CCNO

This gene encodes a member of the cyclin protein family, and the encoded protein is involved in regulation of the cell cycle. Disruption of this gene is associated with primary ciliary dyskinesia-19. Alternative splicing results in multiple transcript variants. This gene, which has a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase in PubMed ID: 2001396. A later publication, PubMed ID: 8419333, identified this gene's product as a cyclin protein family member. The UNG2 symbol is also used as a specific protein isoform name for the UNG gene (GeneID 7374), so confusion exists in the scientific literature and in some databases for these two genes. [provided by RefSeq, Jul 2014]

Description

Cyclin O

Tissue specificity

Tissue enhanced (choroid plexus, pancreas, testis)

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins

Chromosome

5 (55231152 - 55233608)

Ensembl ID

ENSG00000152669  (ver. 103.38)

Orthologs

Mouse Ccno: ENSMUSG00000042417

UniProt

P22674

neXtProt

NX_P22674

Human splice variants
Mouse splice variants

Protein structure