Antibody data
- Antibody Data
- Antigen structure
- References [53]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 13763-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13763-1-AP, RRID:AB_2162854
- Product name
- PFKFB3-Specific antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PFKFB3-Specific antibody (Cat. #13763-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Metformin Corrects Glucose Metabolism Reprogramming and NLRP3 Inflammasome-Induced Pyroptosis via Inhibiting the TLR4/NF-κB/PFKFB3 Signaling in Trophoblasts: Implication for a Potential Therapy of Preeclampsia.
Dual Inhibition of Endoplasmic Reticulum Stress and Oxidation Stress Manipulates the Polarization of Macrophages under Hypoxia to Sensitize Immunotherapy.
Newcastle disease virus degrades SIRT3 via PINK1-PRKN-dependent mitophagy to reprogram energy metabolism in infected cells.
Circular RNA circ-FoxO3 attenuates blood-brain barrier damage by inducing autophagy during ischemia/reperfusion.
Sex differences in metabolic pathways are regulated by Pfkfb3 and Pdk4 expression in rodent muscle.
PFKFB3 regulates lipopolysaccharide-induced excessive inflammation and cellular dysfunction in HTR-8/Svneo cells: Implications for the role of PFKFB3 in preeclampsia.
MALAT1 sponges miR-26a and miR-26b to regulate endothelial cell angiogenesis via PFKFB3-driven glycolysis in early-onset preeclampsia.
PFKFB3 Inhibition Sensitizes DNA Crosslinking Chemotherapies by Suppressing Fanconi Anemia Repair.
NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis.
Prkaa1 Metabolically Regulates Monocyte/Macrophage Recruitment and Viability in Diet-Induced Murine Metabolic Disorders.
Fenofibrate-induced mitochondrial dysfunction and metabolic reprogramming reversal: the anti-tumor effects in gastric carcinoma cells mediated by the PPAR pathway.
Inhibition of eNOS by L-NAME resulting in rat hind limb developmental defects through PFKFB3 mediated angiogenetic pathway.
PFKFB2 regulates glycolysis and proliferation in pancreatic cancer cells.
Metabolic adaptations in spontaneously immortalized PGC-1α knock-out mouse embryonic fibroblasts increase their oncogenic potential.
Tissue-Resident Alveolar Macrophages Do Not Rely on Glycolysis for LPS-induced Inflammation.
Inhibition of PFKFB3 suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss.
TAB1 regulates glycolysis and activation of macrophages in diabetic nephropathy.
Zhx2 Accelerates Sepsis by Promoting Macrophage Glycolysis via Pfkfb3.
Deoxyelephantopin suppresses hepatic stellate cells activation associated with inhibition of aerobic glycolysis via hedgehog pathway.
PFKFB3 in Smooth Muscle Promotes Vascular Remodeling in Pulmonary Arterial Hypertension.
PFKFB3 Inhibition Attenuates Oxaliplatin-Induced Autophagy and Enhances Its Cytotoxicity in Colon Cancer Cells.
Monocarboxylate transporter 1 promotes classical microglial activation and pro-inflammatory effect via 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3.
Phostine 3.1a as a pharmacological compound with antiangiogenic properties against diseases with excess vascularization.
Andrographolide attenuates imbalance of gastric vascular homeostasis induced by ethanol through glycolysis pathway.
PFKFB3/HIF-1α feedback loop modulates sorafenib resistance in hepatocellular carcinoma cells.
Increased 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 activity in response to EGFR signaling contributes to non-small cell lung cancer cell survival.
CircACC1 Regulates Assembly and Activation of AMPK Complex under Metabolic Stress.
The Glycolytic Enzyme PFKFB3 Controls TNF-α-Induced Endothelial Proinflammatory Responses.
PFKFB3 promotes endotoxemia-induced myocardial dysfunction through inflammatory signaling and apoptotic induction.
Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination.
Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis.
Ginkgetin induces cell death in breast cancer cells via downregulation of the estrogen receptor.
Exercise-Induced Changes in Glucose Metabolism Promote Physiological Cardiac Growth.
