia 2, lies at the interface of transcription and the DNA damage response.
Yüce Ö, West SC
Molecular and cellular biology 2013 Jan;33(2):406-17
Molecular and cellular biology 2013 Jan;33(2):406-17
Regulation of multiple DNA repair pathways by the Fanconi anemia protein SLX4.
Kim Y, Spitz GS, Veturi U, Lach FP, Auerbach AD, Smogorzewska A
Blood 2013 Jan 3;121(1):54-63
Blood 2013 Jan 3;121(1):54-63
Multifunctionality of the FA pathway.
Hays LE
Blood 2013 Jan 3;121(1):3-4
Blood 2013 Jan 3;121(1):3-4
Rev3, the catalytic subunit of Polζ, is required for maintaining fragile site stability in human cells.
Bhat A, Andersen PL, Qin Z, Xiao W
Nucleic acids research 2013 Feb 1;41(4):2328-39
Nucleic acids research 2013 Feb 1;41(4):2328-39
The SNM1B/APOLLO DNA nuclease functions in resolution of replication stress and maintenance of common fragile site stability.
Mason JM, Das I, Arlt M, Patel N, Kraftson S, Glover TW, Sekiguchi JM
Human molecular genetics 2013 Dec 15;22(24):4901-13
Human molecular genetics 2013 Dec 15;22(24):4901-13
A novel interplay between the Fanconi anemia core complex and ATR-ATRIP kinase during DNA cross-link repair.
Tomida J, Itaya A, Shigechi T, Unno J, Uchida E, Ikura M, Masuda Y, Matsuda S, Adachi J, Kobayashi M, Meetei AR, Maehara Y, Yamamoto K, Kamiya K, Matsuura A, Matsuda T, Ikura T, Ishiai M, Takata M
Nucleic acids research 2013 Aug;41(14):6930-41
Nucleic acids research 2013 Aug;41(14):6930-41
MUS81 promotes common fragile site expression.
Ying S, Minocherhomji S, Chan KL, Palmai-Pallag T, Chu WK, Wass T, Mankouri HW, Liu Y, Hickson ID
Nature cell biology 2013 Aug;15(8):1001-7
Nature cell biology 2013 Aug;15(8):1001-7
CtIP is required to initiate replication-dependent interstrand crosslink repair.
Duquette ML, Zhu Q, Taylor ER, Tsay AJ, Shi LZ, Berns MW, McGowan CH
PLoS genetics 2012;8(11):e1003050
PLoS genetics 2012;8(11):e1003050
Identification of the first ATRIP-deficient patient and novel mutations in ATR define a clinical spectrum for ATR-ATRIP Seckel Syndrome.
Ogi T, Walker S, Stiff T, Hobson E, Limsirichaikul S, Carpenter G, Prescott K, Suri M, Byrd PJ, Matsuse M, Mitsutake N, Nakazawa Y, Vasudevan P, Barrow M, Stewart GS, Taylor AM, O'Driscoll M, Jeggo PA
PLoS genetics 2012;8(11):e1002945
PLoS genetics 2012;8(11):e1002945
UBR2 of the N-end rule pathway is required for chromosome stability via histone ubiquitylation in spermatocytes and somatic cells.
An JY, Kim E, Zakrzewska A, Yoo YD, Jang JM, Han DH, Lee MJ, Seo JW, Lee YJ, Kim TY, de Rooij DG, Kim BY, Kwon YT
PloS one 2012;7(5):e37414
PloS one 2012;7(5):e37414
Regulation of the Fanconi anemia pathway by a CUE ubiquitin-binding domain in the FANCD2 protein.
Rego MA, Kolling FW 4th, Vuono EA, Mauro M, Howlett NG
Blood 2012 Sep 6;120(10):2109-17
Blood 2012 Sep 6;120(10):2109-17
Oxidation-mediated DNA cross-linking contributes to the toxicity of 6-thioguanine in human cells.
