Antibody data
- Antibody Data
- Antigen structure
- References [49]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 14730-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14730-1-AP, RRID:AB_2210497
- Product name
- UCHL1/PGP9.5 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated UCHL1/PGP9.5 antibody (Cat. #14730-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Mouse model of voluntary movement deficits induced by needlestick injuries to the primary motor cortex.
Lidocaine prevents breast cancer growth by targeting neuronatin to inhibit nerve fibers formation.
Expansion of murine and human olfactory epithelium/mucosa colonies and generation of mature olfactory sensory neurons under chemically defined conditions.
The type 3 adenylyl cyclase is crucial for intestinal mucosal neural network in the gut lamina propria.
Metabolic stress drives sympathetic neuropathy within the liver.
Chitinase-Like Protein Ym2 (Chil4) Regulates Regeneration of the Olfactory Epithelium via Interaction with Inflammation.
Increased Expression of Thymic Stromal Lymphopoietin in Chronic Constriction Injury of Rat Nerve.
Differential effects of minocycline on microvascular complications in murine models of type 1 and type 2 diabetes.
Upper motor neurons are a target for gene therapy and UCHL1 is necessary and sufficient to improve cellular integrity of diseased upper motor neurons.
Live visualization of a functional RET-EGFP chimeric receptor in homozygous knock-in mice.
Sarm1-mediated neurodegeneration within the enteric nervous system protects against local inflammation of the colon.
Yuan‑zhi‑san inhibits tau protein aggregation in an Aβ(1‑40)‑induced Alzheimer's disease rat model via the ubiquitin‑proteasome system.
Age-Dependent Activation and Neuronal Differentiation of Lgr5+ Basal Cells in Injured Olfactory Epithelium via Notch Signaling Pathway.
Differential Effects of Empagliflozin on Microvascular Complications in Murine Models of Type 1 and Type 2 Diabetes.
A missense point mutation in nerve growth factor (NGFR100W) results in selective peripheral sensory neuropathy.
Local sympathetic innervations modulate the lung innate immune responses.
Inhibition of UCHL1 by LDN-57444 attenuates Ang II-Induced atrial fibrillation in mice.
Kaposi's Sarcoma-Associated Herpesvirus Infection Induces the Expression of Neuroendocrine Genes in Endothelial Cells.
Ubiquitin C-terminal hydrolase L1 (UCHL1) regulates post-myocardial infarction cardiac fibrosis through glucose-regulated protein of 78 kDa (GRP78).
Peripheral FGFR1 Regulates Myofascial Pain in Rats via the PI3K/AKT Pathway.
A leptin-BDNF pathway regulating sympathetic innervation of adipose tissue.
Neural Regeneration/Remodeling in Engineered Coronal Pulp Tissue in the Rat Molar.
Sodium-glucose co-transporter (SGLT) inhibitor restores lost axonal varicosities of the myenteric plexus in a mouse model of high-fat diet-induced obesity.
MDM2 inhibition-mediated autophagy contributes to the pro-apoptotic effect of berberine in p53-null leukemic cells.
Plakoglobin is involved in cytoskeletal rearrangement of podocytes under the regulation of UCH-L1.
Toll-like receptors and inflammation in metabolic neuropathy; a role in early versus late disease?
Activation of KCNQ Channels Prevents Paclitaxel-Induced Peripheral Neuropathy and Associated Neuropathic Pain.
Panicle-Shaped Sympathetic Architecture in the Spleen Parenchyma Modulates Antibacterial Innate Immunity.
3D-Imaging of Whole Neuronal and Vascular Networks of the Human Dental Pulp via CLARITY and Light Sheet Microscopy.
Possible involvement of peripheral TRP channels in the hydrogen sulfide-induced hyperalgesia in diabetic rats.
Mitochondrial uncoupling has no effect on microvascular complications in type 2 diabetes.
Colonic electrical stimulation improves colonic transit in rotenone-induced Parkinson's disease model through affecting enteric neurons.
