13572-1-AP

antibody from Proteintech Group

Targeting: SIRT6

Provider product page for 13572-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [43]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 13572-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#13572-1-AP, RRID:AB_2188915
Product name: SIRT6 antibody
Antibody type: Polyclonal
Description: KD/KO validated SIRT6 antibody (Cat. #13572-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SIRT6 protein structure - 13572-1-AP shown in red.

Submitted references KSHV vIL-6 promotes SIRT3-induced deacetylation of SERBP1 to inhibit ferroptosis and enhance cellular transformation by inducing lipoyltransferase 2 mRNA degradation.

Zhou J, Wang T, Zhang H, Liu J, Wei P, Xu R, Yan Q, Chen G, Li W, Gao SJ, Lu C
PLoS pathogens 2024 Mar;20(3):e1012082

Integrated Transcriptomic and Proteomic Study of the Mechanism of Action of the Novel Small-Molecule Positive Allosteric Modulator 1 in Targeting PAC1-R for the Treatment of D-Gal-Induced Aging Mice.

Liang L, Chen S, Su W, Zhang H, Yu R
International journal of molecular sciences 2024 Mar 30;25(7)

Cardiac injury activates STING signaling via upregulating SIRT6 in macrophages after myocardial infarction.

Kong W, Chen J, Ruan X, Xu X, Li X, Bao M, Shao Y, Bian X, Li R, Jiang Q, Zhang Y, Li Z, Yan F, Ye J
Life sciences 2024 Mar 15;341:122474

Immunoexpression of SIRT1, 6, and 7 in oral leukoplakia and oral squamous cell carcinoma.

Sripodok P, Saito H, Kouketsu A, Takahashi T, Kumamoto H
Odontology 2024 Jan;112(1):221-229

Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy.

Zhou Y, Liu L, Jin B, Wu Y, Xu L, Chang X, Hu L, Wang G, Huang Y, Song L, Zhang T, Wang Y, Xiao Y, Zhang F, Shi M, Liu L, Wang T, Yan R, Guo B
Diabetes 2023 May 1;72(5):611-626

SIRT6 attenuates LPS-induced inflammation and apoptosis of lung epithelial cells in acute lung injury through ACE2/STAT3/PIM1 signaling.

Yang J, Chen X
Immunity, inflammation and disease 2023 Mar;11(3):e809

N(6)-methyladenosine of Spi2a attenuates inflammation and sepsis-associated myocardial dysfunction in mice.

Wang X, Ding Y, Li R, Zhang R, Ge X, Gao R, Wang M, Huang Y, Zhang F, Zhao B, Liao W, Du J
Nature communications 2023 Mar 2;14(1):1185

Xiaojianzhong decoction prevents gastric precancerous lesions in rats by inhibiting autophagy and glycolysis in gastric mucosal cells.

Zhang JX, Bao SC, Chen J, Chen T, Wei HL, Zhou XY, Li JT, Yan SG
World journal of gastrointestinal oncology 2023 Mar 15;15(3):464-489

Caffeic Acid Phenethyl Ester Suppresses Oxidative Stress and Regulates M1/M2 Microglia Polarization via Sirt6/Nrf2 Pathway to Mitigate Cognitive Impairment in Aged Mice following Anesthesia and Surgery.

Wang Y, Cai Z, Zhan G, Li X, Li S, Wang X, Li S, Luo A
Antioxidants (Basel, Switzerland) 2023 Mar 13;12(3)

Pachymic acid modulates sirtuin 6 activity to alleviate lipid metabolism disorders.

Pan ZS, Chen YL, Tang KJ, Liu ZZ, Liang JL, Guan YH, Xin XY, Liu CH, Shen CP
Experimental and therapeutic medicine 2023 Jul;26(1):320

Melatonin inhibits ferroptosis and delays age-related cataract by regulating SIRT6/p-Nrf2/GPX4 and SIRT6/NCOA4/FTH1 pathways.

Mi Y, Wei C, Sun L, Liu H, Zhang J, Luo J, Yu X, He J, Ge H, Liu P
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jan;157:114048

Inhibition of the AKT1/mTOR pathway through SIRT6 over expression downregulated the expression of programmed death-ligand 1 and prolonged overall survival in lung adenocarcinoma.

Yuan ZF, Lin YD, Wu GS, Li L, Yang JP, Zhang JW
Annals of translational medicine 2023 Jan 15;11(1):21

FGF21 alleviates endothelial mitochondrial damage and prevents BBB from disruption after intracranial hemorrhage through a mechanism involving SIRT6.

Wang R, Wang J, Zhang Z, Ma B, Sun S, Gao L, Gao G
Molecular medicine (Cambridge, Mass.) 2023 Dec 4;29(1):165

Microglia Sirt6 modulates the transcriptional activity of NRF2 to ameliorate high-fat diet-induced obesity.