Brem R, Karran P
Cancer research 2012 Sep 15;72(18):4787-95
Cancer research 2012 Sep 15;72(18):4787-95
Processing of anthracycline-DNA adducts via DNA replication and interstrand crosslink repair pathways.
Bilardi RA, Kimura KI, Phillips DR, Cutts SM
Biochemical pharmacology 2012 May 1;83(9):1241-50
Biochemical pharmacology 2012 May 1;83(9):1241-50
Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair.
Leung JW, Wang Y, Fong KW, Huen MS, Li L, Chen J
Proceedings of the National Academy of Sciences of the United States of America 2012 Mar 20;109(12):4491-6
Proceedings of the National Academy of Sciences of the United States of America 2012 Mar 20;109(12):4491-6
FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair.
Zhou W, Otto EA, Cluckey A, Airik R, Hurd TW, Chaki M, Diaz K, Lach FP, Bennett GR, Gee HY, Ghosh AK, Natarajan S, Thongthip S, Veturi U, Allen SJ, Janssen S, Ramaswami G, Dixon J, Burkhalter F, Spoendlin M, Moch H, Mihatsch MJ, Verine J, Reade R, Soliman H, Godin M, Kiss D, Monga G, Mazzucco G, Amann K, Artunc F, Newland RC, Wiech T, Zschiedrich S, Huber TB, Friedl A, Slaats GG, Joles JA, Goldschmeding R, Washburn J, Giles RH, Levy S, Smogorzewska A, Hildebrandt F
Nature genetics 2012 Jul 8;44(8):910-5
Nature genetics 2012 Jul 8;44(8):910-5
Bone marrow failure in Fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells.
Ceccaldi R, Parmar K, Mouly E, Delord M, Kim JM, Regairaz M, Pla M, Vasquez N, Zhang QS, Pondarre C, Peffault de Latour R, Gluckman E, Cavazzana-Calvo M, Leblanc T, Larghero J, Grompe M, Socié G, D'Andrea AD, Soulier J
Cell stem cell 2012 Jul 6;11(1):36-49
Cell stem cell 2012 Jul 6;11(1):36-49
Regulation of the activation of the Fanconi anemia pathway by the p21 cyclin-dependent kinase inhibitor.
Rego MA, Harney JA, Mauro M, Shen M, Howlett NG
Oncogene 2012 Jan 19;31(3):366-75
Oncogene 2012 Jan 19;31(3):366-75
Dysregulation of DNA polymerase κ recruitment to replication forks results in genomic instability.
Jones MJ, Colnaghi L, Huang TT
The EMBO journal 2012 Feb 15;31(4):908-18
The EMBO journal 2012 Feb 15;31(4):908-18
The fanconi anemia pathway limits human papillomavirus replication.
Hoskins EE, Morreale RJ, Werner SP, Higginbotham JM, Laimins LA, Lambert PF, Brown DR, Gillison ML, Nuovo GJ, Witte DP, Kim MO, Davies SM, Mehta PA, Butsch Kovacic M, Wikenheiser-Brokamp KA, Wells SI
Journal of virology 2012 Aug;86(15):8131-8
Journal of virology 2012 Aug;86(15):8131-8
MiR-96 downregulates REV1 and RAD51 to promote cellular sensitivity to cisplatin and PARP inhibition.
Wang Y, Huang JW, Calses P, Kemp CJ, Taniguchi T
Cancer research 2012 Aug 15;72(16):4037-46
Cancer research 2012 Aug 15;72(16):4037-46
FAVL impairment of the Fanconi anemia pathway promotes the development of human bladder cancer.
Panneerselvam J, Park HK, Zhang J, Dudimah FD, Zhang P, Wang H, Fei P
Cell cycle (Georgetown, Tex.) 2012 Aug 1;11(15):2947-55
Cell cycle (Georgetown, Tex.) 2012 Aug 1;11(15):2947-55
Non-specific chemical inhibition of the Fanconi anemia pathway sensitizes cancer cells to cisplatin.