FGF-dependent metabolic control of vascular development.
USP9X regulates centrosome duplication and promotes breast carcinogenesis.
6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase-3 is required for transforming growth factor β1-enhanced invasion of Panc1 cells in vitro.
PFKFB3, a Direct Target of p63, Is Required for Proliferation and Inhibits Differentiation in Epidermal Keratinocytes.
PFKFB3-Driven Macrophage Glycolytic Metabolism Is a Crucial Component of Innate Antiviral Defense.
Inhibition of 6-phosphofructo-2-kinase (PFKFB3) suppresses glucose metabolism and the growth of HER2+ breast cancer.
p53 coordinates DNA repair with nucleotide synthesis by suppressing PFKFB3 expression and promoting the pentose phosphate pathway.
Type 2 Diabetes Dysregulates Glucose Metabolism in Cardiac Progenitor Cells.
Glucose and Palmitate Differentially Regulate PFKFB3/iPFK2 and Inflammatory Responses in Mouse Intestinal Epithelial Cells.
IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3.
Metabolic control of the cell cycle.
The monocarboxylate transporter 4 is required for glycolytic reprogramming and inflammatory response in macrophages.
Glycolytic Reprogramming in Myofibroblast Differentiation and Lung Fibrosis.
miR-26b inhibits proliferation, migration, invasion and apoptosis induction via the downregulation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 driven glycolysis in osteosarcoma cells.
Estradiol stimulates glucose metabolism via 6-phosphofructo-2-kinase (PFKFB3).
Endothelial PFKFB3 plays a critical role in angiogenesis.
6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27.
Inhibition of 6-phosphofructo-2-kinase (PFKFB3) induces autophagy as a survival mechanism.
Role of PFKFB3-driven glycolysis in vessel sprouting.
Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation.
Zhang Y, Liu W, Zhong Y, Li Q, Wu M, Yang L, Liu X, Zou L
Oxidative medicine and cellular longevity 2021;2021:1806344
Oxidative medicine and cellular longevity 2021;2021:1806344
Dual Inhibition of Endoplasmic Reticulum Stress and Oxidation Stress Manipulates the Polarization of Macrophages under Hypoxia to Sensitize Immunotherapy.
Jiang M, Li X, Zhang J, Lu Y, Shi Y, Zhu C, Liu Y, Qin B, Luo Z, Du Y, Luo L, Peng L, You J
ACS nano 2021 Sep 28;15(9):14522-14534
ACS nano 2021 Sep 28;15(9):14522-14534
Newcastle disease virus degrades SIRT3 via PINK1-PRKN-dependent mitophagy to reprogram energy metabolism in infected cells.
Gong Y, Tang N, Liu P, Sun Y, Lu S, Liu W, Tan L, Song C, Qiu X, Liao Y, Yu S, Liu X, Lin SH, Ding C
Autophagy 2021 Oct 31;:1-19
Autophagy 2021 Oct 31;:1-19
Circular RNA circ-FoxO3 attenuates blood-brain barrier damage by inducing autophagy during ischemia/reperfusion.
Yang Z, Huang C, Wen X, Liu W, Huang X, Li Y, Zang J, Weng Z, Lu D, Tsang CK, Li K, Xu A
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Nov 8;
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Nov 8;
Sex differences in metabolic pathways are regulated by Pfkfb3 and Pdk4 expression in rodent muscle.
Christianto A, Baba T, Takahashi F, Inui K, Inoue M, Suyama M, Ono Y, Ohkawa Y, Morohashi KI
Communications biology 2021 Nov 4;4(1):1264
Communications biology 2021 Nov 4;4(1):1264
PFKFB3 regulates lipopolysaccharide-induced excessive inflammation and cellular dysfunction in HTR-8/Svneo cells: Implications for the role of PFKFB3 in preeclampsia.
Zhang Y, Liu W, Wu M, Li Q, Liu Y, Yang L, Chen Y, Zhong Y, Liu X, Zou L
Placenta 2021 Mar;106:67-78
Placenta 2021 Mar;106:67-78
MALAT1 sponges miR-26a and miR-26b to regulate endothelial cell angiogenesis via PFKFB3-driven glycolysis in early-onset preeclampsia.
