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- References [19]
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- Product number
- NBP1-45433 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NBP1-45433, RRID:AB_10008900
- Product name
- Rabbit Polyclonal Caspase-1 Antibody
- Antibody type
- Polyclonal
- Description
- Affinity purified. The antibody recognizes the 45 kDa procaspase-1 and the 20 kDa cleaved product.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 mg
- Concentration
- 0.5 mg/ml
- Storage
- Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Submitted references Ezetimibe Attenuates Oxidative Stress and Neuroinflammation via the AMPK/Nrf2/TXNIP Pathway after MCAO in Rats.
Platelet activating factor receptor acts to limit colitis-induced liver inflammation.
AIM2 inflammasome contributes to brain injury and chronic post-stroke cognitive impairment in mice.
Celastrol augments sensitivity of NLRP3 to CP-456773 by modulating HSP-90 and inducing autophagy in dextran sodium sulphate-induced colitis in rats.
Exendin-4 Protects against Hyperglycemia-Induced Cardiomyocyte Pyroptosis via the AMPK-TXNIP Pathway.
Novel role of NLRP3-inflammasome in regulation of lipogenesis in fasting-induced hepatic steatosis.
Involvement of NLRP3 and NLRC4 Inflammasome in Uropathogenic E. coli Mediated Urinary Tract Infections.
Platelet activating factor receptor regulates colitis-induced pulmonary inflammation through the NLRP3 inflammasome.
Preventive effect of bergenin against the development of TNBS-induced acute colitis in rats is associated with inflammatory mediators inhibition and NLRP3/ASC inflammasome signaling pathways.
Involvement of purinergic 2X4 receptor in glycoprotein 120-induced pyroptosis in dorsal root ganglia.
Dihydromyricetin inhibits NLRP3 inflammasome-dependent pyroptosis by activating the Nrf2 signaling pathway in vascular endothelial cells.
Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock.
Dihydrolipoic Acid Inhibits Lysosomal Rupture and NLRP3 Through Lysosome-Associated Membrane Protein-1/Calcium/Calmodulin-Dependent Protein Kinase II/TAK1 Pathways After Subarachnoid Hemorrhage in Rat.
Wnt5a contributes to dectin-1 and LOX-1 induced host inflammatory response signature in Aspergillus fumigatus keratitis.
Cathepsin B regulates non-canonical NLRP3 inflammasome pathway by modulating activation of caspase-11 in Kupffer cells.
Trimethylamine-N-Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3-SOD2-mtROS Signaling Pathway.
Low-level light emitting diode (LED) therapy suppresses inflammasome-mediated brain damage in experimental ischemic stroke.
Omega-3 fatty acids regulate NLRP3 inflammasome activation and prevent behavior deficits after traumatic brain injury.
Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death.
Yu J, Wang WN, Matei N, Li X, Pang JW, Mo J, Chen SP, Tang JP, Yan M, Zhang JH
Oxidative medicine and cellular longevity 2020;2020:4717258
Oxidative medicine and cellular longevity 2020;2020:4717258
Platelet activating factor receptor acts to limit colitis-induced liver inflammation.
Liu G, Baird AW, Parsons MJ, Fan K, Skerrett-Byrne DA, Nair PM, Makanyengo S, Chen J, Neal R, Goggins BJ, Tay H, Mathe A, Soh WS, Minahan K, Hansbro PM, Nixon B, McCaughan GW, Holtmann G, Colgan SP, Keely S
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jun;34(6):7718-7732
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jun;34(6):7718-7732
AIM2 inflammasome contributes to brain injury and chronic post-stroke cognitive impairment in mice.
Kim H, Seo JS, Lee SY, Ha KT, Choi BT, Shin YI, Ju Yun Y, Shin HK
Brain, behavior, and immunity 2020 Jul;87:765-776
Brain, behavior, and immunity 2020 Jul;87:765-776
Celastrol augments sensitivity of NLRP3 to CP-456773 by modulating HSP-90 and inducing autophagy in dextran sodium sulphate-induced colitis in rats.
Saber S, Abd El-Kader EM, Sharaf H, El-Shamy R, El-Saeed B, Mostafa A, Ezzat D, Shata A
Toxicology and applied pharmacology 2020 Aug 1;400:115075
Toxicology and applied pharmacology 2020 Aug 1;400:115075
Exendin-4 Protects against Hyperglycemia-Induced Cardiomyocyte Pyroptosis via the AMPK-TXNIP Pathway.
Wei H, Bu R, Yang Q, Jia J, Li T, Wang Q, Chen Y
Journal of diabetes research 2019;2019:8905917
Journal of diabetes research 2019;2019:8905917
Novel role of NLRP3-inflammasome in regulation of lipogenesis in fasting-induced hepatic steatosis.
Liu B, Mao X, Huang D, Li F, Dong N
Diabetes, metabolic syndrome and obesity : targets and therapy 2019;12:801-811
Diabetes, metabolic syndrome and obesity : targets and therapy 2019;12:801-811
Involvement of NLRP3 and NLRC4 Inflammasome in Uropathogenic E. coli Mediated Urinary Tract Infections.
Verma V, Gupta S, Kumar P, Yadav S, Dhanda RS, Gaind R, Arora R, Frimodt-Møller N, Yadav M
Frontiers in microbiology 2019;10:2020
Frontiers in microbiology 2019;10:2020
Platelet activating factor receptor regulates colitis-induced pulmonary inflammation through the NLRP3 inflammasome.
