60038

PROCR antibody from STEMCELL Technologies Inc
CCD41, CD201, EPCR
Western blot
Recommended by provider
Immunohistochemistry
Recommended by provider
Flow cytometry
Recommended by provider

Antibody data

Product number
60038
Provider
STEMCELL Technologies Inc
Product name
Anti-Mouse EPCR Antibody, Clone RMEPCR1560 (1560)
Provider product page
STEMCELL Technologies Inc - 60038
Antibody type
Monoclonal
Description
The RMEPCR1560 (1560) antibody reacts with the endothelial protein C receptor (EPCR or CD201), an ~25 kDa type I transmembrane glycoprotein expressed by endothelial cells, subsets of hematopoietic stem cells (HSCs) and dendritic cells, and several malignant cell lines. It is also found in a soluble form in plasma. EPCR exhibits homology with the MHC class 1/CD1 protein family. EPCR binds protein C and activated protein C, thus augmenting protein C activation by the thrombin-thrombomodulin complex and regulating blood coagulation and inflammation. EPCR protein expression has been detected on ~1.5% of mouse bone marrow cells. Purified EPCR+ cells are highly enriched for HSC activity, as evidenced by high in vivo repopulation activity. Moreover, EPCR expression is associated with the stem cell activity of bone marrow cell populations isolated using conventional markers, indicating the usefulness of EPCR as a single marker for the identification of mouse HSCs.
Reactivity
Mouse
Host
Mouse
Isotype
IgG
Vial size
100 µg
Storage
2 - 8°C
Provider Type Product Number
- No reagents -