DPABH-23412

antibody from Creative Diagnostics

Targeting: ZFP36 G0S24, NUP475, RNF162A, TIS11, TTP

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

DPABH-23412

Provider

Creative Diagnostics

Proper citation

Creative Diagnostics Cat#DPABH-23412, RRID:AB_2505490

Product name

Rabbit Anti-Human ZFP36 Polyclonal antibody

Antibody type

Polyclonal

Description

The expression of many cytokines is regulated post-transcriptionally by factors that modulate mRNA transport, translation, and stability. Much of this regulation occurs by the binding and stabilizing, or destabilizing, of cytokine mRNAs by proteins that recognize adenosine and uridine-rich elements (AREs) in untranslated regions of target transcripts. Zfp36 is a mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. It was demonstrated to physically interact with the p65 subunit of nuclear factor-¿¸B leading to decreased nuclear import and diminished transcriptional activation mediated by nuclear factor-¿¸B. It acted by specifically binding ARE-containing mRNAs and promoting their degradation, and has a crucial role in the post-transcriptional regulation of tumor necrosis factor (TNF). The calcualted molecular weight of ZFP36 is 34 kDa, but modified ZFP36 is about 40-45 kDa.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

50 uL