CAPN7

Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The function of the protein encoded by this gene is not known. An orthologue has been found in mouse but it seems to diverge from other family members. The mouse orthologue is thought to be calcium independent with protease activity. [provided by RefSeq, Jul 2008]

Description

Calpain 7

Tissue specificity

Low tissue specificity

Subcell location

Centrosome, Cytosol

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

3 (15206152 - 15252916)

Ensembl ID

ENSG00000131375  (ver. 103.38)

Orthologs

Mouse Capn7: ENSMUSG00000021893

UniProt

Q9Y6W3

neXtProt

NX_Q9Y6W3

Human splice variants
Mouse splice variants

Protein structure