Ab089133

antibody from Aladdin Scientific Corporation

Targeting: APC DP2, DP2.5, DP3, PPP1R46

Western blot (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Antibody Data

Product number

Ab089133

Provider

Aladdin Scientific Corporation

Product name

Recombinant APC Antibody

Antibody type

Recombinant

Description

Rabbit anti Human APC Antibody, Recombinant (R06-2E4), could be used for WB, IF, ICC and so on.Application:WB: 1/500-1/1000IF: 1/50-1/200Protein functionTumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Antigen sequence

AA 72-90


Antibody clone number

R06-2E4

Vial size

100μl,10μl,1ml,50μl

Concentration

1,4 mg/ml

Storage

Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.