Xiao X, Hu H, Zhong Y, Chen Y, Tang K, Pan Z, Huang J, Yang X, Wang Q, Gao Y
Molecular medicine (Cambridge, Mass.) 2023 Aug 15;29(1):108

Hepatic SIRT6 Modulates Transcriptional Activities of FXR to Alleviate Acetaminophen-induced Hepatotoxicity.

Liu C, Pan Z, Wu Z, Tang K, Zhong Y, Chen Y, Xiao X, Guo J, Duan S, Cui T, Zhong G, Yang Z, Zhong C, Lin S, Gao Y
Cellular and molecular gastroenterology and hepatology 2022;14(2):271-293

SIRT6 Activator UBCS039 Inhibits Thioacetamide-Induced Hepatic Injury In Vitro and In Vivo.

Jiao F, Zhang Z, Hu H, Zhang Y, Xiong Y
Frontiers in pharmacology 2022;13:837544

Reduction of H3K27cr Modification During DNA Damage in Colon Cancer.

Liao M, Chu W, Sun X, Zheng W, Gao S, Li D, Pei D
Frontiers in oncology 2022;12:924061

Selective transportation and energy homeostasis regulation of dietary advanced glycation end-products in human intestinal Caco-2 cells.

Wu Y, Zong M, Zhang Z, Wu Y, Li L, Zhang X, Wu H, Li B
Food chemistry 2022 Oct 15;391:133284

A new FGF1 variant protects against adriamycin-induced cardiotoxicity via modulating p53 activity.

Xiao M, Tang Y, Wang J (a), Lu G, Niu J, Wang J (b), Li J, Liu Q, Wang Z, Huang Z, Guo Y, Gao T, Zhang X, Yue S, Gu J
Redox biology 2022 Feb;49:102219

Total Sesquiterpene Glycosides from Loquat Leaves Ameliorate HFD-Induced Insulin Resistance by Modulating IRS-1/GLUT4, TRPV1, and SIRT6/Nrf2 Signaling Pathways.

Wu R, Jian T, Ding X, Lv H, Meng X, Ren B, Li J, Chen J, Li W
Oxidative medicine and cellular longevity 2021;2021:4706410

Bioinformatics Analysis of the SIRT Family Members and Assessment of Their Potential Clinical Value.

Liu M, Yu J, Jin H, Wang S, Ding J, Xing H, He S, Zeng Y
OncoTargets and therapy 2021;14:2635-2649

Influence of psychostimulants and opioids on epigenetic modification of class III histone deacetylase (HDAC)-sirtuins in glial cells.

Sivalingam K, Doke M, Khan MA, Samikkannu T
Scientific reports 2021 Oct 29;11(1):21335

Exercise ameliorates insulin resistance and improves SIRT6-mediated insulin signaling transduction in liver of obese rats.

Zhang Y, Yang Z, Xu Z, Wan J, Hua T, Sun Q
Canadian journal of physiology and pharmacology 2021 May;99(5):506-511

Sirtuin 6 supra-physiological overexpression in hypothalamic pro-opiomelanocortin neurons promotes obesity via the hypothalamus-adipose axis.

Tang Q, Liu Q, Yang X, Wu T, Huang C, Zhang J, Zhang Z, Zhang G, Zhao Y, Zhou J, Huang H, Xia Y, Yan J, Li Y, He J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Mar;35(3):e21408

Targeting USP47 overcomes tyrosine kinase inhibitor resistance and eradicates leukemia stem/progenitor cells in chronic myelogenous leukemia.

Lei H, Xu HZ, Shan HZ, Liu M, Lu Y, Fang ZX, Jin J, Jing B, Xiao XH, Gao SM, Gao FH, Xia L, Yang L, Liu LG, Wang WW, Liu CX, Tong Y, Wu YZ, Zheng JK, Chen GQ, Zhou L, Wu YL
Nature communications 2021 Jan 4;12(1):51

α-Hederin inhibits the growth of lung cancer A549 cells in vitro and in vivo by decreasing SIRT6 dependent glycolysis.

Fang C, Liu Y, Chen L, Luo Y, Cui Y, Zhang N, Liu P, Zhou M, Xie Y
Pharmaceutical biology 2021 Dec;59(1):11-20

Zhao Y, Bai X, Jia X, Lu Y, Cheng W, Shu M, Zhu Y, Zhu L, Wang L, Shu Y, Song Y, Jin S
BMC geriatrics 2021 Aug 4;21(1):452

Kisspeptin-10 Maintains the Activation of the mTOR Signaling Pathway by Inhibiting SIRT6 to Promote the Synthesis of Milk in Bovine Mammary Epithelial Cells.

