Antibody data
- Antibody Data
- Antigen structure
- References [16]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 14609-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- SMPD1,ASM antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SMPD1,ASM antibody (Cat. #14609-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents.
Targeting lysosomal HSP70 induces acid sphingomyelinase-mediated disturbance of lipid metabolism and leads to cell death in T cell malignancies.
Novel Isolation Method Reveals Sex-Specific Composition and Neurotoxicity of Small Extracellular Vesicles in a Mouse Model of Alzheimer's Disease.
Acid sphingomyelinase expression is associated with survival in resectable pancreatic ductal adenocarcinoma.
Polyphyllin D punctures hypertrophic lysosomes to reverse drug resistance of hepatocellular carcinoma by targeting acid sphingomyelinase.
Proteome-Wide Analysis Reveals TFEB Targets for Establishment of a Prognostic Signature to Predict Clinical Outcomes of Colorectal Cancer.
Inhibition of acid sphingomyelinase reduces reactive astrocyte secretion of mitotoxic extracellular vesicles and improves Alzheimer's disease pathology in the 5xFAD mouse.
Involvement of Huanglian Jiedu Decoction on Microglia with Abnormal Sphingolipid Metabolism in Alzheimer's Disease.
Exercise Promotes Pro-Apoptotic Ceramide Signaling in a Mouse Melanoma Model.
Ablation of sphingosine kinase 2 suppresses fatty liver-associated hepatocellular carcinoma via downregulation of ceramide transfer protein.
Lycium barbarum polysaccharides attenuates high glucose-induced diabetic retinal angiogenesis by rescuing the expression of miR-15a-5p in RF/6A cells.
Acid sphingomyelinase downregulation alleviates vascular endothelial leptin resistance in rats.
Comparative lipidomics of 5-Fluorouracil-sensitive and -resistant colorectal cancer cells reveals altered sphingomyelin and ceramide controlled by acid sphingomyelinase (SMPD1).
Interrelations of Sphingolipid and Lysophosphatidate Signaling with Immune System in Ovarian Cancer.
The β(2) Integrin Mac-1 Induces Protective LC3-Associated Phagocytosis of Listeria monocytogenes.
Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis.
He Y, Kaya I, Shariatgorji R, Lundkvist J, Wahlberg LU, Nilsson A, Mamula D, Kehr J, Zareba-Paslawska J, Biverstål H, Chergui K, Zhang X, Andren PE, Svenningsson P
Nature communications 2023 Sep 19;14(1):5804
Nature communications 2023 Sep 19;14(1):5804
Targeting lysosomal HSP70 induces acid sphingomyelinase-mediated disturbance of lipid metabolism and leads to cell death in T cell malignancies.
Qing Y, Guo Y, Zhao Q, Hu P, Li H, Yu X, Zhu M, Wang H, Wang Z, Xu J, Guo Q, Hui H
Clinical and translational medicine 2023 Mar;13(3):e1229
Clinical and translational medicine 2023 Mar;13(3):e1229
Novel Isolation Method Reveals Sex-Specific Composition and Neurotoxicity of Small Extracellular Vesicles in a Mouse Model of Alzheimer's Disease.
Elsherbini A, Zhu Z, Quadri Z, Crivelli SM, Ren X, Vekaria HJ, Tripathi P, Zhang L, Zhi W, Bieberich E
Cells 2023 Jun 14;12(12)
Cells 2023 Jun 14;12(12)
Acid sphingomyelinase expression is associated with survival in resectable pancreatic ductal adenocarcinoma.
Wilson GC, Patel SH, Wang J, Xu K, Turner KM, Becker KA, Carpinteiro A, Szabo I, Ahmad SA, Gulbins E
Journal of molecular medicine (Berlin, Germany) 2023 Jul;101(7):891-903
Journal of molecular medicine (Berlin, Germany) 2023 Jul;101(7):891-903
Polyphyllin D punctures hypertrophic lysosomes to reverse drug resistance of hepatocellular carcinoma by targeting acid sphingomyelinase.
Wang Y, Chen YY, Gao GB, Zheng YH, Yu NN, Ouyang L, Gao X, Li N, Wen SY, Huang S, Zhao Q, Liu L, Cao M, Zhang S, Zhang J, He QY
Molecular therapy : the journal of the American Society of Gene Therapy 2023 Jul 5;31(7):2169-2187
Molecular therapy : the journal of the American Society of Gene Therapy 2023 Jul 5;31(7):2169-2187
Proteome-Wide Analysis Reveals TFEB Targets for Establishment of a Prognostic Signature to Predict Clinical Outcomes of Colorectal Cancer.