Li Q, Liu X, Liu W, Zhang Y, Wu M, Chen Z, Zhao Y, Zou L
Molecular therapy. Nucleic acids 2021 Mar 5;23:897-907
Molecular therapy. Nucleic acids 2021 Mar 5;23:897-907
PFKFB3 Inhibition Sensitizes DNA Crosslinking Chemotherapies by Suppressing Fanconi Anemia Repair.
Ninou AH, Lehto J, Chioureas D, Stigsdotter H, Schelzig K, Åkerlund E, Gudoityte G, Joneborg U, Carlson J, Jonkers J, Seashore-Ludlow B, Gustafsson NMS
Cancers 2021 Jul 18;13(14)
Cancers 2021 Jul 18;13(14)
NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis.
Park MK, Zhang L, Min KW, Cho JH, Yeh CC, Moon H, Hormaechea-Agulla D, Mun H, Ko S, Lee JW, Jathar S, Smith AS, Yao Y, Giang NT, Vu HH, Yan VC, Bridges MC, Kourtidis A, Muller F, Chang JH, Song SJ, Nakagawa S, Hirose T, Yoon JH, Song MS
Cell metabolism 2021 Dec 7;33(12):2380-2397.e9
Cell metabolism 2021 Dec 7;33(12):2380-2397.e9
Prkaa1 Metabolically Regulates Monocyte/Macrophage Recruitment and Viability in Diet-Induced Murine Metabolic Disorders.
Yang Q, Ma Q, Xu J, Liu Z, Zou J, Shen J, Zhou Y, Da Q, Mao X, Lu S, Fulton DJ, Weintraub NL, Bagi Z, Hong M, Huo Y
Frontiers in cell and developmental biology 2020;8:611354
Frontiers in cell and developmental biology 2020;8:611354
Fenofibrate-induced mitochondrial dysfunction and metabolic reprogramming reversal: the anti-tumor effects in gastric carcinoma cells mediated by the PPAR pathway.
Chen L, Peng J, Wang Y, Jiang H, Wang W, Dai J, Tang M, Wei Y, Kuang H, Xu G, Xu H, Zhou F
American journal of translational research 2020;12(2):428-446
American journal of translational research 2020;12(2):428-446
Inhibition of eNOS by L-NAME resulting in rat hind limb developmental defects through PFKFB3 mediated angiogenetic pathway.
Wu Z, Yao H, Xu H, Wang Y, Hu W, Lou G, Zhang L, Huang C, Jiang C, Zhou S, Shi Y, Chen X, Yang L, Xu Y, Wang Y
Scientific reports 2020 Oct 7;10(1):16754
Scientific reports 2020 Oct 7;10(1):16754
PFKFB2 regulates glycolysis and proliferation in pancreatic cancer cells.
Ozcan SC, Sarioglu A, Altunok TH, Akkoc A, Guzel S, Guler S, Imbert-Fernandez Y, Muchut RJ, Iglesias AA, Gurpinar Y, Clem AL, Chesney JA, Yalcin A
Molecular and cellular biochemistry 2020 Jul;470(1-2):115-129
Molecular and cellular biochemistry 2020 Jul;470(1-2):115-129
Metabolic adaptations in spontaneously immortalized PGC-1α knock-out mouse embryonic fibroblasts increase their oncogenic potential.
Prieto I, Alarcón CR, García-Gómez R, Berdún R, Urgel T, Portero M, Pamplona R, Martínez-Ruiz A, Ruiz-Sanz JI, Ruiz-Larrea MB, Jove M, Cerdán S, Monsalve M
Redox biology 2020 Jan;29:101396
Redox biology 2020 Jan;29:101396
Tissue-Resident Alveolar Macrophages Do Not Rely on Glycolysis for LPS-induced Inflammation.