Cao Y, Hu G, Zhang Q, Ma L, Wang J, Li W, Ge Y, Cheng J, Yang Z, Fu S, Liu J
Journal of agricultural and food chemistry 2021 Apr 14;69(14):4093-4100

Bone marrow mesenchymal stem cell exosomes suppress phosphate-induced aortic calcification via SIRT6-HMGB1 deacetylation.

Wei W, Guo X, Gu L, Jia J, Yang M, Yuan W, Rong S
Stem cell research & therapy 2021 Apr 13;12(1):235

The SIRT6-Autophagy-Warburg Effect Axis in Papillary Thyroid Cancer.

Yang Z, Huang R, Wei X, Yu W, Min Z, Ye M
Frontiers in oncology 2020;10:1265

The effect of high glucose on the biological characteristics of nucleus pulposus-derived mesenchymal stem cells.

Liu Y, Li Y, Nan LP, Wang F, Zhou SF, Wang JC, Feng XM, Zhang L
Cell biochemistry and function 2020 Mar;38(2):130-140

Associations of sirtuins with clinicopathological variables and prognosis in human ovarian cancer.

He Q, Chen K, Ye R, Dai N, Guo P, Wang L
Oncology letters 2020 Apr;19(4):3278-3288

SIRT6/HIF-1α axis promotes papillary thyroid cancer progression by inducing epithelial-mesenchymal transition.

Yang Z, Yu W, Huang R, Ye M, Min Z
Cancer cell international 2019;19:17

SIRT6 promotes the Warburg effect of papillary thyroid cancer cell BCPAP through reactive oxygen species.

Yu W, Yang Z, Huang R, Min Z, Ye M
OncoTargets and therapy 2019;12:2861-2868

Comprehensive Analysis of Expression and Prognostic Value of Sirtuins in Ovarian Cancer.

Sun X, Wang S, Li Q
Frontiers in genetics 2019;10:879

Sirtuin-mediated deacetylation of hnRNP A1 suppresses glycolysis and growth in hepatocellular carcinoma.

Yang H, Zhu R, Zhao X, Liu L, Zhou Z, Zhao L, Liang B, Ma W, Zhao J, Liu J, Huang G
Oncogene 2019 Jun;38(25):4915-4931

Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.

Wang Z, Chen Z, Jiang Z, Luo P, Liu L, Huang Y, Wang H, Wang Y, Long L, Tan X, Liu D, Jin T, Wang Y, Wang Y, Liao F, Zhang C, Chen L, Gan Y, Liu Y, Yang F, Huang C, Miao H, Chen J, Cheng T, Fu X, Shi C
Nature communications 2019 Jun 10;10(1):2538

The effect of intervertebral disc degenerative change on biological characteristics of nucleus pulposus mesenchymal stem cell: an in vitro study in rats.

Liu Y, Li Y, Huang ZN, Wang ZY, Nan LP, Wang F, Zhou SF, Wang JC, Feng XM, Zhang L
Connective tissue research 2019 Jul;60(4):376-388

Relationship between senescence in macaques and bone marrow mesenchymal stem cells and the molecular mechanism.

Pan XH, Chen YH, Yang YK, Zhang XJ, Lin QK, Li ZA, Cai XM, Pang RQ, Zhu XQ, Ruan GP
Aging 2019 Jan 23;11(2):590-614

Downregulation of SIRT6 by miR-34c-5p is associated with poor prognosis and promotes colon cancer proliferation through inhibiting apoptosis via the JAK2/STAT3 signaling pathway.

Li N, Mao D, Cao Y, Li H, Ren F, Li K
International journal of oncology 2018 May;52(5):1515-1527

Autophagy activated by SIRT6 regulates Aβ induced inflammatory response in RPEs.

Feng Y, Liang J, Zhai Y, Sun J, Wang J, She X, Gu Q, Liu Y, Zhu H, Luo X, Sun X
Biochemical and biophysical research communications 2018 Feb 19;496(4):1148-1154

The effect of SIRT6 on the odontoblastic potential of human dental pulp cells.

Sun HL, Wu YR, Huang C, Wang JW, Fu DJ, Liu YC
Journal of endodontics 2014 Mar;40(3):393-8

SIRT6 regulates osteogenic differentiation of rat bone marrow mesenchymal stem cells partially via suppressing the nuclear factor-κB signaling pathway.

Sun H, Wu Y, Fu D, Liu Y, Huang C
Stem cells (Dayton, Ohio) 2014 Jul;32(7):1943-55

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: human brain tissue were subjected to SDS PAGE followed by western blot with 13572-1-AP(SIRT6 antibody) at dilution of 1:400
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human brain using 13572-1-AP(SIRT6 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The SIRT6 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SIRT6. This antibody recognizes human, mouse, rat antigen. The SIRT6 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 13572-1-AP.pdf

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