Jacquemont C, Simon JA, D'Andrea AD, Taniguchi T
Molecular cancer 2012 Apr 26;11:26
Molecular cancer 2012 Apr 26;11:26
Long range regulation of human FXN gene expression.
Puspasari N, Rowley SM, Gordon L, Lockhart PJ, Ioannou PA, Delatycki MB, Sarsero JP
PloS one 2011;6(7):e22001
PloS one 2011;6(7):e22001
Lac operator repeats generate a traceable fragile site in mammalian cells.
Jacome A, Fernandez-Capetillo O
EMBO reports 2011 Sep 30;12(10):1032-8
EMBO reports 2011 Sep 30;12(10):1032-8
The human DEK oncogene regulates DNA damage response signaling and repair.
Kavanaugh GM, Wise-Draper TM, Morreale RJ, Morrison MA, Gole B, Schwemberger S, Tichy ED, Lu L, Babcock GF, Wells JM, Drissi R, Bissler JJ, Stambrook PJ, Andreassen PR, Wiesmüller L, Wells SI
Nucleic acids research 2011 Sep 1;39(17):7465-76
Nucleic acids research 2011 Sep 1;39(17):7465-76
The Fanconi anemia pathway is downregulated upon macrophage differentiation through two distinct mechanisms.
Lu WT, Lemonidis K, Drayton RM, Nouspikel T
Cell cycle (Georgetown, Tex.) 2011 Oct 1;10(19):3300-10
Cell cycle (Georgetown, Tex.) 2011 Oct 1;10(19):3300-10
Differential roles for Chk1 and FANCD2 in ATR-mediated signalling for psoralen photoactivation-induced senescence.
Hovest MG, Krieg T, Herrmann G
Experimental dermatology 2011 Nov;20(11):883-9
Experimental dermatology 2011 Nov;20(11):883-9
Ovarian surface epitheliectomy in the non-human primate: continued cyclic ovarian function and limited epithelial replacement.
Wright JW, Pejovic T, Jurevic L, Bishop CV, Hobbs T, Stouffer RL
Human reproduction (Oxford, England) 2011 Jun;26(6):1422-30
Human reproduction (Oxford, England) 2011 Jun;26(6):1422-30
Snm1B/Apollo functions in the Fanconi anemia pathway in response to DNA interstrand crosslinks.
Mason JM, Sekiguchi JM
Human molecular genetics 2011 Jul 1;20(13):2549-59
Human molecular genetics 2011 Jul 1;20(13):2549-59
Spontaneous abrogation of the G₂DNA damage checkpoint has clinical benefits but promotes leukemogenesis in Fanconi anemia patients.
Ceccaldi R, Briot D, Larghero J, Vasquez N, Dubois d'Enghien C, Chamousset D, Noguera ME, Waisfisz Q, Hermine O, Pondarre C, Leblanc T, Gluckman E, Joenje H, Stoppa-Lyonnet D, Socié G, Soulier J
The Journal of clinical investigation 2011 Jan;121(1):184-94
The Journal of clinical investigation 2011 Jan;121(1):184-94
Mutations of the SLX4 gene in Fanconi anemia.
Kim Y, Lach FP, Desetty R, Hanenberg H, Auerbach AD, Smogorzewska A
Nature genetics 2011 Feb;43(2):142-6
Nature genetics 2011 Feb;43(2):142-6
SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype.
Stoepker C, Hain K, Schuster B, Hilhorst-Hofstee Y, Rooimans MA, Steltenpool J, Oostra AB, Eirich K, Korthof ET, Nieuwint AW, Jaspers NG, Bettecken T, Joenje H, Schindler D, Rouse J, de Winter JP
Nature genetics 2011 Feb;43(2):138-41
Nature genetics 2011 Feb;43(2):138-41
Patient-derived C-terminal mutation of FANCI causes protein mislocalization and reveals putative EDGE motif function in DNA repair.
Colnaghi L, Jones MJ, Cotto-Rios XM, Schindler D, Hanenberg H, Huang TT
Blood 2011 Feb 17;117(7):2247-56
Blood 2011 Feb 17;117(7):2247-56
The cytomegaloviral protein pUL138 acts as potentiator of tumor necrosis factor (TNF) receptor 1 surface density to enhance ULb'-encoded modulation of TNF-α signaling.