Woods PS, Kimmig LM, Meliton AY, Sun KA, Tian Y, O'Leary EM, Gökalp GA, Hamanaka RB, Mutlu GM
American journal of respiratory cell and molecular biology 2020 Feb;62(2):243-255
American journal of respiratory cell and molecular biology 2020 Feb;62(2):243-255
Inhibition of PFKFB3 suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss.
Wang J, Guan H, Liu H, Lei Z, Kang H, Guo Q, Dong Y, Liu H, Sun Y, Fang Z, Li F
Journal of cellular and molecular medicine 2020 Feb;24(3):2294-2307
Journal of cellular and molecular medicine 2020 Feb;24(3):2294-2307
TAB1 regulates glycolysis and activation of macrophages in diabetic nephropathy.
Zeng H, Qi X, Xu X, Wu Y
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2020 Dec;69(12):1215-1234
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2020 Dec;69(12):1215-1234
Zhx2 Accelerates Sepsis by Promoting Macrophage Glycolysis via Pfkfb3.
Wang Z, Kong L, Tan S, Zhang Y, Song X, Wang T, Lin Q, Wu Z, Xiang P, Li C, Gao L, Liang X, Ma C
Journal of immunology (Baltimore, Md. : 1950) 2020 Apr 15;204(8):2232-2241
Journal of immunology (Baltimore, Md. : 1950) 2020 Apr 15;204(8):2232-2241
Deoxyelephantopin suppresses hepatic stellate cells activation associated with inhibition of aerobic glycolysis via hedgehog pathway.
Gao W, Sun J, Wang F, Lu Y, Wen C, Bian Q, Wu H
Biochemical and biophysical research communications 2019 Sep 3;516(4):1222-1228
Biochemical and biophysical research communications 2019 Sep 3;516(4):1222-1228
PFKFB3 in Smooth Muscle Promotes Vascular Remodeling in Pulmonary Arterial Hypertension.
Kovacs L, Cao Y, Han W, Meadows L, Kovacs-Kasa A, Kondrikov D, Verin AD, Barman SA, Dong Z, Huo Y, Su Y
American journal of respiratory and critical care medicine 2019 Sep 1;200(5):617-627
American journal of respiratory and critical care medicine 2019 Sep 1;200(5):617-627
PFKFB3 Inhibition Attenuates Oxaliplatin-Induced Autophagy and Enhances Its Cytotoxicity in Colon Cancer Cells.
Yan S, Zhou N, Zhang D, Zhang K, Zheng W, Bao Y, Yang W
International journal of molecular sciences 2019 Oct 30;20(21)
International journal of molecular sciences 2019 Oct 30;20(21)
Monocarboxylate transporter 1 promotes classical microglial activation and pro-inflammatory effect via 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3.
Kong L, Wang Z, Liang X, Wang Y, Gao L, Ma C
Journal of neuroinflammation 2019 Nov 28;16(1):240
Journal of neuroinflammation 2019 Nov 28;16(1):240
Phostine 3.1a as a pharmacological compound with antiangiogenic properties against diseases with excess vascularization.
Bousseau S, Marchand M, Soleti R, Vergori L, Hilairet G, Recoquillon S, Le Mao M, Gueguen N, Khiati S, Clarion L, Bakalara N, Martinez MC, Germain S, Lenaers G, Andriantsitohaina R
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 May;33(5):5864-5875
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 May;33(5):5864-5875
Andrographolide attenuates imbalance of gastric vascular homeostasis induced by ethanol through glycolysis pathway.
Yao H, Wu Z, Xu Y, Xu H, Lou G, Jiang Q, Fan W, Liu W, Zheng C, Gao Y, Wang Y
Scientific reports 2019 Mar 21;9(1):4968
Scientific reports 2019 Mar 21;9(1):4968
PFKFB3/HIF-1α feedback loop modulates sorafenib resistance in hepatocellular carcinoma cells.
Long Q, Zou X, Song Y, Duan Z, Liu L
Biochemical and biophysical research communications 2019 Jun 4;513(3):642-650
Biochemical and biophysical research communications 2019 Jun 4;513(3):642-650
Increased 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 activity in response to EGFR signaling contributes to non-small cell lung cancer cell survival.
