Antibody data
- Antibody Data
- Antigen structure
- References [96]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
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- Product number
- 14052-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14052-1-AP, RRID:AB_10642144
- Product name
- CDK6 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CDK6 antibody (Cat. #14052-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references High PHD Finger Protein 19 (PHF19) expression predicts poor prognosis in colorectal cancer: a retrospective study.
CUX1 Facilitates the Development of Oncogenic Properties Via Activating Wnt/β-Catenin Signaling Pathway in Glioma.
NEK2 plays an active role in Tumorigenesis and Tumor Microenvironment in Non-Small Cell Lung Cancer.
Deletion of p16 accelerates fracture healing in geriatric mice.
CDC37L1 acts as a suppressor of migration and proliferation in gastric cancer by down-regulating CDK6.
A Genome-Scale CRISPR Knock-Out Screen Identifies MicroRNA-5197-5p as a Promising Radiosensitive Biomarker in Colorectal Cancer.
KDELR2 promotes breast cancer proliferation via HDAC3-mediated cell cycle progression.
Knockdown of CLN5 inhibits the tumorigenic properties of glioblastoma cells via the Akt/mTOR signaling pathway.
eIF6 promotes the malignant progression of human hepatocellular carcinoma via the mTOR signaling pathway.
miR-30a-5p Inhibits Epithelial-to-Mesenchymal Transition by Targeting CDK6 in Nasal Polyps.
miRNA in food simultaneously controls animal viral disease and human tumorigenesis.
AMD3465 (hexahydrobromide) rescues the MG63 osteoblasts against the apoptosis induced by high glucose.
Puromycin-sensitive aminopeptidase is required for C2C12 myoblast proliferation and differentiation.
ActivinA activates Notch1-Shh signaling to regulate proliferation in C2C12 skeletal muscle cells.
RabGEF1 functions as an oncogene in U251 glioblastoma cells and is involved in regulating AKT and Erk pathways.
Nobiletin downregulates the SKP2-p21/p27-CDK2 axis to inhibit tumor progression and shows synergistic effects with palbociclib on renal cell carcinoma.
Highly penetrating nanobubble polymer enhances LINC00511-siRNA delivery for improving the chemosensitivity of triple-negative breast cancer.
Cell division cycle associated 8: A novel diagnostic and prognostic biomarker for hepatocellular carcinoma.
Ring finger protein 19A is overexpressed in non-small cell lung cancer and mediates p53 ubiquitin-degradation to promote cancer growth.
SETD4 in the Proliferation, Migration, Angiogenesis, Myogenic Differentiation and Genomic Methylation of Bone Marrow Mesenchymal Stem Cells.
HHLA2 deficiency inhibits non-small cell lung cancer progression and THP-1 macrophage M2 polarization.
ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer.
LncRNA LINC00680 promotes lung adenocarcinoma growth via binding to GATA6 and canceling GATA6-mediated suppression of SOX12 expression.
Safrana l Prevents Prostate Cancer Recurrence by Blocking the Re-activation of Quiescent Cancer Cells via Downregulation of S-Phase Kinase-Associated Protein 2.
Silencing of ELK3 Induces S-M Phase Arrest and Apoptosis and Upregulates SERPINE1 Expression Reducing Migration in Prostate Cancer Cells.
TMED3 Promotes Proliferation and Migration in Breast Cancer Cells by Activating Wnt/β-Catenin Signaling.
NCAPG Induces Cell Proliferation in Cardia Adenocarcinoma via PI3K/AKT Signaling Pathway.
Overexpression of KIAA0101 Promotes the Progression of Non-small Cell Lung Cancer.
LncRNA CYTOR promotes pancreatic cancer cell proliferation and migration by sponging miR-205-5p.
Long non-coding RNA FAM133B-2 represses the radio-resistance of nasopharyngeal cancer cells by targeting miR-34a-5p/CDK6 axis.
UBAC2 promotes bladder cancer proliferation through BCRC-3/miRNA-182-5p/p27 axis.
Novel copper complex CTB regulates methionine cycle induced TERT hypomethylation to promote HCC cells senescence via mitochondrial SLC25A26.
Steroid receptor RNA activator inhibits the migration, invasion and stemness characteristics of renal cell carcinoma cells.
Mitochondrial UQCC3 Modulates Hypoxia Adaptation by Orchestrating OXPHOS and Glycolysis in Hepatocellular Carcinoma.
Combined treatment of mitoxantrone sensitizes breast cancer cells to rapalogs through blocking eEF-2K-mediated activation of Akt and autophagy.
Long non-coding RNA OIP5-AS1 promotes pancreatic cancer cell growth through sponging miR-342-3p via AKT/ERK signaling pathway.
MicroRNA‑145‑5p inhibits osteosarcoma cell proliferation by targeting E2F transcription factor 3.
SOX1 promotes differentiation of nasopharyngeal carcinoma cells by activating retinoid metabolic pathway.
Novel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways.
Cell adhesion molecule 4 suppresses cell growth and metastasis by inhibiting the Akt signaling pathway in non-small cell lung cancer.
Knockdown of KRT17 decreases osteosarcoma cell proliferation and the Warburg effect via the AKT/mTOR/HIF1α pathway.
miR-744-5p mediates lncRNA HOTTIP to regulate the proliferation and apoptosis of papillary thyroid carcinoma cells.
