AGTO-L054E

antibody from Creative Biolabs

Targeting: CHRNE ACHRE

No application information provided.

Antibody Data

Product number

AGTO-L054E

Provider

Creative Biolabs

Product name

anti-CHRNE immunotoxin (Fab)-PE

Antibody type

Monoclonal

Description

This immunotoxin was achieved by conjugating/fusing the Anti-CHRNE Fab to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to Rhabdomyosarcomas (RMS) cells and enters cells by receptor-mediated endocytosis, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treatment of Rhabdomyosarcomas (RMS).

Reactivity

Human

Host

Mouse