Lypova N, Telang S, Chesney J, Imbert-Fernandez Y
The Journal of biological chemistry 2019 Jul 5;294(27):10530-10543
The Journal of biological chemistry 2019 Jul 5;294(27):10530-10543
CircACC1 Regulates Assembly and Activation of AMPK Complex under Metabolic Stress.
Li Q, Wang Y, Wu S, Zhou Z, Ding X, Shi R, Thorne RF, Zhang XD, Hu W, Wu M
Cell metabolism 2019 Jul 2;30(1):157-173.e7
Cell metabolism 2019 Jul 2;30(1):157-173.e7
The Glycolytic Enzyme PFKFB3 Controls TNF-α-Induced Endothelial Proinflammatory Responses.
Zhang R, Li R, Liu Y, Li L, Tang Y
Inflammation 2019 Feb;42(1):146-155
Inflammation 2019 Feb;42(1):146-155
PFKFB3 promotes endotoxemia-induced myocardial dysfunction through inflammatory signaling and apoptotic induction.
Tian W, Guo HS, Li CY, Cao W, Wang XY, Mo D, Hao XW, Feng YD, Sun Y, Lei F, Zhang HN, Zhao MG, Li XQ
Toxicology and applied pharmacology 2019 Apr 1;368:26-36
Toxicology and applied pharmacology 2019 Apr 1;368:26-36
Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination.
Gustafsson NMS, Färnegårdh K, Bonagas N, Ninou AH, Groth P, Wiita E, Jönsson M, Hallberg K, Lehto J, Pennisi R, Martinsson J, Norström C, Hollers J, Schultz J, Andersson M, Markova N, Marttila P, Kim B, Norin M, Olin T, Helleday T
Nature communications 2018 Sep 24;9(1):3872
Nature communications 2018 Sep 24;9(1):3872
Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis.
Liu Z, Yan S, Wang J, Xu Y, Wang Y, Zhang S, Xu X, Yang Q, Zeng X, Zhou Y, Gu X, Lu S, Fu Z, Fulton DJ, Weintraub NL, Caldwell RB, Zhang W, Wu C, Liu XL, Chen JF, Ahmad A, Kaddour-Djebbar I, Al-Shabrawey M, Li Q, Jiang X, Sun Y, Sodhi A, Smith L, Hong M, Huo Y
Nature communications 2017 Sep 19;8(1):584
Nature communications 2017 Sep 19;8(1):584
Ginkgetin induces cell death in breast cancer cells via downregulation of the estrogen receptor.
Park Y, Woo SH, Seo SK, Kim H, Noh WC, Lee JK, Kwon BM, Min KN, Choe TB, Park IC
Oncology letters 2017 Oct;14(4):5027-5033
Oncology letters 2017 Oct;14(4):5027-5033
Exercise-Induced Changes in Glucose Metabolism Promote Physiological Cardiac Growth.
Gibb AA, Epstein PN, Uchida S, Zheng Y, McNally LA, Obal D, Katragadda K, Trainor P, Conklin DJ, Brittian KR, Tseng MT, Wang J, Jones SP, Bhatnagar A, Hill BG
Circulation 2017 Nov 28;136(22):2144-2157
Circulation 2017 Nov 28;136(22):2144-2157
FGF-dependent metabolic control of vascular development.
Yu P, Wilhelm K, Dubrac A, Tung JK, Alves TC, Fang JS, Xie Y, Zhu J, Chen Z, De Smet F, Zhang J, Jin SW, Sun L, Sun H, Kibbey RG, Hirschi KK, Hay N, Carmeliet P, Chittenden TW, Eichmann A, Potente M, Simons M
Nature 2017 May 11;545(7653):224-228
Nature 2017 May 11;545(7653):224-228
USP9X regulates centrosome duplication and promotes breast carcinogenesis.