Voltage-gated sodium channels β3 subunit promotes tumorigenesis in hepatocellular carcinoma by facilitating p53 degradation.
CCND1, NOP14 and DNMT3B are involved in miR-502-5p-mediated inhibition of cell migration and proliferation in bladder cancer.
ERO1L promotes NSCLC development by modulating cell cycle-related molecules.
Latcripin-7A, derivative of Lentinula edodes C91-3, reduces migration and induces apoptosis, autophagy, and cell cycle arrest at G1 phase in breast cancer cells.
lncRNA RP11-624L4.1 Is Associated with Unfavorable Prognosis and Promotes Proliferation via the CDK4/6-Cyclin D1-Rb-E2F1 Pathway in NPC.
S119N Mutation of the E3 Ubiquitin Ligase SPOP Suppresses SLC7A1 Degradation to Regulate Hepatoblastoma Progression.
METTL3/YTHDF2 m6 A axis promotes tumorigenesis by degrading SETD7 and KLF4 mRNAs in bladder cancer.
Loss of hnRNPA2B1 inhibits malignant capability and promotes apoptosis via down-regulating Lin28B expression in ovarian cancer.
MicroRNA-16 participates in the cell cycle alteration of HepG2 cells induced by MC-LR.
Inhibition of SMYD2 suppresses tumor progression by down-regulating microRNA-125b and attenuates multi-drug resistance in renal cell carcinoma.
P21 and P27 promote tumorigenesis and progression via cell cycle acceleration in seminal vesicles of TRAMP mice.
The effect of MTHFD2 on the proliferation and migration of colorectal cancer cell lines.
Knockdown of SP1/Syncytin1 axis inhibits the proliferation and metastasis through the AKT and ERK1/2 signaling pathways in non-small cell lung cancer.
MicroRNA-330-3p promotes brain metastasis and epithelial-mesenchymal transition via GRIA3 in non-small cell lung cancer.
CircNR3C1 inhibits proliferation of bladder cancer cells by sponging miR-27a-3p and downregulating cyclin D1 expression.
Identification of predictors of drug sensitivity using patient-derived models of esophageal squamous cell carcinoma.
Short-term stimulation with histone deacetylase inhibitor trichostatin a induces epithelial-mesenchymal transition in nasopharyngeal carcinoma cells without increasing cell invasion ability.
Long non-coding RNA PVT1 promotes tumor progression by regulating the miR-143/HK2 axis in gallbladder cancer.
IPO5 promotes the proliferation and tumourigenicity of colorectal cancer cells by mediating RASAL2 nuclear transportation.
Dual regulatory role of CCNA2 in modulating CDK6 and MET-mediated cell-cycle pathway and EMT progression is blocked by miR-381-3p in bladder cancer.
The tumor-suppressive function of miR-1296-5p by targeting EGFR and CDK6 in gastric cancer.
Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90/phosphoinositide 3-kinase alpha (Hsp90/PI3Kα) against cutaneous melanoma.
Fibronectin regulates the self-renewal of rabbit limbal epithelial stem cells by stimulating the Wnt11/Fzd7/ROCK non-canonical Wnt pathway.
MicroRNA-133b suppresses bladder cancer malignancy by targeting TAGLN2-mediated cell cycle.
G1/S cell cycle regulators mediate effects of circadian dysregulation on tumor growth and provide targets for timed anticancer treatment.
Biocompatible PEGylated Gold nanorods function As cytokinesis inhibitors to suppress angiogenesis.
Alpinetin inhibits proliferation and migration of ovarian cancer cells via suppression of STAT3 signaling.
Circular RNA BCRC-3 suppresses bladder cancer proliferation through miR-182-5p/p27 axis.
Synergetic and Antagonistic Molecular Effects Mediated by the Feedback Loop of p53 and JNK between Saikosaponin D and SP600125 on Lung Cancer A549 Cells.
[6]-Gingerol enhances the radiosensitivity of gastric cancer via G2/M phase arrest and apoptosis induction.
Actin-capping protein CapG is associated with prognosis, proliferation and metastasis in human glioma.
8-Cetylberberine inhibits growth of lung cancer in vitro and in vivo.
NIT1 suppresses tumour proliferation by activating the TGFβ1-Smad2/3 signalling pathway in colorectal cancer.
Therapy Effects of Wogonin on Ovarian Cancer Cells.
CDKL1 promotes tumor proliferation and invasion in colorectal cancer.
miR-29a regulated ER-positive breast cancer cell growth and invasion and is involved in the insulin signaling pathway.
The role of the ATM/Chk/P53 pathway in mediating DNA damage in hand-foot syndrome induced by PLD.
Circular RNA 0000096 affects cell growth and migration in gastric cancer.
Shrimp miR-34 from Shrimp Stress Response to Virus Infection Suppresses Tumorigenesis of Breast Cancer.
ANRIL lncRNA triggers efficient therapeutic efficacy by reprogramming the aberrant INK4-hub in melanoma.
LSD1 is Required for Hair Cell Regeneration in Zebrafish.
MicroRNA-33 promotes the replicative senescence of mouse embryonic fibroblasts by suppressing CDK6.
Down-regulation of dihydrofolate reductase inhibits the growth of endothelial EA.hy926 cell through induction of G1 cell cycle arrest via up-regulating p53 and p21(waf1/cip1) expression.
Nogo-B receptor promotes the chemoresistance of human hepatocellular carcinoma via the ubiquitination of p53 protein.
