FNab10359

antibody from FineTest Biotech

Targeting: APTX AOA, AOA1, AXA1, EAOH, EOAHA, FLJ20157

Western blot

ELISA

Immunohistochemistry

Antibody data

Submit

Validation data

Product number: FNab10359 - Provider product page
Provider: FineTest Biotech
Product name: APTX antibody
Antibody type: Polyclonal
Antigen: Recombinant protein fragment
Description: APTX, also named as Aprataxin, is a nuclear protein, present in both the nucleoplasm and the nucleolus, which is a member of the histidine triad (HIT) superfamily. APTX is involved in DNA single-strand break repair, mediating protein-protein interactions with molecules responding to DNA damage. APTX contains three conserved domains: an N-terminal forkhead-associated (FHA) domain which mediates protein-protein interactions, a HIT domain that is similar to Hint, and a C-terminal zinc finger domain. Loss of function mutations in APTX, the gene encoding for Aprataxin, destabilize the Aprataxin protein and result in a rare neurological disorder known as ataxia-oculomotor apraxia, characterized by abnormal movements of the head and eyes.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Antigen sequence: aprataxin
Epitope: IgG
Isotype: IgG
Vial size: 100¦Ìg
Concentration: Immunogen affinity purified
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months (Avoid repeated freeze / thaw cycles.)
Handling: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months (Avoid repeated freeze / thaw cycles.)

APTX protein structure - FNab10359 shown in red.