Le VT, Trilling M, Hengel H
Journal of virology 2011 Dec;85(24):13260-70
Journal of virology 2011 Dec;85(24):13260-70
Efficient DNA interstrand crosslinking by 6-thioguanine and UVA radiation.
Brem R, Daehn I, Karran P
DNA repair 2011 Aug 15;10(8):869-76
DNA repair 2011 Aug 15;10(8):869-76
HP1alpha recruitment to DNA damage by p150CAF-1 promotes homologous recombination repair.
Baldeyron C, Soria G, Roche D, Cook AJ, Almouzni G
The Journal of cell biology 2011 Apr 4;193(1):81-95
The Journal of cell biology 2011 Apr 4;193(1):81-95
A first genome assembly of the barley fungal pathogen Pyrenophora teres f. teres.
Ellwood SR, Liu Z, Syme RA, Lai Z, Hane JK, Keiper F, Moffat CS, Oliver RP, Friesen TL
Genome biology 2010;11(11):R109
Genome biology 2010;11(11):R109
Recycling cohesin rings by deacetylation.
Rivera T, Losada A
Molecular cell 2010 Sep 10;39(5):657-9
Molecular cell 2010 Sep 10;39(5):657-9
Multicellular development in a choanoflagellate.
Fairclough SR, Dayel MJ, King N
Current biology : CB 2010 Oct 26;20(20):R875-6
Current biology : CB 2010 Oct 26;20(20):R875-6
Control of bacterial iron homeostasis by manganese.
Puri S, Hohle TH, O'Brian MR
Proceedings of the National Academy of Sciences of the United States of America 2010 Jun 8;107(23):10691-5
Proceedings of the National Academy of Sciences of the United States of America 2010 Jun 8;107(23):10691-5
A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.
Smogorzewska A, Desetty R, Saito TT, Schlabach M, Lach FP, Sowa ME, Clark AB, Kunkel TA, Harper JW, Colaiácovo MP, Elledge SJ
Molecular cell 2010 Jul 9;39(1):36-47
Molecular cell 2010 Jul 9;39(1):36-47
Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2.
MacKay C, Déclais AC, Lundin C, Agostinho A, Deans AJ, MacArtney TJ, Hofmann K, Gartner A, West SC, Helleday T, Lilley DM, Rouse J
Cell 2010 Jul 9;142(1):65-76
Cell 2010 Jul 9;142(1):65-76
Constitutive activation of caspase-3 and Poly ADP ribose polymerase cleavage in fanconi anemia cells.
Lyakhovich A, Surrallés J
Molecular cancer research : MCR 2010 Jan;8(1):46-56
Molecular cancer research : MCR 2010 Jan;8(1):46-56
Functional interaction between the Fanconi Anemia D2 protein and proliferating cell nuclear antigen (PCNA) via a conserved putative PCNA interaction motif.
Howlett NG, Harney JA, Rego MA, Kolling FW 4th, Glover TW
The Journal of biological chemistry 2009 Oct 16;284(42):28935-42
The Journal of biological chemistry 2009 Oct 16;284(42):28935-42
Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells.
Raya A, Rodríguez-Pizà I, Guenechea G, Vassena R, Navarro S, Barrero MJ, Consiglio A, Castellà M, Río P, Sleep E, González F, Tiscornia G, Garreta E, Aasen T, Veiga A, Verma IM, Surrallés J, Bueren J, Izpisúa Belmonte JC
Nature 2009 Jul 2;460(7251):53-9
Nature 2009 Jul 2;460(7251):53-9
XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair.
Bhagwat N, Olsen AL, Wang AT, Hanada K, Stuckert P, Kanaar R, D'Andrea A, Niedernhofer LJ, McHugh PJ
Molecular and cellular biology 2009 Dec;29(24):6427-37
Molecular and cellular biology 2009 Dec;29(24):6427-37
FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia.