Liu G, Mateer SW, Hsu A, Goggins BJ, Tay H, Mathe A, Fan K, Neal R, Bruce J, Burns G, Minahan K, Maltby S, Fricker M, Foster PS, Wark PAB, Hansbro PM, Keely S
Mucosal immunology 2019 Jul;12(4):862-873
Mucosal immunology 2019 Jul;12(4):862-873
Preventive effect of bergenin against the development of TNBS-induced acute colitis in rats is associated with inflammatory mediators inhibition and NLRP3/ASC inflammasome signaling pathways.
Lopes de Oliveira GA, Alarcón de la Lastra C, Rosillo MÁ, Castejon Martinez ML, Sánchez-Hidalgo M, Rolim Medeiros JV, Villegas I
Chemico-biological interactions 2019 Jan 5;297:25-33
Chemico-biological interactions 2019 Jan 5;297:25-33
Involvement of purinergic 2X4 receptor in glycoprotein 120-induced pyroptosis in dorsal root ganglia.
Zhao S, Zhou Y, Fan Y, Gong Y, Yang J, Yang R, Li L, Zou L, Xu X, Li G, Liu S, Zhang C, Li G, Liang S
Journal of neurochemistry 2019 Dec;151(5):584-594
Journal of neurochemistry 2019 Dec;151(5):584-594
Dihydromyricetin inhibits NLRP3 inflammasome-dependent pyroptosis by activating the Nrf2 signaling pathway in vascular endothelial cells.
Hu Q, Zhang T, Yi L, Zhou X, Mi M
BioFactors (Oxford, England) 2018 Mar;44(2):123-136
BioFactors (Oxford, England) 2018 Mar;44(2):123-136
Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock.
Mandal P, Feng Y, Lyons JD, Berger SB, Otani S, DeLaney A, Tharp GK, Maner-Smith K, Burd EM, Schaeffer M, Hoffman S, Capriotti C, Roback L, Young CB, Liang Z, Ortlund EA, DiPaolo NC, Bosinger S, Bertin J, Gough PJ, Brodsky IE, Coopersmith CM, Shayakhmetov DM, Mocarski ES
Immunity 2018 Jul 17;49(1):42-55.e6
Immunity 2018 Jul 17;49(1):42-55.e6
Dihydrolipoic Acid Inhibits Lysosomal Rupture and NLRP3 Through Lysosome-Associated Membrane Protein-1/Calcium/Calmodulin-Dependent Protein Kinase II/TAK1 Pathways After Subarachnoid Hemorrhage in Rat.
Zhou K, Enkhjargal B, Xie Z, Sun C, Wu L, Malaguit J, Chen S, Tang J, Zhang J, Zhang JH
Stroke 2018 Jan;49(1):175-183
Stroke 2018 Jan;49(1):175-183
Wnt5a contributes to dectin-1 and LOX-1 induced host inflammatory response signature in Aspergillus fumigatus keratitis.
Che C, Li C, Lin J, Zhang J, Jiang N, Yuan K, Zhao G
Cellular signalling 2018 Dec;52:103-111
Cellular signalling 2018 Dec;52:103-111
Cathepsin B regulates non-canonical NLRP3 inflammasome pathway by modulating activation of caspase-11 in Kupffer cells.
Chen N, Ou Z, Zhang W, Zhu X, Li P, Gong J
Cell proliferation 2018 Dec;51(6):e12487
Cell proliferation 2018 Dec;51(6):e12487
Trimethylamine-N-Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3-SOD2-mtROS Signaling Pathway.
Chen ML, Zhu XH, Ran L, Lang HD, Yi L, Mi MT
Journal of the American Heart Association 2017 Sep 4;6(9)
Journal of the American Heart Association 2017 Sep 4;6(9)
Low-level light emitting diode (LED) therapy suppresses inflammasome-mediated brain damage in experimental ischemic stroke.
Lee HI, Lee SW, Kim NG, Park KJ, Choi BT, Shin YI, Shin HK
Journal of biophotonics 2017 Nov;10(11):1502-1513
Journal of biophotonics 2017 Nov;10(11):1502-1513
Omega-3 fatty acids regulate NLRP3 inflammasome activation and prevent behavior deficits after traumatic brain injury.
Lin C, Chao H, Li Z, Xu X, Liu Y, Bao Z, Hou L, Liu Y, Wang X, You Y, Liu N, Ji J
Experimental neurology 2017 Apr;290:115-122
Experimental neurology 2017 Apr;290:115-122
Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death.
Draganov D, Gopalakrishna-Pillai S, Chen YR, Zuckerman N, Moeller S, Wang C, Ann D, Lee PP
Scientific reports 2015 Nov 10;5:16222
Scientific reports 2015 Nov 10;5:16222
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: Caspase-1 Antibody [NBP1-45433] - Analysis of Caspase-1 expression in Rat liver tissue lysate.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: Caspase-1 Antibody [NBP1-45433] - Exendin-4 inhibits diabetic cardiomyocyte pyroptosis: (f) Western blot of pyroptotic proteins. The primary cardiomyocytes were incubated in the absence (CON) or presence of 40mM glucose (HG) in combination with Exendin-4 (25nM) (HG+EXE). Image collected and cropped by CiteAb from the following publication (ncbi.nlm.nih.gov/pmc/articles/PMC6925927/), licensed under a CC-BY licence.
