BS1569

antibody from Bioworld Technology, Inc
Targeting: PAK1
Provider product page for BS1569
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS1569 - Provider product page
Provider
Bioworld Technology, Inc
Proper citation
Bioworld Technology Cat#BS1569, RRID:AB_1664029
Product name
PAK1 (I206) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to amino acids 180-230 of Human PAK1.
Description
Three isoforms of serine/threonine kinases, designated Ï«PAK p68, ÉÇPAK p65 and ÎÛPAK p62, have been shown to exhibit a high degree of sequence homology with the S. cerevisiae kinase Ste 20, involved in pheromone signaling. The Ï«, ÉÇ and ÎÛPAK isoforms complex specifically with Rac1 and Cdc42 in their active GTP-bound state, inhibiting their intrinsic GTPase activity leading to their autophosphorylation. There are eight sites of autophosphorylation on ÎÛPAK, including Ser 19, Ser 141 and Thr 402, and phosphorylation of Ser 141 and Thr 402 is correlated with ÎÛPAK activation. Once phosphorylated and their affinity for Rac/Cdc42 reduced, the PAK isoforms disassociate from the complex to seek downstream substrates.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PAK1 protein structure - BS1569 shown in red.