Aryl Hydrocarbon Receptor Interacting Protein Maintains Germinal Center B Cells through Suppression of BCL6 Degradation.
Targeted Mutation (R100W) of the Gene Encoding NGF Leads to Deficits in the Peripheral Sensory Nervous System.
UCH-L1 inhibition aggravates mossy fiber sprouting in the pentylenetetrazole kindling model.
Changes in proteome solubility indicate widespread proteostatic disruption in mouse models of neurodegenerative disease.
Juvenile murine models of prediabetes and type 2 diabetes develop neuropathy.
Aging-dependent decrease in the numbers of enteric neurons, interstitial cells of Cajal and expression of connexin43 in various regions of gastrointestinal tract.
The Neuroregenerative Capacity of Olfactory Stem Cells Is Not Limitless: Implications for Aging.
Dense Intra-adipose Sympathetic Arborizations Are Essential for Cold-Induced Beiging of Mouse White Adipose Tissue.
Antibody incubation at 37°C improves fluorescent immunolabeling in free-floating thick tissue sections.
Alpha7 nicotinic acetylcholine receptor is required for amyloid pathology in brain endothelial cells induced by Glycoprotein 120, methamphetamine and nicotine.
Injury Induces Endogenous Reprogramming and Dedifferentiation of Neuronal Progenitors to Multipotency.
Adeno-associated virus serotype rh10 is a useful gene transfer vector for sensory nerves that innervate bone in immunodeficient mice.
Absence of UCHL 1 function leads to selective motor neuropathy.
Visualization of Sensory Neurons and Their Projections in an Upper Motor Neuron Reporter Line.
Corticospinal Motor Neurons Are Susceptible to Increased ER Stress and Display Profound Degeneration in the Absence of UCHL1 Function.
Circulating brain microvascular endothelial cells (cBMECs) as potential biomarkers of the blood-brain barrier disorders caused by microbial and non-microbial factors.
Production of polyclonal anti-dUCH (Drosophila ubiquitin carboxyl-terminal hydrolase) antibodies.
Liu XT, Liu CM, Teng ZQ
Journal of neuroscience methods 2022 Jan 1;365:109380
Journal of neuroscience methods 2022 Jan 1;365:109380
Lidocaine prevents breast cancer growth by targeting neuronatin to inhibit nerve fibers formation.
Li B, Xu H, He C, Zou W, Tu Y
The Journal of toxicological sciences 2021;46(7):329-339
The Journal of toxicological sciences 2021;46(7):329-339
Expansion of murine and human olfactory epithelium/mucosa colonies and generation of mature olfactory sensory neurons under chemically defined conditions.
Ren W, Wang L, Zhang X, Feng X, Zhuang L, Jiang N, Xu R, Li X, Wang P, Sun X, Yu H, Yu Y
Theranostics 2021;11(2):684-699
Theranostics 2021;11(2):684-699
The type 3 adenylyl cyclase is crucial for intestinal mucosal neural network in the gut lamina propria.
Zhou K, Zhou Y, Yang D, Chen T, Liu X, Li S, Wang Z
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2021 Sep;33(9):e14140
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2021 Sep;33(9):e14140
Metabolic stress drives sympathetic neuropathy within the liver.
Liu K, Yang L, Wang G, Liu J, Zhao X, Wang Y, Li J, Yang J
Cell metabolism 2021 Mar 2;33(3):666-675.e4
Cell metabolism 2021 Mar 2;33(3):666-675.e4
Chitinase-Like Protein Ym2 (Chil4) Regulates Regeneration of the Olfactory Epithelium via Interaction with Inflammation.
Wang L, Ren W, Li X, Zhang X, Tian H, Bhattarai JP, Challis RC, Lee AC, Zhao S, Yu H, Ma M, Yu Y
The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Jun 30;41(26):5620-5637
The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Jun 30;41(26):5620-5637
Increased Expression of Thymic Stromal Lymphopoietin in Chronic Constriction Injury of Rat Nerve.