Li X, Song N, Liu L, Liu X, Ding X, Song X, Yang S, Shan L, Zhou X, Su D, Wang Y, Zhang Q, Cao C, Ma S, Yu N, Yang F, Wang Y, Yao Z, Shang Y, Shi L
Nature communications 2017 Mar 31;8:14866
Nature communications 2017 Mar 31;8:14866
6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase-3 is required for transforming growth factor β1-enhanced invasion of Panc1 cells in vitro.
Yalcin A, Solakoglu TH, Ozcan SC, Guzel S, Peker S, Celikler S, Balaban BD, Sevinc E, Gurpinar Y, Chesney JA
Biochemical and biophysical research communications 2017 Mar 11;484(3):687-693
Biochemical and biophysical research communications 2017 Mar 11;484(3):687-693
PFKFB3, a Direct Target of p63, Is Required for Proliferation and Inhibits Differentiation in Epidermal Keratinocytes.
Hamanaka RB, Mutlu GM
The Journal of investigative dermatology 2017 Jun;137(6):1267-1276
The Journal of investigative dermatology 2017 Jun;137(6):1267-1276
PFKFB3-Driven Macrophage Glycolytic Metabolism Is a Crucial Component of Innate Antiviral Defense.
Jiang H, Shi H, Sun M, Wang Y, Meng Q, Guo P, Cao Y, Chen J, Gao X, Li E, Liu J
Journal of immunology (Baltimore, Md. : 1950) 2016 Oct 1;197(7):2880-90
Journal of immunology (Baltimore, Md. : 1950) 2016 Oct 1;197(7):2880-90
Inhibition of 6-phosphofructo-2-kinase (PFKFB3) suppresses glucose metabolism and the growth of HER2+ breast cancer.
O'Neal J, Clem A, Reynolds L, Dougherty S, Imbert-Fernandez Y, Telang S, Chesney J, Clem BF
Breast cancer research and treatment 2016 Nov;160(1):29-40
Breast cancer research and treatment 2016 Nov;160(1):29-40
p53 coordinates DNA repair with nucleotide synthesis by suppressing PFKFB3 expression and promoting the pentose phosphate pathway.
Franklin DA, He Y, Leslie PL, Tikunov AP, Fenger N, Macdonald JM, Zhang Y
Scientific reports 2016 Nov 30;6:38067
Scientific reports 2016 Nov 30;6:38067
Type 2 Diabetes Dysregulates Glucose Metabolism in Cardiac Progenitor Cells.
Salabei JK, Lorkiewicz PK, Mehra P, Gibb AA, Haberzettl P, Hong KU, Wei X, Zhang X, Li Q, Wysoczynski M, Bolli R, Bhatnagar A, Hill BG
The Journal of biological chemistry 2016 Jun 24;291(26):13634-48
The Journal of biological chemistry 2016 Jun 24;291(26):13634-48
Glucose and Palmitate Differentially Regulate PFKFB3/iPFK2 and Inflammatory Responses in Mouse Intestinal Epithelial Cells.
Botchlett R, Li H, Guo X, Qi T, Zhao J, Zheng J, Woo SL, Pei Y, Liu M, Hu X, Chen G, Guo T, Yang S, Li Q, Xiao X, Huo Y, Wu C
Scientific reports 2016 Jul 8;6:28963
Scientific reports 2016 Jul 8;6:28963
IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3.
Reid MA, Lowman XH, Pan M, Tran TQ, Warmoes MO, Ishak Gabra MB, Yang Y, Locasale JW, Kong M
Genes & development 2016 Aug 15;30(16):1837-51
Genes & development 2016 Aug 15;30(16):1837-51
Metabolic control of the cell cycle.
Kalucka J, Missiaen R, Georgiadou M, Schoors S, Lange C, De Bock K, Dewerchin M, Carmeliet P
Cell cycle (Georgetown, Tex.) 2015;14(21):3379-88
Cell cycle (Georgetown, Tex.) 2015;14(21):3379-88
The monocarboxylate transporter 4 is required for glycolytic reprogramming and inflammatory response in macrophages.
