Antibody data
- Antibody Data
- Antigen structure
- References [22]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 13572-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13572-1-AP, RRID:AB_2188915
- Product name
- SIRT6 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SIRT6 antibody (Cat. #13572-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Total Sesquiterpene Glycosides from Loquat Leaves Ameliorate HFD-Induced Insulin Resistance by Modulating IRS-1/GLUT4, TRPV1, and SIRT6/Nrf2 Signaling Pathways.
Bioinformatics Analysis of the SIRT Family Members and Assessment of Their Potential Clinical Value.
Exercise ameliorates insulin resistance and improves SIRT6-mediated insulin signaling transduction in liver of obese rats.
Sirtuin 6 supra-physiological overexpression in hypothalamic pro-opiomelanocortin neurons promotes obesity via the hypothalamus-adipose axis.
Targeting USP47 overcomes tyrosine kinase inhibitor resistance and eradicates leukemia stem/progenitor cells in chronic myelogenous leukemia.
α-Hederin inhibits the growth of lung cancer A549 cells in vitro and in vivo by decreasing SIRT6 dependent glycolysis.
Age-related changes of human serum Sirtuin6 in adults.
Kisspeptin-10 Maintains the Activation of the mTOR Signaling Pathway by Inhibiting SIRT6 to Promote the Synthesis of Milk in Bovine Mammary Epithelial Cells.
Bone marrow mesenchymal stem cell exosomes suppress phosphate-induced aortic calcification via SIRT6-HMGB1 deacetylation.
The SIRT6-Autophagy-Warburg Effect Axis in Papillary Thyroid Cancer.
The effect of high glucose on the biological characteristics of nucleus pulposus-derived mesenchymal stem cells.
Associations of sirtuins with clinicopathological variables and prognosis in human ovarian cancer.
SIRT6/HIF-1α axis promotes papillary thyroid cancer progression by inducing epithelial-mesenchymal transition.
SIRT6 promotes the Warburg effect of papillary thyroid cancer cell BCPAP through reactive oxygen species.
Comprehensive Analysis of Expression and Prognostic Value of Sirtuins in Ovarian Cancer.
Sirtuin-mediated deacetylation of hnRNP A1 suppresses glycolysis and growth in hepatocellular carcinoma.
Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.
The effect of intervertebral disc degenerative change on biological characteristics of nucleus pulposus mesenchymal stem cell: an in vitro study in rats.
Downregulation of SIRT6 by miR-34c-5p is associated with poor prognosis and promotes colon cancer proliferation through inhibiting apoptosis via the JAK2/STAT3 signaling pathway.
Autophagy activated by SIRT6 regulates Aβ induced inflammatory response in RPEs.
The effect of SIRT6 on the odontoblastic potential of human dental pulp cells.
SIRT6 regulates osteogenic differentiation of rat bone marrow mesenchymal stem cells partially via suppressing the nuclear factor-κB signaling pathway.
Wu R, Jian T, Ding X, Lv H, Meng X, Ren B, Li J, Chen J, Li W
Oxidative medicine and cellular longevity 2021;2021:4706410
Oxidative medicine and cellular longevity 2021;2021:4706410
Bioinformatics Analysis of the SIRT Family Members and Assessment of Their Potential Clinical Value.
Liu M, Yu J, Jin H, Wang S, Ding J, Xing H, He S, Zeng Y
OncoTargets and therapy 2021;14:2635-2649
OncoTargets and therapy 2021;14:2635-2649
Exercise ameliorates insulin resistance and improves SIRT6-mediated insulin signaling transduction in liver of obese rats.
Zhang Y, Yang Z, Xu Z, Wan J, Hua T, Sun Q
Canadian journal of physiology and pharmacology 2021 May;99(5):506-511
Canadian journal of physiology and pharmacology 2021 May;99(5):506-511
Sirtuin 6 supra-physiological overexpression in hypothalamic pro-opiomelanocortin neurons promotes obesity via the hypothalamus-adipose axis.
Tang Q, Liu Q, Yang X, Wu T, Huang C, Zhang J, Zhang Z, Zhang G, Zhao Y, Zhou J, Huang H, Xia Y, Yan J, Li Y, He J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Mar;35(3):e21408
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Mar;35(3):e21408
Targeting USP47 overcomes tyrosine kinase inhibitor resistance and eradicates leukemia stem/progenitor cells in chronic myelogenous leukemia.
Lei H, Xu HZ, Shan HZ, Liu M, Lu Y, Fang ZX, Jin J, Jing B, Xiao XH, Gao SM, Gao FH, Xia L, Yang L, Liu LG, Wang WW, Liu CX, Tong Y, Wu YZ, Zheng JK, Chen GQ, Zhou L, Wu YL
Nature communications 2021 Jan 4;12(1):51
Nature communications 2021 Jan 4;12(1):51
α-Hederin inhibits the growth of lung cancer A549 cells in vitro and in vivo by decreasing SIRT6 dependent glycolysis.
Fang C, Liu Y, Chen L, Luo Y, Cui Y, Zhang N, Liu P, Zhou M, Xie Y
Pharmaceutical biology 2021 Dec;59(1):11-20
Pharmaceutical biology 2021 Dec;59(1):11-20
Age-related changes of human serum Sirtuin6 in adults.
Zhao Y, Bai X, Jia X, Lu Y, Cheng W, Shu M, Zhu Y, Zhu L, Wang L, Shu Y, Song Y, Jin S
BMC geriatrics 2021 Aug 4;21(1):452
BMC geriatrics 2021 Aug 4;21(1):452
Kisspeptin-10 Maintains the Activation of the mTOR Signaling Pathway by Inhibiting SIRT6 to Promote the Synthesis of Milk in Bovine Mammary Epithelial Cells.