Wu CH, Lu CC, Huang CL, Wu MK, Lu YY
International journal of molecular sciences 2021 Jul 1;22(13)
International journal of molecular sciences 2021 Jul 1;22(13)
Differential effects of minocycline on microvascular complications in murine models of type 1 and type 2 diabetes.
Eid SA, O'Brien PD, Hinder LM, Hayes JM, Mendelson FE, Zhang H, Narayanan S, Abcouwer SF, Brosius FC 3rd, Pennathur S, Savelieff MG, Feldman EL
Journal of translational science 2021 Feb;7(1)
Journal of translational science 2021 Feb;7(1)
Upper motor neurons are a target for gene therapy and UCHL1 is necessary and sufficient to improve cellular integrity of diseased upper motor neurons.
Genç B, Jara JH, Sanchez SS, Lagrimas AKB, Gözütok Ö, Koçak N, Zhu Y, Hande Özdinler P
Gene therapy 2021 Dec 2;
Gene therapy 2021 Dec 2;
Live visualization of a functional RET-EGFP chimeric receptor in homozygous knock-in mice.
Sunardi M, Ito K, Enomoto H
Development, growth & differentiation 2021 Aug;63(6):285-294
Development, growth & differentiation 2021 Aug;63(6):285-294
Sarm1-mediated neurodegeneration within the enteric nervous system protects against local inflammation of the colon.
Sun Y, Wang Q, Wang Y, Ren W, Cao Y, Li J, Zhou X, Fu W, Yang J
Protein & cell 2021 Aug;12(8):621-638
Protein & cell 2021 Aug;12(8):621-638
Yuan‑zhi‑san inhibits tau protein aggregation in an Aβ(1‑40)‑induced Alzheimer's disease rat model via the ubiquitin‑proteasome system.
Li B, Xie PJ, Hao YW, Guo Y, Yu JR, Gong DY, Guo J, Zeng JH, Zhang Y
Molecular medicine reports 2021 Apr;23(4)
Molecular medicine reports 2021 Apr;23(4)
Age-Dependent Activation and Neuronal Differentiation of Lgr5+ Basal Cells in Injured Olfactory Epithelium via Notch Signaling Pathway.
Li X, Tong M, Wang L, Qin Y, Yu H, Yu Y
Frontiers in aging neuroscience 2020;12:602688
Frontiers in aging neuroscience 2020;12:602688
Differential Effects of Empagliflozin on Microvascular Complications in Murine Models of Type 1 and Type 2 Diabetes.
Eid SA, O'Brien PD, Hinder LM, Hayes JM, Mendelson FE, Zhang H, Zeng L, Kretzler K, Narayanan S, Abcouwer SF, Brosius Iii FC 3rd, Pennathur S, Savelieff MG, Feldman EL
Biology 2020 Oct 22;9(11)
Biology 2020 Oct 22;9(11)
A missense point mutation in nerve growth factor (NGFR100W) results in selective peripheral sensory neuropathy.
Yang W, Sung K, Xu W, Rodriguez MJ, Wu AC, Santos SA, Fang S, Uber RK, Dong SX, Guillory BC, Orain X, Raus J, Jolivalt C, Calcutt N, Rissman RA, Ding J, Wu C
Progress in neurobiology 2020 Nov;194:101886
Progress in neurobiology 2020 Nov;194:101886
Local sympathetic innervations modulate the lung innate immune responses.
Liu T, Yang L, Han X, Ding X, Li J, Yang J
Science advances 2020 May;6(20):eaay1497
Science advances 2020 May;6(20):eaay1497
Inhibition of UCHL1 by LDN-57444 attenuates Ang II-Induced atrial fibrillation in mice.
Bi HL, Zhang YL, Yang J, Shu Q, Yang XL, Yan X, Chen C, Li Z, Li HH
Hypertension research : official journal of the Japanese Society of Hypertension 2020 Mar;43(3):168-177
Hypertension research : official journal of the Japanese Society of Hypertension 2020 Mar;43(3):168-177
Kaposi's Sarcoma-Associated Herpesvirus Infection Induces the Expression of Neuroendocrine Genes in Endothelial Cells.