GAS5 Inhibits Gastric Cancer Cell Proliferation Partly by Modulating CDK6.
miRNA-99b-3p functions as a potential tumor suppressor by targeting glycogen synthase kinase-3β in oral squamous cell carcinoma Tca-8113 cells.
miR Profiling Identifies Cyclin-Dependent Kinase 6 Downregulation as a Potential Mechanism of Acquired Cisplatin Resistance in Non-Small-Cell Lung Carcinoma.
Polychlorinated Biphenyl Quinone Metabolite Promotes p53-Dependent DNA Damage Checkpoint Activation, S-Phase Cycle Arrest and Extrinsic Apoptosis in Human Liver Hepatocellular Carcinoma HepG2 Cells.
Tougu Xiaotong formula induces chondrogenic differentiation in association with transforming growth factor-β1 and promotes proliferation in bone marrow stromal cells.
MicroRNA-214 suppresses the proliferation of human hepatocellular carcinoma cells by targeting E2F3.
USP22 promotes the G1/S phase transition by upregulating FoxM1 expression via β-catenin nuclear localization and is associated with poor prognosis in stage II pancreatic ductal adenocarcinoma.
Transcriptional repression of histone deacetylase 3 by the histone demethylase KDM2A is coupled to tumorigenicity of lung cancer cells.
Sj7170, a unique dual-function peptide with a specific α-chymotrypsin inhibitory activity and a potent tumor-activating effect from scorpion venom.
miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics.
Li P, Sun J, Ruan Y, Song L
PeerJ 2021;9:e11551
PeerJ 2021;9:e11551
CUX1 Facilitates the Development of Oncogenic Properties Via Activating Wnt/β-Catenin Signaling Pathway in Glioma.
Feng F, Zhao Z, Zhou Y, Cheng Y, Wu X, Heng X
Frontiers in molecular biosciences 2021;8:705008
Frontiers in molecular biosciences 2021;8:705008
NEK2 plays an active role in Tumorigenesis and Tumor Microenvironment in Non-Small Cell Lung Cancer.
Bai R, Yuan C, Sun W, Zhang J, Luo Y, Gao Y, Li Y, Gong Y, Xie C
International journal of biological sciences 2021;17(8):1995-2008
International journal of biological sciences 2021;17(8):1995-2008
Deletion of p16 accelerates fracture healing in geriatric mice.
Ding Q, Liu H, Liu L, Ma C, Qin H, Wei Y, Ren Y
American journal of translational research 2021;13(10):11107-11125
American journal of translational research 2021;13(10):11107-11125
CDC37L1 acts as a suppressor of migration and proliferation in gastric cancer by down-regulating CDK6.
Li L, Tao X, Li Y, Gao Y, Li Q
Journal of Cancer 2021;12(11):3145-3153
Journal of Cancer 2021;12(11):3145-3153
A Genome-Scale CRISPR Knock-Out Screen Identifies MicroRNA-5197-5p as a Promising Radiosensitive Biomarker in Colorectal Cancer.
Yu S, Li L, Fan K, Li Y, Gao Y
Frontiers in oncology 2021;11:696713
Frontiers in oncology 2021;11:696713
KDELR2 promotes breast cancer proliferation via HDAC3-mediated cell cycle progression.
Wei H, Ma W, Lu X, Liu H, Lin K, Wang Y, Ye Z, Sun L, Huang Z, Pan T, Zhou Z, Cheng EY, Zhang H, Gao P, Zhong X
Cancer communications (London, England) 2021 Sep;41(9):904-920
Cancer communications (London, England) 2021 Sep;41(9):904-920
Knockdown of CLN5 inhibits the tumorigenic properties of glioblastoma cells via the Akt/mTOR signaling pathway.
Xing J, Li Y, Zhao H
Oncology letters 2021 May;21(5):387
Oncology letters 2021 May;21(5):387
eIF6 promotes the malignant progression of human hepatocellular carcinoma via the mTOR signaling pathway.
Sun L, Liu S, Wang X, Zheng X, Chen Y, Shen H
Journal of translational medicine 2021 May 20;19(1):216
Journal of translational medicine 2021 May 20;19(1):216
miR-30a-5p Inhibits Epithelial-to-Mesenchymal Transition by Targeting CDK6 in Nasal Polyps.
Zhang T, Zhou Y, You B, You Y, Yan Y, Zhang J, Pei Y, Zhang W, Chen J
American journal of rhinology & allergy 2021 Mar;35(2):152-163
American journal of rhinology & allergy 2021 Mar;35(2):152-163
miRNA in food simultaneously controls animal viral disease and human tumorigenesis.
Cui Y, Wan H, Zhang X
Molecular therapy. Nucleic acids 2021 Mar 5;23:995-1006
Molecular therapy. Nucleic acids 2021 Mar 5;23:995-1006
AMD3465 (hexahydrobromide) rescues the MG63 osteoblasts against the apoptosis induced by high glucose.
Zhang Z, Wu H, Huang S, Chen L, Chen X, Zhang W, Liao L, Zhang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111476
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111476
Puromycin-sensitive aminopeptidase is required for C2C12 myoblast proliferation and differentiation.
Osana S, Kitajima Y, Suzuki N, Nunomiya A, Takada H, Kubota T, Murayama K, Nagatomi R
Journal of cellular physiology 2021 Jul;236(7):5293-5305
Journal of cellular physiology 2021 Jul;236(7):5293-5305
ActivinA activates Notch1-Shh signaling to regulate proliferation in C2C12 skeletal muscle cells.
