abx000562

antibody from Abbexa

Targeting: PBX1

Western blot (Recommended by provider)

Antibody Data

Product number

abx000562

Provider

Abbexa

Product name

Pre-B-Cell Leukemia Transcription Factor 1 (PBX1) Antibody

Antibody type

Polyclonal

Description

PBX1 Antibody is a Rabbit Polyclonal antibody against PBX1. This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Concentration

> 1 mg/ml

Storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.