Antibody data
- Antibody Data
- Antigen structure
- References [11]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- GTX13824 - Provider product page
- Provider
- GeneTex
- Proper citation
- GeneTex Cat#GTX13824, RRID:AB_367503
- Product name
- Aurora A antibody [35C1]
- Antibody type
- Monoclonal
- Reactivity
- Human, Mouse
- Host
- Mouse
Submitted references The EGF/hnRNP Q1 axis is involved in tumorigenesis via the regulation of cell cycle-related genes.
Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors.
Aurora kinase A is required for hematopoiesis but is dispensable for murine megakaryocyte endomitosis and differentiation.
Aurora A is a prognostic marker for breast cancer arising in BRCA2 mutation carriers.
Targeting megakaryocytic-induced fibrosis in myeloproliferative neoplasms by AURKA inhibition.
CDKN1A-mediated responsiveness of MLL-AF4-positive acute lymphoblastic leukemia to Aurora kinase-A inhibitors.
Ran GTPase-activating protein 1 is a therapeutic target in diffuse large B-cell lymphoma.
RAS promotes tumorigenesis through genomic instability induced by imbalanced expression of Aurora-A and BRCA2 in midbody during cytokinesis.
Signaling-dependent phosphorylation of mitotic centromere-associated kinesin regulates microtubule depolymerization and its centrosomal localization.
AURKA and BRCA2 expression highly correlate with prognosis of endometrioid ovarian carcinoma.
Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2.
Wang YC, Chang KC, Lin BW, Lee JC, Lai CH, Lin LJ, Yen Y, Lin CS, Yang SJ, Lin PC, Lee CT, Hung LY
Experimental & molecular medicine 2018 Jun 6;50(6):70
Experimental & molecular medicine 2018 Jun 6;50(6):70
Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors.
Richards MW, Burgess SG, Poon E, Carstensen A, Eilers M, Chesler L, Bayliss R
Proceedings of the National Academy of Sciences of the United States of America 2016 Nov 29;113(48):13726-13731
Proceedings of the National Academy of Sciences of the United States of America 2016 Nov 29;113(48):13726-13731
Aurora kinase A is required for hematopoiesis but is dispensable for murine megakaryocyte endomitosis and differentiation.
Goldenson B, Kirsammer G, Stankiewicz MJ, Wen QJ, Crispino JD
Blood 2015 Mar 26;125(13):2141-50
Blood 2015 Mar 26;125(13):2141-50
Aurora A is a prognostic marker for breast cancer arising in BRCA2 mutation carriers.
Aradottir M, Reynisdottir ST, Stefansson OA, Jonasson JG, Sverrisdottir A, Tryggvadottir L, Eyfjord JE, Bodvarsdottir SK
The journal of pathology. Clinical research 2015 Jan;1(1):33-40
The journal of pathology. Clinical research 2015 Jan;1(1):33-40
Targeting megakaryocytic-induced fibrosis in myeloproliferative neoplasms by AURKA inhibition.
Wen QJ, Yang Q, Goldenson B, Malinge S, Lasho T, Schneider RK, Breyfogle LJ, Schultz R, Gilles L, Koppikar P, Abdel-Wahab O, Pardanani A, Stein B, Gurbuxani S, Mullally A, Levine RL, Tefferi A, Crispino JD
Nature medicine 2015 Dec;21(12):1473-80
Nature medicine 2015 Dec;21(12):1473-80
CDKN1A-mediated responsiveness of MLL-AF4-positive acute lymphoblastic leukemia to Aurora kinase-A inhibitors.
Chen YP, Lin HJ, Chen JS, Tsai MY, Hsieh HP, Chang JY, Chen NF, Chang KC, Huang WT, Su WC, Yang ST, Chang WC, Hung LY, Chen TY
International journal of cancer 2014 Aug 1;135(3):751-62
International journal of cancer 2014 Aug 1;135(3):751-62
Ran GTPase-activating protein 1 is a therapeutic target in diffuse large B-cell lymphoma.
Chang KC, Chang WC, Chang Y, Hung LY, Lai CH, Yeh YM, Chou YW, Chen CH
PloS one 2013;8(11):e79863
PloS one 2013;8(11):e79863
RAS promotes tumorigenesis through genomic instability induced by imbalanced expression of Aurora-A and BRCA2 in midbody during cytokinesis.
Yang G, Mercado-Uribe I, Multani AS, Sen S, Shih IeM, Wong KK, Gershenson DM, Liu J
International journal of cancer 2013 Jul 15;133(2):275-85
International journal of cancer 2013 Jul 15;133(2):275-85
Signaling-dependent phosphorylation of mitotic centromere-associated kinesin regulates microtubule depolymerization and its centrosomal localization.
Pakala SB, Nair VS, Reddy SD, Kumar R
The Journal of biological chemistry 2012 Nov 23;287(48):40560-9
The Journal of biological chemistry 2012 Nov 23;287(48):40560-9
AURKA and BRCA2 expression highly correlate with prognosis of endometrioid ovarian carcinoma.
Yang F, Guo X, Yang G, Rosen DG, Liu J
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2011 Jun;24(6):836-45
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2011 Jun;24(6):836-45
Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2.
Yang G, Chang B, Yang F, Guo X, Cai KQ, Xiao XS, Wang H, Sen S, Hung MC, Mills GB, Chang S, Multani AS, Mercado-Uribe I, Liu J
Clinical cancer research : an official journal of the American Association for Cancer Research 2010 Jun 15;16(12):3171-81
Clinical cancer research : an official journal of the American Association for Cancer Research 2010 Jun 15;16(12):3171-81
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- Experimental details
- Recombinant Aurora kinase detected with Mouse anti-Aurora-A kinase (GTX13824)