10-1040

antibody from ABEOMICS Inc.
Targeting: CASP1 ICE, IL1BC
Provider product page for 10-1040

Antibody data

Product number
10-1040 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-Caspase-1 Antibody
Antibody type
Monoclonal
Description
Caspase-1 is a member of the cysteine-aspartic acid protease (caspase) family, which acts as a proinflammatory caspase whose catalytic activity is tightly regulated by signal-dependent autoactivation within inflammasomes. Caspase-1 is produced as a zymogen that is cleaved into 20 kDa (p20) and 10 kDa (p10) subunits that become part of the active enzyme. Active caspase-1 contains two heterodimers of p20 and p10. It interacts with another CARD domain containing protein called PYCARD (or ASC) and is involved in inflammasome formation and activation of inflammatory processes. Inflammasome-dependent caspase-1 activity results in a highly inflammatory form of cell death known as pyroptosis, primarily described in myeloid cells infected with intracellular bacterial pathogens. caspase-1 is implicated in promoting CD4 T-cell death and inflammation by HIV, two signature events that fuel HIV disease progression to AIDS.
Reactivity
Human, Mouse
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
A partial length recombinant Caspas
e-1 protein (amino acids 203-400) w
as used as the immunogen for this a
ntibody.
Isotype
IgG
Antibody clone number
ABM1B93
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
CASP1 protein structure - 10-1040 shown in red.