Cao Y, Hu G, Zhang Q, Ma L, Wang J, Li W, Ge Y, Cheng J, Yang Z, Fu S, Liu J
Journal of agricultural and food chemistry 2021 Apr 14;69(14):4093-4100
Journal of agricultural and food chemistry 2021 Apr 14;69(14):4093-4100
Bone marrow mesenchymal stem cell exosomes suppress phosphate-induced aortic calcification via SIRT6-HMGB1 deacetylation.
Wei W, Guo X, Gu L, Jia J, Yang M, Yuan W, Rong S
Stem cell research & therapy 2021 Apr 13;12(1):235
Stem cell research & therapy 2021 Apr 13;12(1):235
The SIRT6-Autophagy-Warburg Effect Axis in Papillary Thyroid Cancer.
Yang Z, Huang R, Wei X, Yu W, Min Z, Ye M
Frontiers in oncology 2020;10:1265
Frontiers in oncology 2020;10:1265
The effect of high glucose on the biological characteristics of nucleus pulposus-derived mesenchymal stem cells.
Liu Y, Li Y, Nan LP, Wang F, Zhou SF, Wang JC, Feng XM, Zhang L
Cell biochemistry and function 2020 Mar;38(2):130-140
Cell biochemistry and function 2020 Mar;38(2):130-140
Associations of sirtuins with clinicopathological variables and prognosis in human ovarian cancer.
He Q, Chen K, Ye R, Dai N, Guo P, Wang L
Oncology letters 2020 Apr;19(4):3278-3288
Oncology letters 2020 Apr;19(4):3278-3288
SIRT6/HIF-1α axis promotes papillary thyroid cancer progression by inducing epithelial-mesenchymal transition.
Yang Z, Yu W, Huang R, Ye M, Min Z
Cancer cell international 2019;19:17
Cancer cell international 2019;19:17
SIRT6 promotes the Warburg effect of papillary thyroid cancer cell BCPAP through reactive oxygen species.
Yu W, Yang Z, Huang R, Min Z, Ye M
OncoTargets and therapy 2019;12:2861-2868
OncoTargets and therapy 2019;12:2861-2868
Comprehensive Analysis of Expression and Prognostic Value of Sirtuins in Ovarian Cancer.
Sun X, Wang S, Li Q
Frontiers in genetics 2019;10:879
Frontiers in genetics 2019;10:879
Sirtuin-mediated deacetylation of hnRNP A1 suppresses glycolysis and growth in hepatocellular carcinoma.
Yang H, Zhu R, Zhao X, Liu L, Zhou Z, Zhao L, Liang B, Ma W, Zhao J, Liu J, Huang G
Oncogene 2019 Jun;38(25):4915-4931
Oncogene 2019 Jun;38(25):4915-4931
Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.
Wang Z, Chen Z, Jiang Z, Luo P, Liu L, Huang Y, Wang H, Wang Y, Long L, Tan X, Liu D, Jin T, Wang Y, Wang Y, Liao F, Zhang C, Chen L, Gan Y, Liu Y, Yang F, Huang C, Miao H, Chen J, Cheng T, Fu X, Shi C
Nature communications 2019 Jun 10;10(1):2538
Nature communications 2019 Jun 10;10(1):2538
The effect of intervertebral disc degenerative change on biological characteristics of nucleus pulposus mesenchymal stem cell: an in vitro study in rats.
Liu Y, Li Y, Huang ZN, Wang ZY, Nan LP, Wang F, Zhou SF, Wang JC, Feng XM, Zhang L
Connective tissue research 2019 Jul;60(4):376-388
Connective tissue research 2019 Jul;60(4):376-388
Downregulation of SIRT6 by miR-34c-5p is associated with poor prognosis and promotes colon cancer proliferation through inhibiting apoptosis via the JAK2/STAT3 signaling pathway.
Li N, Mao D, Cao Y, Li H, Ren F, Li K
International journal of oncology 2018 May;52(5):1515-1527
International journal of oncology 2018 May;52(5):1515-1527
Autophagy activated by SIRT6 regulates Aβ induced inflammatory response in RPEs.
Feng Y, Liang J, Zhai Y, Sun J, Wang J, She X, Gu Q, Liu Y, Zhu H, Luo X, Sun X
Biochemical and biophysical research communications 2018 Feb 19;496(4):1148-1154
Biochemical and biophysical research communications 2018 Feb 19;496(4):1148-1154
The effect of SIRT6 on the odontoblastic potential of human dental pulp cells.
Sun HL, Wu YR, Huang C, Wang JW, Fu DJ, Liu YC
Journal of endodontics 2014 Mar;40(3):393-8
Journal of endodontics 2014 Mar;40(3):393-8
SIRT6 regulates osteogenic differentiation of rat bone marrow mesenchymal stem cells partially via suppressing the nuclear factor-κB signaling pathway.
Sun H, Wu Y, Fu D, Liu Y, Huang C
Stem cells (Dayton, Ohio) 2014 Jul;32(7):1943-55
Stem cells (Dayton, Ohio) 2014 Jul;32(7):1943-55
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 13572-1-AP(SIRT6 antibody) at dilution of 1:400
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human brain using 13572-1-AP(SIRT6 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SIRT6 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SIRT6. This antibody recognizes human, mouse, rat antigen. The SIRT6 antibody has been validated for the following applications: ELISA, WB, IHC analysis.