Ma L, Li C, Lian S, Xu B, Yuan J, Lu J, Yang H, Guo J, Ji H
Molecular and cellular endocrinology 2021 Jan 1;519:111055
Molecular and cellular endocrinology 2021 Jan 1;519:111055
RabGEF1 functions as an oncogene in U251 glioblastoma cells and is involved in regulating AKT and Erk pathways.
Fan H, Xin T, Dong X, Yang F, Zhang R, Feng S, He D, Guo H, Pang Q
Experimental and molecular pathology 2021 Feb;118:104571
Experimental and molecular pathology 2021 Feb;118:104571
Nobiletin downregulates the SKP2-p21/p27-CDK2 axis to inhibit tumor progression and shows synergistic effects with palbociclib on renal cell carcinoma.
Chen T, Liu L, Zou Y, Hu X, Zhang W, Zhou T, Luo X, Fu W, Xu J
Cancer biology & medicine 2021 Feb 15;18(1):227-244
Cancer biology & medicine 2021 Feb 15;18(1):227-244
Highly penetrating nanobubble polymer enhances LINC00511-siRNA delivery for improving the chemosensitivity of triple-negative breast cancer.
Yuan Y, Li E, Zhao J, Wu B, Na Z, Cheng W, Jing H
Anti-cancer drugs 2021 Feb 1;32(2):178-188
Anti-cancer drugs 2021 Feb 1;32(2):178-188
Cell division cycle associated 8: A novel diagnostic and prognostic biomarker for hepatocellular carcinoma.
Cui XH, Peng QJ, Li RZ, Lyu XJ, Zhu CF, Qin XH
Journal of cellular and molecular medicine 2021 Dec;25(24):11097-11112
Journal of cellular and molecular medicine 2021 Dec;25(24):11097-11112
Ring finger protein 19A is overexpressed in non-small cell lung cancer and mediates p53 ubiquitin-degradation to promote cancer growth.
Cheng Y, Hu Y, Wang H, Zhao Z, Jiang X, Zhang Y, Zhang J, Tong Y, Qiu X
Journal of cellular and molecular medicine 2021 Aug;25(16):7796-7808
Journal of cellular and molecular medicine 2021 Aug;25(16):7796-7808
SETD4 in the Proliferation, Migration, Angiogenesis, Myogenic Differentiation and Genomic Methylation of Bone Marrow Mesenchymal Stem Cells.
Liao X, Wu C, Shao Z, Zhang S, Zou Y, Wang K, Ha Y, Xing J, Zheng A, Shen Z, Zheng S, Guo J, Jie W
Stem cell reviews and reports 2021 Aug;17(4):1374-1389
Stem cell reviews and reports 2021 Aug;17(4):1374-1389
HHLA2 deficiency inhibits non-small cell lung cancer progression and THP-1 macrophage M2 polarization.
Sun W, Li S, Tang G, Sun S, Luo Y, Bai R, Han L, Jiang X, Gao Y, Huang Z, Zhang J, Gong Y, Xie C
Cancer medicine 2021 Aug;10(15):5256-5269
Cancer medicine 2021 Aug;10(15):5256-5269
ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer.
Taftaf R, Liu X, Singh S, Jia Y, Dashzeveg NK, Hoffmann AD, El-Shennawy L, Ramos EK, Adorno-Cruz V, Schuster EJ, Scholten D, Patel D, Zhang Y, Davis AA, Reduzzi C, Cao Y, D'Amico P, Shen Y, Cristofanilli M, Muller WA, Varadan V, Liu H
Nature communications 2021 Aug 11;12(1):4867
Nature communications 2021 Aug 11;12(1):4867
LncRNA LINC00680 promotes lung adenocarcinoma growth via binding to GATA6 and canceling GATA6-mediated suppression of SOX12 expression.
Sun X, Wang R, Tan M, Tian X, Meng J
Experimental cell research 2021 Aug 1;405(1):112653
Experimental cell research 2021 Aug 1;405(1):112653
Safrana l Prevents Prostate Cancer Recurrence by Blocking the Re-activation of Quiescent Cancer Cells via Downregulation of S-Phase Kinase-Associated Protein 2.
Jiang X, Li Y, Feng JL, Nik Nabil WN, Wu R, Lu Y, Liu H, Xi ZC, Xu HX
Frontiers in cell and developmental biology 2020;8:598620
Frontiers in cell and developmental biology 2020;8:598620
Silencing of ELK3 Induces S-M Phase Arrest and Apoptosis and Upregulates SERPINE1 Expression Reducing Migration in Prostate Cancer Cells.
Mao Y, Li W, Hua B, Gu X, Pan W, Chen Q, Xu B, Wang Z, Lu C
BioMed research international 2020;2020:2406159
BioMed research international 2020;2020:2406159
TMED3 Promotes Proliferation and Migration in Breast Cancer Cells by Activating Wnt/β-Catenin Signaling.
Zhang X, Luo Y, Li Q
OncoTargets and therapy 2020;13:5819-5830
OncoTargets and therapy 2020;13:5819-5830
NCAPG Induces Cell Proliferation in Cardia Adenocarcinoma via PI3K/AKT Signaling Pathway.
