BS7762

antibody from Bioworld Technology, Inc
Targeting: ASH2L ASH2, ASH2L1, ASH2L2, Bre2
Provider product page for BS7762
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS7762 - Provider product page
Provider
Bioworld Technology, Inc
Product name
ASH2L polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human ASH2L.
Description
The human ASH2L gene encodes a 628 amino acid protein known as ASH2L1, or isoform 1, which contains a nuclear localization signal and PHD finger motif, suggesting that the gene product functions as a transcription regulator. Alternative splicing results in a shorter isoform 2, designated ASH2L2, which is missing the first 94 amino acid residues found in ASH2L1. Human ASH2L proteins are 60% homologous to Drosophila ash2, which positively regulates expression of certain genes in early development, and contain similar, but not identical, domains, including a zinc finger motif. ASH2L is highly expressed in fetal liver, testis and leukemia cell lines with erythroid and megakaryocytic potential, such as K562, Hel and Dami. Differentiation inducers (e.g. phorbol ester and hemin) cause different expression patterns in these cells lines, suggesting that ASH2L plays a role in hematopoiesis and is associated with particular types of leukemia.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
ASH2L protein structure - BS7762 shown in red.