616202

antibody from BioLegend

Targeting: FGFR1 BFGFR, CD331, CEK, FLG, FLT2, H2, H3, H4, H5, KAL2, N-SAM

Western blot (Data presented on provider website)

Antibody Data

Product number

616202

Provider

BioLegend

Product name

Purified anti-FGFR1

Antibody type

Polyclonal

Antigen

Recombinant (partial), N-terminal

Description

FGFR1 (fibroblast growth factor receptor 1) is a member of the fibroblast growth factor receptor family containing an Ig-like domain and a tyrosine kinase domain. This receptor has multiple isoforms and is a Type I membrane protein. FGFR1 is a widely expressed membrane receptor, with distinct isoforms expressed in specific tissues. FGFR1 binds fibroblast growth factor and induces mitogenesis and cellular differentiation. Defects in FGFR1 result in Pfeiffer syndrome associated with craniosynostosis. This receptor can be upregulated by TGF-β1 in lung fibroblasts and by platelet derived growth factor-BB in fibroblasts. FGFR1 can be modified by phosphorylation and can bind basic/acidic fibroblast factor depending on the receptor isoform. FGFR1 has been shown to interact with N-cadherin and NCAM. ThePoly6162 antibody recognizes human FGFR1 (multiple isoforms) and has been shown to be useful for Western blotting.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Vial size

200 µl

Storage

Upon receipt, store frozen at -20° C.