Zhang X, Wang H, Han Y, Zhu M, Song Z, Zhan D, Jia J
OncoTargets and therapy 2020;13:11315-11326
OncoTargets and therapy 2020;13:11315-11326
Overexpression of KIAA0101 Promotes the Progression of Non-small Cell Lung Cancer.
Cao H, Zheng J, Yao Y, Yang Q, Yan R, Sun W, Ruan K, Zhou J, Zhou J
Journal of Cancer 2020;11(22):6663-6674
Journal of Cancer 2020;11(22):6663-6674
LncRNA CYTOR promotes pancreatic cancer cell proliferation and migration by sponging miR-205-5p.
Zhu H, Shan Y, Ge K, Lu J, Kong W, Jia C
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2020 Sep;20(6):1139-1148
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2020 Sep;20(6):1139-1148
Long non-coding RNA FAM133B-2 represses the radio-resistance of nasopharyngeal cancer cells by targeting miR-34a-5p/CDK6 axis.
Huang D, Zhu X, Wang Y, Yu H, Pu Y
Aging 2020 Sep 5;12(17):16936-16950
Aging 2020 Sep 5;12(17):16936-16950
UBAC2 promotes bladder cancer proliferation through BCRC-3/miRNA-182-5p/p27 axis.
Gu C, Zhao K, Zhou N, Liu F, Xie F, Yu S, Feng Y, Chen L, Yang J, Tian F, Jiang G
Cell death & disease 2020 Sep 10;11(9):733
Cell death & disease 2020 Sep 10;11(9):733
Novel copper complex CTB regulates methionine cycle induced TERT hypomethylation to promote HCC cells senescence via mitochondrial SLC25A26.
Jin C, Li Y, Su Y, Guo Z, Wang X, Wang S, Zhang F, Zhang Z, Shao J, Zheng S
Cell death & disease 2020 Oct 11;11(10):844
Cell death & disease 2020 Oct 11;11(10):844
Steroid receptor RNA activator inhibits the migration, invasion and stemness characteristics of renal cell carcinoma cells.
Zhang C, Zhu N, Liu C, Wu H, Yin Y, Shi Y, Liao D, Qin L
International journal of molecular medicine 2020 Nov;46(5):1765-1776
International journal of molecular medicine 2020 Nov;46(5):1765-1776
Mitochondrial UQCC3 Modulates Hypoxia Adaptation by Orchestrating OXPHOS and Glycolysis in Hepatocellular Carcinoma.
Yang Y, Zhang G, Guo F, Li Q, Luo H, Shu Y, Shen Y, Gan J, Xu L, Yang H
Cell reports 2020 Nov 3;33(5):108340
Cell reports 2020 Nov 3;33(5):108340
Combined treatment of mitoxantrone sensitizes breast cancer cells to rapalogs through blocking eEF-2K-mediated activation of Akt and autophagy.
Guan Y, Jiang S, Ye W, Ren X, Wang X, Zhang Y, Yin M, Wang K, Tao Y, Yang J, Cao D, Cheng Y
Cell death & disease 2020 Nov 3;11(11):948
Cell death & disease 2020 Nov 3;11(11):948
Long non-coding RNA OIP5-AS1 promotes pancreatic cancer cell growth through sponging miR-342-3p via AKT/ERK signaling pathway.
Meng X, Ma J, Wang B, Wu X, Liu Z
Journal of physiology and biochemistry 2020 May;76(2):301-315
Journal of physiology and biochemistry 2020 May;76(2):301-315
MicroRNA‑145‑5p inhibits osteosarcoma cell proliferation by targeting E2F transcription factor 3.
Li H, Pan R, Lu Q, Ren C, Sun J, Wu H, Wen J, Chen H
International journal of molecular medicine 2020 May;45(5):1317-1326
International journal of molecular medicine 2020 May;45(5):1317-1326
SOX1 promotes differentiation of nasopharyngeal carcinoma cells by activating retinoid metabolic pathway.
Lei XX, Liu Y, Wang JX, Cai Q, Yan M, He HP, Liu Q, Long ZJ, Guan Z
Cell death & disease 2020 May 7;11(5):331
Cell death & disease 2020 May 7;11(5):331
Novel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways.
Zhao Q, Zhu HP, Xie X, Mao Q, Liu YQ, He XH, Peng C, Jiang QL, Huang W
International journal of molecular sciences 2020 Mar 7;21(5)
International journal of molecular sciences 2020 Mar 7;21(5)
Cell adhesion molecule 4 suppresses cell growth and metastasis by inhibiting the Akt signaling pathway in non-small cell lung cancer.
Luo F, Zhao Y, Liu J
The international journal of biochemistry & cell biology 2020 Jun;123:105750
The international journal of biochemistry & cell biology 2020 Jun;123:105750
Knockdown of KRT17 decreases osteosarcoma cell proliferation and the Warburg effect via the AKT/mTOR/HIF1α pathway.
Yan X, Yang C, Hu W, Chen T, Wang Q, Pan F, Qiu B, Tang B
Oncology reports 2020 Jul;44(1):103-114
Oncology reports 2020 Jul;44(1):103-114
miR-744-5p mediates lncRNA HOTTIP to regulate the proliferation and apoptosis of papillary thyroid carcinoma cells.