Valiya Veettil M, Krishna G, Roy A, Ghosh A, Dutta D, Kumar B, Chakraborty S, Anju TR, Sharma-Walia N, Chandran B
Journal of virology 2020 Mar 31;94(8)
Journal of virology 2020 Mar 31;94(8)
Ubiquitin C-terminal hydrolase L1 (UCHL1) regulates post-myocardial infarction cardiac fibrosis through glucose-regulated protein of 78 kDa (GRP78).
Lei Q, Yi T, Li H, Yan Z, Lv Z, Li G, Wang Y
Scientific reports 2020 Jun 30;10(1):10604
Scientific reports 2020 Jun 30;10(1):10604
Peripheral FGFR1 Regulates Myofascial Pain in Rats via the PI3K/AKT Pathway.
Zhang M, Jin F, Zhu Y, Qi F
Neuroscience 2020 Jun 1;436:1-10
Neuroscience 2020 Jun 1;436:1-10
A leptin-BDNF pathway regulating sympathetic innervation of adipose tissue.
Wang P, Loh KH, Wu M, Morgan DA, Schneeberger M, Yu X, Chi J, Kosse C, Kim D, Rahmouni K, Cohen P, Friedman J
Nature 2020 Jul;583(7818):839-844
Nature 2020 Jul;583(7818):839-844
Neural Regeneration/Remodeling in Engineered Coronal Pulp Tissue in the Rat Molar.
Sone PP, Kaneko T, Zaw SYM, Sueyama Y, Gu B, Murano H, Zaw ZCT, Okada Y, Han P, Katsube KI, Okiji T
Journal of endodontics 2020 Jul;46(7):943-949
Journal of endodontics 2020 Jul;46(7):943-949
Sodium-glucose co-transporter (SGLT) inhibitor restores lost axonal varicosities of the myenteric plexus in a mouse model of high-fat diet-induced obesity.
Shimo S, Saitoh S, Nguyen HB, Thai TQ, Ikutomo M, Muramatsu K, Ohno N
Scientific reports 2020 Jul 23;10(1):12372
Scientific reports 2020 Jul 23;10(1):12372
MDM2 inhibition-mediated autophagy contributes to the pro-apoptotic effect of berberine in p53-null leukemic cells.
Liu J, Zhu Z, Liu Y, Wei L, Li B, Mao F, Zhang J, Wang Y, Liu Y
Life sciences 2020 Feb 1;242:117228
Life sciences 2020 Feb 1;242:117228
Plakoglobin is involved in cytoskeletal rearrangement of podocytes under the regulation of UCH-L1.
Fang Y, Li F, Qi C, Mao X, Xu Y, Zhao Z, Wu H, Zhang Z
Biochemical and biophysical research communications 2020 Aug 13;529(1):112-118
Biochemical and biophysical research communications 2020 Aug 13;529(1):112-118
Toll-like receptors and inflammation in metabolic neuropathy; a role in early versus late disease?
Elzinga S, Murdock BJ, Guo K, Hayes JM, Tabbey MA, Hur J, Feldman EL
Experimental neurology 2019 Oct;320:112967
Experimental neurology 2019 Oct;320:112967
Activation of KCNQ Channels Prevents Paclitaxel-Induced Peripheral Neuropathy and Associated Neuropathic Pain.
Li L, Li J, Zuo Y, Dang D, Frost JA, Yang Q
The journal of pain 2019 May;20(5):528-539
The journal of pain 2019 May;20(5):528-539
Panicle-Shaped Sympathetic Architecture in the Spleen Parenchyma Modulates Antibacterial Innate Immunity.
Ding X, Wang H, Qian X, Han X, Yang L, Cao Y, Wang Q, Yang J
Cell reports 2019 Jun 25;27(13):3799-3807.e3
Cell reports 2019 Jun 25;27(13):3799-3807.e3
3D-Imaging of Whole Neuronal and Vascular Networks of the Human Dental Pulp via CLARITY and Light Sheet Microscopy.
