304310

antibody from BioLegend
Targeting: ITGA4 CD49D
Provider product page for 304310
Immunohistochemistry
Flow cytometry
Other assay

Antibody data

Product number
304310 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#304310, RRID:AB_2130039
Product name
LEAF™ Purified anti-human CD49d [9F10]
Antibody type
Monoclonal
Antigen
CD49d
Description
CD49d is a 150 kD α integrin chain known as α4 integrin or VLA-4 α chain. It forms a heterodimer with either integrin β1 (α4β1, VLA-4) or β7 (α4β7). CD49d is expressed broadly on T lymphocytes, B lymphocytes, monocytes, thymocytes, eosinophils, basophils, mast cells, NK cells, dendritic cells, and some non-hematopoietic cells, but not on normal red blood cells, platelets or neutrophils. VLA-4 binds to VCAM-1 (CD106) and fibronectin. α4β7 is the receptor for VCAM-1 and MAdCAM-1. CD49d participates in mononuclear cell trafficking to endothelial sites of inflammation and has roles in cell-cell interactions and cell adhesion to extracellular matrices. CD49d is involved in lymphocyte migration, T cell activation, and hematopoietic stem cell differentiation. CD49d is a marker to isolate pure populations of Treg cells due to its absence on Foxp3+ cells. The 9F10 antibody is able to costimulate T cell activation.
Reactivity
Human, Bovine, Canine, Feline, Horse, Sheep, Simian
Host
Mouse
Conjugate
Unconjugated
Isotype
IgG
Vial size
500 µg
Concentration
1 mg/ml
Storage
The antibody solution should be stored undiluted at 4 °C. This LEAF™ solution contains no preservative; handle under aseptic conditions.
ITGA4 protein structure - 304310 shown in red.