Huang Z, Zhu S, Han Z, Li C, Liang J, Wang Y, Zhang S, Zhang J
Cancers 2023 Jan 25;15(3)
Cancers 2023 Jan 25;15(3)
Inhibition of acid sphingomyelinase reduces reactive astrocyte secretion of mitotoxic extracellular vesicles and improves Alzheimer's disease pathology in the 5xFAD mouse.
Crivelli SM, Quadri Z, Vekaria HJ, Zhu Z, Tripathi P, Elsherbini A, Zhang L, Sullivan PG, Bieberich E
Acta neuropathologica communications 2023 Aug 21;11(1):135
Acta neuropathologica communications 2023 Aug 21;11(1):135
Involvement of Huanglian Jiedu Decoction on Microglia with Abnormal Sphingolipid Metabolism in Alzheimer's Disease.
Qi YY, Heng X, Yao ZY, Qu SY, Ge PY, Zhao X, Ni SJ, Guo R, Yang NY, Zhang QC, Zhu HX
Drug design, development and therapy 2022;16:931-950
Drug design, development and therapy 2022;16:931-950
Exercise Promotes Pro-Apoptotic Ceramide Signaling in a Mouse Melanoma Model.
Lee J, Savage H, Maegawa S, Ballarò R, Pareek S, Guerrouahen BS, Gopalakrishnan V, Schadler K
Cancers 2022 Sep 2;14(17)
Cancers 2022 Sep 2;14(17)
Ablation of sphingosine kinase 2 suppresses fatty liver-associated hepatocellular carcinoma via downregulation of ceramide transfer protein.
Liu XT, Chung LH, Liu D, Chen J, Huang Y, Teo JD, Han XD, Zhao Y, Guan FHX, Tran C, Lee JY, Couttas TA, Liu K, McCaughan GW, Gorrell MD, Don AS, Zhang S, Qi Y
Oncogenesis 2022 Nov 4;11(1):67
Oncogenesis 2022 Nov 4;11(1):67
Lycium barbarum polysaccharides attenuates high glucose-induced diabetic retinal angiogenesis by rescuing the expression of miR-15a-5p in RF/6A cells.
Zhu Y, Zhao Q, Jiang Y
Journal of ethnopharmacology 2022 Jan 30;283:114652
Journal of ethnopharmacology 2022 Jan 30;283:114652
Acid sphingomyelinase downregulation alleviates vascular endothelial leptin resistance in rats.
Cai BB, Lu YN, Xu M
Acta pharmacologica Sinica 2020 May;41(5):650-660
Acta pharmacologica Sinica 2020 May;41(5):650-660
Comparative lipidomics of 5-Fluorouracil-sensitive and -resistant colorectal cancer cells reveals altered sphingomyelin and ceramide controlled by acid sphingomyelinase (SMPD1).
Jung JH, Taniguchi K, Lee HM, Lee MY, Bandu R, Komura K, Lee KY, Akao Y, Kim KP
Scientific reports 2020 Apr 9;10(1):6124
Scientific reports 2020 Apr 9;10(1):6124
Interrelations of Sphingolipid and Lysophosphatidate Signaling with Immune System in Ovarian Cancer.
Meshcheryakova A, Svoboda M, Jaritz M, Mungenast F, Salzmann M, Pils D, Cacsire Castillo-Tong D, Hager G, Wolf A, Braicu EI, Sehouli J, Lambrechts S, Vergote I, Mahner S, Birner P, Zimmermann P, Brindley DN, Heinze G, Zeillinger R, Mechtcheriakova D
Computational and structural biotechnology journal 2019;17:537-560
Computational and structural biotechnology journal 2019;17:537-560
The β(2) Integrin Mac-1 Induces Protective LC3-Associated Phagocytosis of Listeria monocytogenes.
Gluschko A, Herb M, Wiegmann K, Krut O, Neiss WF, Utermöhlen O, Krönke M, Schramm M
Cell host & microbe 2018 Mar 14;23(3):324-337.e5
Cell host & microbe 2018 Mar 14;23(3):324-337.e5
Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis.
Tang YC, Yuwen H, Wang K, Bruno PM, Bullock K, Deik A, Santaguida S, Trakala M, Pfau SJ, Zhong N, Huang T, Wang L, Clish CB, Hemann MT, Amon A
Cancer research 2017 Oct 1;77(19):5272-5286
Cancer research 2017 Oct 1;77(19):5272-5286
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SMPD1,ASM antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SMPD1,ASM. This antibody recognizes human,mouse,rat antigen. The SMPD1,ASM antibody has been validated for the following applications: ELISA, WB analysis.