Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS6892 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- LCN2 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human LCN2.
- Description
- Lipocalin-2, a member of the lipocalin family of proteins, was originally identified as a gelatinase-associated component of neutrophil secretory granules. Lipocalin-2 is involved in innate immunity, iron homeostasis, and apoptosis. Lipocalin-2 limits bacterial growth by binding to bacterial siderophores and sequestering iron. In mammalian cells, iron-loaded lipocalin-2 binds to its receptor, 24p3R, and is internalized, thereby releasing iron and increasing the intracellular iron concentration. Conversely, iron-free lipocalin-2 promotes apoptosis. Lipocalin-2 is also expressed in adipose tissue and promotes insulin resistance in cultured mouse adipocytes.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- Western blot analysis of extracts of SW480 cell lines, using LCN2 antibody.