611301

antibody from BioLegend
Targeting: APC DP2, DP2.5, DP3, PPP1R46
Provider product page for 611301
Western blot

Antibody data

Product number
611301 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#611301, RRID:AB_2227127
Product name
Purified anti-APC7
Antibody type
Polyclonal
Antigen
Recombinant (partial), N-terminal
Description
APC7 (anaphase-promoting complex subunit 7) is a member of the E3 enzyme family. This protein contains TPR repeats and has a molecular weight of approximately 63 kD. The APC7 protein is located in the nucleus during interphase and the centrosome during metaphase/anaphase. This protein probably recruits Cdh1 into the APC complex. The APC7 protein functions with other members of the APC complex as a multisubunit cell cycle ubiquitin ligase, and a regulator of sister chromatid separation by degrading securins. In addition, this protein functions in ubiquitin-dependent cyclin catabolism, metaphase/anaphase transition, and spindle elongation. The APC7 protein comprises one subunit of the anaphase promoting complex including APC1-8, and other probable complex proteins APC9-11, Cdc26, Mnd2, Swm1. The APC complex is inactivated by protein kinase A and is activated by CDC20 and Cdh1.
Reactivity
Human
Host
Rabbit
Conjugate
Unconjugated
Vial size
50 µl
Storage
Upon receipt, store frozen at -20° C.
APC protein structure - 611301 shown in red.