Deans AJ, West SC
Molecular cell 2009 Dec 25;36(6):943-53
Molecular cell 2009 Dec 25;36(6):943-53
Biomarkers and mechanisms of FANCD2 function.
Willers H, Kachnic LA, Luo CM, Li L, Purschke M, Borgmann K, Held KD, Powell SN
Journal of biomedicine & biotechnology 2008;2008:821529
Journal of biomedicine & biotechnology 2008;2008:821529
HES1 is a novel interactor of the Fanconi anemia core complex.
Tremblay CS, Huang FF, Habi O, Huard CC, Godin C, Lévesque G, Carreau M
Blood 2008 Sep 1;112(5):2062-70
Blood 2008 Sep 1;112(5):2062-70
Hsp90 regulates the Fanconi anemia DNA damage response pathway.
Oda T, Hayano T, Miyaso H, Takahashi N, Yamashita T
Blood 2007 Jun 1;109(11):5016-26
Blood 2007 Jun 1;109(11):5016-26
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase.
Kolas NK, Chapman JR, Nakada S, Ylanko J, Chahwan R, Sweeney FD, Panier S, Mendez M, Wildenhain J, Thomson TM, Pelletier L, Jackson SP, Durocher D
Science (New York, N.Y.) 2007 Dec 7;318(5856):1637-40
Science (New York, N.Y.) 2007 Dec 7;318(5856):1637-40
Proteasome function is required for DNA damage response and fanconi anemia pathway activation.
Jacquemont C, Taniguchi T
Cancer research 2007 Aug 1;67(15):7395-405
Cancer research 2007 Aug 1;67(15):7395-405
HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability.
Collis SJ, Barber LJ, Clark AJ, Martin JS, Ward JD, Boulton SJ
Nature cell biology 2007 Apr;9(4):391-401
Nature cell biology 2007 Apr;9(4):391-401
Young patients with oral squamous cell carcinoma: study of the involvement of GSTP1 and deregulation of the Fanconi anemia genes.
Tremblay S, Pintor Dos Reis P, Bradley G, Galloni NN, Perez-Ordonez B, Freeman J, Brown D, Gilbert R, Gullane P, Irish J, Kamel-Reid S
Archives of otolaryngology--head & neck surgery 2006 Sep;132(9):958-66
Archives of otolaryngology--head & neck surgery 2006 Sep;132(9):958-66
Defective mitochondrial peroxiredoxin-3 results in sensitivity to oxidative stress in Fanconi anemia.
Mukhopadhyay SS, Leung KS, Hicks MJ, Hastings PJ, Youssoufian H, Plon SE
The Journal of cell biology 2006 Oct 23;175(2):225-35
The Journal of cell biology 2006 Oct 23;175(2):225-35
Activation of the Fanconi anemia/BRCA pathway and recombination repair in the cellular response to solar ultraviolet light.
Dunn J, Potter M, Rees A, Rünger TM
Cancer research 2006 Dec 1;66(23):11140-7
Cancer research 2006 Dec 1;66(23):11140-7
Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks.
Bekker-Jensen S, Lukas C, Kitagawa R, Melander F, Kastan MB, Bartek J, Lukas J
The Journal of cell biology 2006 Apr 24;173(2):195-206
The Journal of cell biology 2006 Apr 24;173(2):195-206
Nbs1 is required for ATR-dependent phosphorylation events.
Stiff T, Reis C, Alderton GK, Woodbine L, O'Driscoll M, Jeggo PA
The EMBO journal 2005 Jan 12;24(1):199-208
The EMBO journal 2005 Jan 12;24(1):199-208
A Rad50-dependent pathway of DNA repair is deficient in Fanconi anemia fibroblasts.
Donahue SL, Campbell C
Nucleic acids research 2004;32(10):3248-57
Nucleic acids research 2004;32(10):3248-57
Human SNM1B is required for normal cellular response to both DNA interstrand crosslink-inducing agents and ionizing radiation.
Demuth I, Digweed M, Concannon P
Oncogene 2004 Nov 11;23(53):8611-8
Oncogene 2004 Nov 11;23(53):8611-8
Repair kinetics of genomic interstrand DNA cross-links: evidence for DNA double-strand break-dependent activation of the Fanconi anemia/BRCA pathway.
Rothfuss A, Grompe M
Molecular and cellular biology 2004 Jan;24(1):123-34
Molecular and cellular biology 2004 Jan;24(1):123-34
Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors.
Taniguchi T, Tischkowitz M, Ameziane N, Hodgson SV, Mathew CG, Joenje H, Mok SC, D'Andrea AD
Nature medicine 2003 May;9(5):568-74
Nature medicine 2003 May;9(5):568-74
FANCF methylation contributes to chemoselectivity in ovarian cancer.
Olopade OI, Wei M
Cancer cell 2003 May;3(5):417-20
Cancer cell 2003 May;3(5):417-20
Nonerythroid alphaII spectrin is required for recruitment of FANCA and XPF to nuclear foci induced by DNA interstrand cross-links.
Sridharan D, Brown M, Lambert WC, McMahon LW, Lambert MW
Journal of cell science 2003 Mar 1;116(Pt 5):823-35
Journal of cell science 2003 Mar 1;116(Pt 5):823-35
Acquired FANCA dysfunction and cytogenetic instability in adult acute myelogenous leukemia.
Lensch MW, Tischkowitz M, Christianson TA, Reifsteck CA, Speckhart SA, Jakobs PM, O'Dwyer ME, Olson SB, Le Beau MM, Hodgson SV, Mathew CG, Larson RA, Bagby GC Jr
Blood 2003 Jul 1;102(1):7-16
Blood 2003 Jul 1;102(1):7-16
S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51.
Taniguchi T, Garcia-Higuera I, Andreassen PR, Gregory RC, Grompe M, D'Andrea AD
Blood 2002 Oct 1;100(7):2414-20
Blood 2002 Oct 1;100(7):2414-20
Attenuation of the formation of DNA-repair foci containing RAD51 in Fanconi anaemia.
Digweed M, Rothe S, Demuth I, Scholz R, Schindler D, Stumm M, Grompe M, Jordan A, Sperling K
Carcinogenesis 2002 Jul;23(7):1121-6
Carcinogenesis 2002 Jul;23(7):1121-6
Human alpha spectrin II and the FANCA, FANCC, and FANCG proteins bind to DNA containing psoralen interstrand cross-links.
McMahon LW, Sangerman J, Goodman SR, Kumaresan K, Lambert MW
Biochemistry 2001 Jun 19;40(24):7025-34
Biochemistry 2001 Jun 19;40(24):7025-34
Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway.
Garcia-Higuera I, Taniguchi T, Ganesan S, Meyn MS, Timmers C, Hejna J, Grompe M, D'Andrea AD
Molecular cell 2001 Feb;7(2):249-62
Molecular cell 2001 Feb;7(2):249-62
Targeted disruption of the murine Fanconi anemia gene, Fancg/Xrcc9.
Yang Y, Kuang Y, Montes De Oca R, Hays T, Moreau L, Lu N, Seed B, D'Andrea AD
Blood 2001 Dec 1;98(12):3435-40
Blood 2001 Dec 1;98(12):3435-40
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Supportive validation
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- FancD2 colocalizes in vivo with another protein in U2OS cells after cell exposure to IR. Proliferating U2OS cells were exposed to 10 Gy of IR and double -color immunofluorescence staining was performed after 8 h. Images were captured in a Kodak digital image system on a Leica fluorescence microscope.
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- FancD2 colocalizes in vivo with another protein in SiHa cells after cell exposure to IR. Proliferating SiHa cells were exposed to 10 Gy of IR and double -color immunofluorescence staining was performed after 8 h. Images were captured in a Kodak digital image system on a Leica fluorescence microscope.
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- antibodies-online (provider)
- Main image
- Experimental details
- IHC