Yuan Q, Fan Y, Liu Z, Wang X, Jia M, Geng Z, Zheng J, Lu X
Experimental cell research 2020 Jul 1;392(1):112024
Experimental cell research 2020 Jul 1;392(1):112024
Voltage-gated sodium channels β3 subunit promotes tumorigenesis in hepatocellular carcinoma by facilitating p53 degradation.
Li S, Han J, Guo G, Sun Y, Zhang T, Zhao M, Xu Y, Cui Y, Liu Y, Zhang J
FEBS letters 2020 Feb;594(3):497-508
FEBS letters 2020 Feb;594(3):497-508
CCND1, NOP14 and DNMT3B are involved in miR-502-5p-mediated inhibition of cell migration and proliferation in bladder cancer.
Ying Y, Li J, Xie H, Yan H, Jin K, He L, Ma X, Wu J, Xu X, Fang J, Wang X, Zheng X, Liu B, Xie L
Cell proliferation 2020 Feb;53(2):e12751
Cell proliferation 2020 Feb;53(2):e12751
ERO1L promotes NSCLC development by modulating cell cycle-related molecules.
Shi X, Wu J, Liu Y, Jiang Y, Zhi C, Li J
Cell biology international 2020 Dec;44(12):2473-2484
Cell biology international 2020 Dec;44(12):2473-2484
Latcripin-7A, derivative of Lentinula edodes C91-3, reduces migration and induces apoptosis, autophagy, and cell cycle arrest at G1 phase in breast cancer cells.
Din SRU, Zhong M, Nisar MA, Saleem MZ, Hussain A, Khinsar KH, Alam S, Ayub G, Kanwal S, Li X, Zhang W, Wang X, Ning A, Cao J, Huang M
Applied microbiology and biotechnology 2020 Dec;104(23):10165-10179
Applied microbiology and biotechnology 2020 Dec;104(23):10165-10179
lncRNA RP11-624L4.1 Is Associated with Unfavorable Prognosis and Promotes Proliferation via the CDK4/6-Cyclin D1-Rb-E2F1 Pathway in NPC.
Zhou L, Liu R, Liang X, Zhang S, Bi W, Yang M, He Y, Jin J, Li S, Yang X, Fu J, Zhang P
Molecular therapy. Nucleic acids 2020 Dec 4;22:1025-1039
Molecular therapy. Nucleic acids 2020 Dec 4;22:1025-1039
S119N Mutation of the E3 Ubiquitin Ligase SPOP Suppresses SLC7A1 Degradation to Regulate Hepatoblastoma Progression.
He W, Zhang J, Liu B, Liu X, Liu G, Xie L, He J, Wei M, Li K, Ma J, Dong R, Ma D, Dong K, Ye M
Molecular therapy oncolytics 2020 Dec 16;19:149-162
Molecular therapy oncolytics 2020 Dec 16;19:149-162
METTL3/YTHDF2 m6 A axis promotes tumorigenesis by degrading SETD7 and KLF4 mRNAs in bladder cancer.
Xie H, Li J, Ying Y, Yan H, Jin K, Ma X, He L, Xu X, Liu B, Wang X, Zheng X, Xie L
Journal of cellular and molecular medicine 2020 Apr;24(7):4092-4104
Journal of cellular and molecular medicine 2020 Apr;24(7):4092-4104
Loss of hnRNPA2B1 inhibits malignant capability and promotes apoptosis via down-regulating Lin28B expression in ovarian cancer.
Yang Y, Wei Q, Tang Y, Yuanyuan Wang, Luo Q, Zhao H, He M, Wang H, Zeng Q, Lu W, Xu J, Liu T, Yi P
Cancer letters 2020 Apr 10;475:43-52
Cancer letters 2020 Apr 10;475:43-52
MicroRNA-16 participates in the cell cycle alteration of HepG2 cells induced by MC-LR.
Feng Y, Chen X, Ding W, Ma J, Zhang B, Li X
Ecotoxicology and environmental safety 2020 Apr 1;192:110295
Ecotoxicology and environmental safety 2020 Apr 1;192:110295
Inhibition of SMYD2 suppresses tumor progression by down-regulating microRNA-125b and attenuates multi-drug resistance in renal cell carcinoma.
Yan L, Ding B, Liu H, Zhang Y, Zeng J, Hu J, Yao W, Yu G, An R, Chen Z, Ye Z, Xing J, Xiao K, Wu L, Xu H
Theranostics 2019;9(26):8377-8391
Theranostics 2019;9(26):8377-8391
P21 and P27 promote tumorigenesis and progression via cell cycle acceleration in seminal vesicles of TRAMP mice.
Li T, Wang F, Dang Y, Dong J, Zhang Y, Zhang C, Liu P, Gao Y, Wang X, Yang S, Lu S
International journal of biological sciences 2019;15(10):2198-2210
International journal of biological sciences 2019;15(10):2198-2210
The effect of MTHFD2 on the proliferation and migration of colorectal cancer cell lines.
Wei Y, Liu P, Li Q, Du J, Chen Y, Wang Y, Shi H, Wang Y, Zhang H, Xue W, Gao Y, Li D, Feng Y, Yan J, Han J, Zhang J
OncoTargets and therapy 2019;12:6361-6370
OncoTargets and therapy 2019;12:6361-6370
Knockdown of SP1/Syncytin1 axis inhibits the proliferation and metastasis through the AKT and ERK1/2 signaling pathways in non-small cell lung cancer.