Tan Z, Xie N, Banerjee S, Cui H, Fu M, Thannickal VJ, Liu G
The Journal of biological chemistry 2015 Jan 2;290(1):46-55
The Journal of biological chemistry 2015 Jan 2;290(1):46-55
Glycolytic Reprogramming in Myofibroblast Differentiation and Lung Fibrosis.
Xie N, Tan Z, Banerjee S, Cui H, Ge J, Liu RM, Bernard K, Thannickal VJ, Liu G
American journal of respiratory and critical care medicine 2015 Dec 15;192(12):1462-74
American journal of respiratory and critical care medicine 2015 Dec 15;192(12):1462-74
miR-26b inhibits proliferation, migration, invasion and apoptosis induction via the downregulation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 driven glycolysis in osteosarcoma cells.
Du JY, Wang LF, Wang Q, Yu LD
Oncology reports 2015 Apr;33(4):1890-8
Oncology reports 2015 Apr;33(4):1890-8
Estradiol stimulates glucose metabolism via 6-phosphofructo-2-kinase (PFKFB3).
Imbert-Fernandez Y, Clem BF, O'Neal J, Kerr DA, Spaulding R, Lanceta L, Clem AL, Telang S, Chesney J
The Journal of biological chemistry 2014 Mar 28;289(13):9440-8
The Journal of biological chemistry 2014 Mar 28;289(13):9440-8
Endothelial PFKFB3 plays a critical role in angiogenesis.
Xu Y, An X, Guo X, Habtetsion TG, Wang Y, Xu X, Kandala S, Li Q, Li H, Zhang C, Caldwell RB, Fulton DJ, Su Y, Hoda MN, Zhou G, Wu C, Huo Y
Arteriosclerosis, thrombosis, and vascular biology 2014 Jun;34(6):1231-9
Arteriosclerosis, thrombosis, and vascular biology 2014 Jun;34(6):1231-9
6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27.
Yalcin A, Clem BF, Imbert-Fernandez Y, Ozcan SC, Peker S, O'Neal J, Klarer AC, Clem AL, Telang S, Chesney J
Cell death & disease 2014 Jul 17;5:e1337
Cell death & disease 2014 Jul 17;5:e1337
Inhibition of 6-phosphofructo-2-kinase (PFKFB3) induces autophagy as a survival mechanism.
Klarer AC, O'Neal J, Imbert-Fernandez Y, Clem A, Ellis SR, Clark J, Clem B, Chesney J, Telang S
Cancer & metabolism 2014 Jan 23;2(1):2
Cancer & metabolism 2014 Jan 23;2(1):2
Role of PFKFB3-driven glycolysis in vessel sprouting.
De Bock K, Georgiadou M, Schoors S, Kuchnio A, Wong BW, Cantelmo AR, Quaegebeur A, Ghesquière B, Cauwenberghs S, Eelen G, Phng LK, Betz I, Tembuyser B, Brepoels K, Welti J, Geudens I, Segura I, Cruys B, Bifari F, Decimo I, Blanco R, Wyns S, Vangindertael J, Rocha S, Collins RT, Munck S, Daelemans D, Imamura H, Devlieger R, Rider M, Van Veldhoven PP, Schuit F, Bartrons R, Hofkens J, Fraisl P, Telang S, Deberardinis RJ, Schoonjans L, Vinckier S, Chesney J, Gerhardt H, Dewerchin M, Carmeliet P
Cell 2013 Aug 1;154(3):651-63
Cell 2013 Aug 1;154(3):651-63
Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation.
Telang S, Clem BF, Klarer AC, Clem AL, Trent JO, Bucala R, Chesney J
Journal of translational medicine 2012 May 16;10:95
Journal of translational medicine 2012 May 16;10:95
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse thymus tissue were subjected to SDS PAGE followed by western blot with 13763-1-AP(PFKFB3 antibody) at dilution of 1:600
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PFKFB3-Specific antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PFKFB3-Specific. This antibody recognizes human,mouse,rat antigen. The PFKFB3-Specific antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver cancer using 13763-1-AP(PFKFB3 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver cancer using 13763-1-AP(PFKFB3 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue