AGTO-L054E

CHRNE antibody from Creative Biolabs
ACHRE
Functional assay
Recommended by provider

Antibody data

Product number
AGTO-L054E
Provider
Creative Biolabs
Product name
anti-CHRNE immunotoxin (Fab)-PE
Provider product page
Creative Biolabs - AGTO-L054E
Antibody type
Monoclonal
Description
This immunotoxin was achieved by conjugating/fusing the Anti-CHRNE Fab to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to Rhabdomyosarcomas (RMS) cells and enters cells by receptor-mediated endocytosis, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treatment of Rhabdomyosarcomas (RMS).
Reactivity
Human
Host
Mouse
Provider Type Product Number
- No reagents -