Ab129838

antibody from Aladdin Scientific Corporation

Targeting: BIRC5 API4, EPR-1, survivin

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

Ab129838

Provider

Aladdin Scientific Corporation

Product name

Survivin Mouse mAb

Antibody type

Monoclonal

Description

Mouse anti Human Survivin Antibody, Monoclonal (C3), could be used for WB, IHC and so on. Application WB: 0.01-2 µg/mL IHC: 5-30 μg/mL Protein Function Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May play a role in neoplasia. May counteract a default induction of apoptosis in G2/M phase. Inhibitor of caspase-3 and caspase-7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Antigen sequence

AA 1-142


Antibody clone number

C3

Vial size

100μl,10μl,1ml,20μl,50μl

Concentration

Lot by Lot

Storage

Store at 4℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.