França CM, Riggers R, Muschler JL, Widbiller M, Lococo PM, Diogenes A, Bertassoni LE
Scientific reports 2019 Jul 26;9(1):10860
Scientific reports 2019 Jul 26;9(1):10860
Possible involvement of peripheral TRP channels in the hydrogen sulfide-induced hyperalgesia in diabetic rats.
Roa-Coria JE, Pineda-Farias JB, Barragán-Iglesias P, Quiñonez-Bastidas GN, Zúñiga-Romero Á, Huerta-Cruz JC, Reyes-García JG, Flores-Murrieta FJ, Granados-Soto V, Rocha-González HI
BMC neuroscience 2019 Jan 3;20(1):1
BMC neuroscience 2019 Jan 3;20(1):1
Mitochondrial uncoupling has no effect on microvascular complications in type 2 diabetes.
Hinder LM, Sas KM, O'Brien PD, Backus C, Kayampilly P, Hayes JM, Lin CM, Zhang H, Shanmugam S, Rumora AE, Abcouwer SF, Brosius FC 3rd, Pennathur S, Feldman EL
Scientific reports 2019 Jan 29;9(1):881
Scientific reports 2019 Jan 29;9(1):881
Colonic electrical stimulation improves colonic transit in rotenone-induced Parkinson's disease model through affecting enteric neurons.
Bu J, Qiao X, He Y, Liu J
Life sciences 2019 Aug 15;231:116581
Life sciences 2019 Aug 15;231:116581
Aryl Hydrocarbon Receptor Interacting Protein Maintains Germinal Center B Cells through Suppression of BCL6 Degradation.
Sun D, Stopka-Farooqui U, Barry S, Aksoy E, Parsonage G, Vossenkämper A, Capasso M, Wan X, Norris S, Marshall JL, Clear A, Gribben J, MacDonald TT, Buckley CD, Korbonits M, Haworth O
Cell reports 2019 Apr 30;27(5):1461-1471.e4
Cell reports 2019 Apr 30;27(5):1461-1471.e4
Targeted Mutation (R100W) of the Gene Encoding NGF Leads to Deficits in the Peripheral Sensory Nervous System.
Yang W, Sung K, Zhou F, Xu W, Rissman RA, Ding J, Wu C
Frontiers in aging neuroscience 2018;10:373
Frontiers in aging neuroscience 2018;10:373
UCH-L1 inhibition aggravates mossy fiber sprouting in the pentylenetetrazole kindling model.
Wen Y, Wu Q, Shi Q, Xie Y, Dan W, Chen Y, Ma L
Biochemical and biophysical research communications 2018 Sep 18;503(4):2312-2318
Biochemical and biophysical research communications 2018 Sep 18;503(4):2312-2318
Changes in proteome solubility indicate widespread proteostatic disruption in mouse models of neurodegenerative disease.
Pace MC, Xu G, Fromholt S, Howard J, Crosby K, Giasson BI, Lewis J, Borchelt DR
Acta neuropathologica 2018 Dec;136(6):919-938
Acta neuropathologica 2018 Dec;136(6):919-938
Juvenile murine models of prediabetes and type 2 diabetes develop neuropathy.
O'Brien PD, Hinder LM, Rumora AE, Hayes JM, Dauch JR, Backus C, Mendelson FE, Feldman EL
Disease models & mechanisms 2018 Dec 18;11(12)
Disease models & mechanisms 2018 Dec 18;11(12)
Aging-dependent decrease in the numbers of enteric neurons, interstitial cells of Cajal and expression of connexin43 in various regions of gastrointestinal tract.
Sun T, Li D, Hu S, Huang L, Sun H, Yang S, Wu B, Ji F, Zhou D
Aging 2018 Dec 11;10(12):3851-3865
Aging 2018 Dec 11;10(12):3851-3865
The Neuroregenerative Capacity of Olfactory Stem Cells Is Not Limitless: Implications for Aging.
Child KM, Herrick DB, Schwob JE, Holbrook EH, Jang W
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Aug 1;38(31):6806-6824
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Aug 1;38(31):6806-6824
Dense Intra-adipose Sympathetic Arborizations Are Essential for Cold-Induced Beiging of Mouse White Adipose Tissue.
Jiang H, Ding X, Cao Y, Wang H, Zeng W
Cell metabolism 2017 Oct 3;26(4):686-692.e3
Cell metabolism 2017 Oct 3;26(4):686-692.e3
Antibody incubation at 37°C improves fluorescent immunolabeling in free-floating thick tissue sections.
Xiao X, Feng YP, Du B, Sun HR, Ding YQ, Qi JG
BioTechniques 2017 Mar 1;62(3):115-122
BioTechniques 2017 Mar 1;62(3):115-122
Alpha7 nicotinic acetylcholine receptor is required for amyloid pathology in brain endothelial cells induced by Glycoprotein 120, methamphetamine and nicotine.
Liu L, Yu J, Li L, Zhang B, Liu L, Wu CH, Jong A, Mao DA, Huang SH
Scientific reports 2017 Jan 11;7:40467
Scientific reports 2017 Jan 11;7:40467
Injury Induces Endogenous Reprogramming and Dedifferentiation of Neuronal Progenitors to Multipotency.
Lin B, Coleman JH, Peterson JN, Zunitch MJ, Jang W, Herrick DB, Schwob JE
Cell stem cell 2017 Dec 7;21(6):761-774.e5
Cell stem cell 2017 Dec 7;21(6):761-774.e5
Adeno-associated virus serotype rh10 is a useful gene transfer vector for sensory nerves that innervate bone in immunodeficient mice.
Park SH, Eber MR, Tsuzuki S, Booker ME, Sunil AG, Widner DB, Parker RA, Peters CM, Shiozawa Y
Scientific reports 2017 Dec 12;7(1):17428
Scientific reports 2017 Dec 12;7(1):17428
Absence of UCHL 1 function leads to selective motor neuropathy.
Genç B, Jara JH, Schultz MC, Manuel M, Stanford MJ, Gautam M, Klessner JL, Sekerkova G, Heller DB, Cox GA, Heckman CJ, DiDonato CJ, Özdinler PH
Annals of clinical and translational neurology 2016 May;3(5):331-45
Annals of clinical and translational neurology 2016 May;3(5):331-45
Visualization of Sensory Neurons and Their Projections in an Upper Motor Neuron Reporter Line.
Genç B, Lagrimas AK, Kuru P, Hess R, Tu MW, Menichella DM, Miller RJ, Paller AS, Özdinler PH
PloS one 2015;10(7):e0132815
PloS one 2015;10(7):e0132815
Corticospinal Motor Neurons Are Susceptible to Increased ER Stress and Display Profound Degeneration in the Absence of UCHL1 Function.
Jara JH, Genç B, Cox GA, Bohn MC, Roos RP, Macklis JD, Ulupınar E, Özdinler PH
Cerebral cortex (New York, N.Y. : 1991) 2015 Nov;25(11):4259-72
Cerebral cortex (New York, N.Y. : 1991) 2015 Nov;25(11):4259-72
Circulating brain microvascular endothelial cells (cBMECs) as potential biomarkers of the blood-brain barrier disorders caused by microbial and non-microbial factors.
Huang SH, Wang L, Chi F, Wu CH, Cao H, Zhang A, Jong A
PloS one 2013;8(4):e62164
PloS one 2013;8(4):e62164
Production of polyclonal anti-dUCH (Drosophila ubiquitin carboxyl-terminal hydrolase) antibodies.
Tram NT, Trang NT, Thao DT, Thuoc TL
Monoclonal antibodies in immunodiagnosis and immunotherapy 2013 Apr;32(2):105-12
Monoclonal antibodies in immunodiagnosis and immunotherapy 2013 Apr;32(2):105-12
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The UCHL1/PGP9.5 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human UCHL1/PGP9.5. This antibody recognizes human,mouse,rat antigen. The UCHL1/PGP9.5 antibody has been validated for the following applications: ELISA, WB analysis.