Li X, Fu Y, Xia X, Zhang X, Xiao K, Zhuang X, Zhang Y
Cancer medicine 2019 Sep;8(12):5750-5759
Cancer medicine 2019 Sep;8(12):5750-5759
MicroRNA-330-3p promotes brain metastasis and epithelial-mesenchymal transition via GRIA3 in non-small cell lung cancer.
Wei C, Zhang R, Cai Q, Gao X, Tong F, Dong J, Hu Y, Wu G, Dong X
Aging 2019 Sep 8;11(17):6734-6761
Aging 2019 Sep 8;11(17):6734-6761
CircNR3C1 inhibits proliferation of bladder cancer cells by sponging miR-27a-3p and downregulating cyclin D1 expression.
Zheng F, Wang M, Li Y, Huang C, Tao D, Xie F, Zhang H, Sun J, Zhang C, Gu C, Wang Z, Jiang G
Cancer letters 2019 Sep 28;460:139-151
Cancer letters 2019 Sep 28;460:139-151
Identification of predictors of drug sensitivity using patient-derived models of esophageal squamous cell carcinoma.
Su D, Zhang D, Jin J, Ying L, Han M, Chen K, Li B, Wu J, Xie Z, Zhang F, Lin Y, Cheng G, Li JY, Huang M, Wang J, Wang K, Zhang J, Li F, Xiong L, Futreal A, Mao W
Nature communications 2019 Nov 7;10(1):5076
Nature communications 2019 Nov 7;10(1):5076
Short-term stimulation with histone deacetylase inhibitor trichostatin a induces epithelial-mesenchymal transition in nasopharyngeal carcinoma cells without increasing cell invasion ability.
Shen Z, Liao X, Shao Z, Feng M, Yuan J, Wang S, Gan S, Ha Y, He Z, Jie W
BMC cancer 2019 Mar 22;19(1):262
BMC cancer 2019 Mar 22;19(1):262
Long non-coding RNA PVT1 promotes tumor progression by regulating the miR-143/HK2 axis in gallbladder cancer.
Chen J, Yu Y, Li H, Hu Q, Chen X, He Y, Xue C, Ren F, Ren Z, Li J, Liu L, Duan Z, Cui G, Sun R
Molecular cancer 2019 Mar 2;18(1):33
Molecular cancer 2019 Mar 2;18(1):33
IPO5 promotes the proliferation and tumourigenicity of colorectal cancer cells by mediating RASAL2 nuclear transportation.
Zhang W, Lu Y, Li X, Zhang J, Lin W, Zhang W, Zheng L, Li X
Journal of experimental & clinical cancer research : CR 2019 Jul 9;38(1):296
Journal of experimental & clinical cancer research : CR 2019 Jul 9;38(1):296
Dual regulatory role of CCNA2 in modulating CDK6 and MET-mediated cell-cycle pathway and EMT progression is blocked by miR-381-3p in bladder cancer.
Li J, Ying Y, Xie H, Jin K, Yan H, Wang S, Xu M, Xu X, Wang X, Yang K, Zheng X, Xie L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jan;33(1):1374-1388
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jan;33(1):1374-1388
The tumor-suppressive function of miR-1296-5p by targeting EGFR and CDK6 in gastric cancer.
Jia Y, Zhao LM, Bai HY, Zhang C, Dai SL, Lv HL, Shan BE
Bioscience reports 2019 Jan 31;39(1)
Bioscience reports 2019 Jan 31;39(1)
Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90/phosphoinositide 3-kinase alpha (Hsp90/PI3Kα) against cutaneous melanoma.
Qin F, Wang Y, Jiang X, Wang Y, Zhang N, Wen X, Wang L, Jiang Q, He G
Journal of enzyme inhibition and medicinal chemistry 2019 Dec;34(1):909-926
Journal of enzyme inhibition and medicinal chemistry 2019 Dec;34(1):909-926
Fibronectin regulates the self-renewal of rabbit limbal epithelial stem cells by stimulating the Wnt11/Fzd7/ROCK non-canonical Wnt pathway.
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Experimental eye research 2019 Aug;185:107681
Experimental eye research 2019 Aug;185:107681
MicroRNA-133b suppresses bladder cancer malignancy by targeting TAGLN2-mediated cell cycle.
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Journal of cellular physiology 2019 Apr;234(4):4910-4923
Journal of cellular physiology 2019 Apr;234(4):4910-4923
G1/S cell cycle regulators mediate effects of circadian dysregulation on tumor growth and provide targets for timed anticancer treatment.
Lee Y, Lahens NF, Zhang S, Bedont J, Field JM, Sehgal A
PLoS biology 2019 Apr;17(4):e3000228
PLoS biology 2019 Apr;17(4):e3000228
Biocompatible PEGylated Gold nanorods function As cytokinesis inhibitors to suppress angiogenesis.
Song H, Guo T, Zhao Z, Wei Y, Luo H, Weng W, Zhang R, Zhong M, Chen C, Su J, Shen W
Biomaterials 2018 Sep;178:23-35
Biomaterials 2018 Sep;178:23-35
Alpinetin inhibits proliferation and migration of ovarian cancer cells via suppression of STAT3 signaling.
Zhao X, Guo X, Shen J, Hua D
Molecular medicine reports 2018 Oct;18(4):4030-4036
Molecular medicine reports 2018 Oct;18(4):4030-4036
Circular RNA BCRC-3 suppresses bladder cancer proliferation through miR-182-5p/p27 axis.
