Ab088039

antibody from Aladdin Scientific
Targeting: ALDH1A1 ALDH1, PUMB1, RALDH1
Provider product page for Ab088039

Antibody data

Product number
Ab088039 - Provider product page
Provider
Aladdin Scientific
Product name
ALDH1A1 Mouse mAb
Antibody type
Monoclonal
Description
Application:WB: 1/500 - 1/2000. Predicted molecular weight: 55 kDa. IHC: 1/200 - 1/1000 ELISA: 1/10000Protein FunctionBinds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid.ALDH1A1 is an aldehyde dehydrogenase able to oxidize a wide variety of aliphatic aldehydes (retinaldehyde, acetaldehyde, etc.) to the corresponding carboxylic acids (retinoic acid, acetic acid, etc.). ALDH1A1 (also known as RALDH1, ALDH1, or AHD2) is highly expressed in the dorsal retina, ventral midbrain (dopaminergic neurons), and hematopoietic stem cells. ALDH1A1 is involved in retinoic acid (RA) synthesis during vertebrate embryogenesis. ALDH1A1 is first detected at E9.0-E10.5 in cranial tissues (ventral mesencephalon, dorsal retina, thymic primordia, optic vesicles) and in the mesonephros. ALDH1A1 is also of interest in Parkinson's Disease (PD) being expressed in the the A9 dopaminergic (DA) neuronal group projecting to the dorsal striatum; this is the most vulnerable site in PD (Chung et al, 2005). ALDH1A1 protein is a known mesencephalic dopaminergic marker. ALDH1A1 is a cytosolic enzyme that preferentially oxidizes retinaldehyde to retinoic acid .ALDH1A1 is expressed in the epithelium of many organs, including brain, liver, testis, eye lens and cornea .ALDH1A1 is highly expressed in brain dopaminergic neurons, where it produces the retinoic acid required for their differentiation and development .The retinoic acid produced by ALDH1A1 is also important for the differentiation of hematopoietic stem cells.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
AA 7-128
Isotype
IgG
Antibody clone number
5A11
Vial size
100_l,10_l,1ml,50_l
Concentration
1 mg/ml
Storage
Shipped at 4¡C. Store at +4¡C short term (1-2 weeks). Store at -20¡C long term.
ALDH1A1 protein structure - Ab088039 shown in red.