Xie F, Li Y, Wang M, Huang C, Tao D, Zheng F, Zhang H, Zeng F, Xiao X, Jiang G
Molecular cancer 2018 Oct 3;17(1):144
Molecular cancer 2018 Oct 3;17(1):144
Synergetic and Antagonistic Molecular Effects Mediated by the Feedback Loop of p53 and JNK between Saikosaponin D and SP600125 on Lung Cancer A549 Cells.
Chen X, Liu C, Zhao R, Zhao P, Wu J, Zhou N, Ying M
Molecular pharmaceutics 2018 Nov 5;15(11):4974-4984
Molecular pharmaceutics 2018 Nov 5;15(11):4974-4984
[6]-Gingerol enhances the radiosensitivity of gastric cancer via G2/M phase arrest and apoptosis induction.
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Oncology reports 2018 May;39(5):2252-2260
Oncology reports 2018 May;39(5):2252-2260
Actin-capping protein CapG is associated with prognosis, proliferation and metastasis in human glioma.
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Oncology reports 2018 Mar;39(3):1011-1022
Oncology reports 2018 Mar;39(3):1011-1022
8-Cetylberberine inhibits growth of lung cancer in vitro and in vivo.
Xiao Y, Tian C, Huang T, Han B, Wang M, Ma H, Li Z, Ye X, Li X
Life sciences 2018 Jan 1;192:259-269
Life sciences 2018 Jan 1;192:259-269
NIT1 suppresses tumour proliferation by activating the TGFβ1-Smad2/3 signalling pathway in colorectal cancer.
Lin C, Zhang J, Lu Y, Li X, Zhang W, Zhang W, Lin W, Zheng L, Li X
Cell death & disease 2018 Feb 15;9(3):263
Cell death & disease 2018 Feb 15;9(3):263
Therapy Effects of Wogonin on Ovarian Cancer Cells.
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BioMed research international 2017;2017:9381513
CDKL1 promotes tumor proliferation and invasion in colorectal cancer.
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OncoTargets and therapy 2017;10:1613-1624
OncoTargets and therapy 2017;10:1613-1624
miR-29a regulated ER-positive breast cancer cell growth and invasion and is involved in the insulin signaling pathway.
Li ZH, Xiong QY, Xu L, Duan P, Yang QO, Zhou P, Tu JH
Oncotarget 2017 May 16;8(20):32566-32575
Oncotarget 2017 May 16;8(20):32566-32575
The role of the ATM/Chk/P53 pathway in mediating DNA damage in hand-foot syndrome induced by PLD.
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Toxicology letters 2017 Jan 4;265:131-139
Toxicology letters 2017 Jan 4;265:131-139
Circular RNA 0000096 affects cell growth and migration in gastric cancer.
Li P, Chen H, Chen S, Mo X, Li T, Xiao B, Yu R, Guo J
British journal of cancer 2017 Feb 28;116(5):626-633
British journal of cancer 2017 Feb 28;116(5):626-633
Shrimp miR-34 from Shrimp Stress Response to Virus Infection Suppresses Tumorigenesis of Breast Cancer.
Cui Y, Yang X, Zhang X
Molecular therapy. Nucleic acids 2017 Dec 15;9:387-398
Molecular therapy. Nucleic acids 2017 Dec 15;9:387-398
ANRIL lncRNA triggers efficient therapeutic efficacy by reprogramming the aberrant INK4-hub in melanoma.
Xu S, Wang H, Pan H, Shi Y, Li T, Ge S, Jia R, Zhang H, Fan X
Cancer letters 2016 Oct 10;381(1):41-8
Cancer letters 2016 Oct 10;381(1):41-8
LSD1 is Required for Hair Cell Regeneration in Zebrafish.
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Molecular neurobiology 2016 May;53(4):2421-34
Molecular neurobiology 2016 May;53(4):2421-34
MicroRNA-33 promotes the replicative senescence of mouse embryonic fibroblasts by suppressing CDK6.
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Biochemical and biophysical research communications 2016 May 13;473(4):1064-1070
Biochemical and biophysical research communications 2016 May 13;473(4):1064-1070
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Journal of clinical biochemistry and nutrition 2016 Mar;58(2):105-13
Journal of clinical biochemistry and nutrition 2016 Mar;58(2):105-13
Nogo-B receptor promotes the chemoresistance of human hepatocellular carcinoma via the ubiquitination of p53 protein.
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Oncotarget 2016 Feb 23;7(8):8850-65
Oncotarget 2016 Feb 23;7(8):8850-65
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miRNA-99b-3p functions as a potential tumor suppressor by targeting glycogen synthase kinase-3β in oral squamous cell carcinoma Tca-8113 cells.
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International journal of oncology 2015 Oct;47(4):1528-36
International journal of oncology 2015 Oct;47(4):1528-36
miR Profiling Identifies Cyclin-Dependent Kinase 6 Downregulation as a Potential Mechanism of Acquired Cisplatin Resistance in Non-Small-Cell Lung Carcinoma.
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Oncology letters 2015 Dec;10(6):3779-3784
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 14052-1-AP(CDK6 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using CDK6 antibody 14052-1-AP at 1:50 dilution and FITC-labeled donkey anti-rabbit IgG (green). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human endometrial cancer using 14052-1-AP(CDK6 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human endometrial cancer using 14052-1-AP(CDK6 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue