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- References [13]
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- Western blot [2]
- Immunohistochemistry [1]
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- Product number
- NB100-2522 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB100-2522, RRID:AB_10003014
- Product name
- Rabbit Polyclonal SIRT6 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Concentration
- 1.0 mg/ml
- Storage
- Store at 4C. Do not freeze.
Submitted references SIRT6 Depletion Sensitizes Human Hepatoma Cells to Chemotherapeutics by Downregulating MDR1 Expression.
Protective effects of SIRT6 against lipopolysaccharide (LPS) are mediated by deacetylation of Ku70.
Deacetylation of Ku70 by SIRT6 attenuates Bax-mediated apoptosis in hepatocellular carcinoma.
SIRT6 Overexpression Potentiates Apoptosis Evasion in Hepatocellular Carcinoma via BCL2-Associated X Protein-Dependent Apoptotic Pathway.
Expression of SIRT2 and SIRT6 in retinoblastoma.
Epigenetic modulation of chronic anxiety and pain by histone deacetylation.
Remote ischemic preconditioning with a specialized protocol activates the non-neuronal cardiac cholinergic system and increases ATP content in the heart.
Biochemical characterization of sirtuin 6 in the brain and its involvement in oxidative stress response.
Putative tumor suppression function of SIRT6 in endometrial cancer.
MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer.
Decreased expression of sirtuin 6 is associated with release of high mobility group box-1 after cerebral ischemia.
The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun.
Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin.
Xia YQ, Hua RJ, Juan C, Zhong ZH, Tao CS, Fang R, Lin H, Rui G, Yong C
Frontiers in pharmacology 2018;9:194
Frontiers in pharmacology 2018;9:194
Protective effects of SIRT6 against lipopolysaccharide (LPS) are mediated by deacetylation of Ku70.
Zhang L, Bai L, Ren Q, Sun G, Si Y
Molecular immunology 2018 Sep;101:312-318
Molecular immunology 2018 Sep;101:312-318
Deacetylation of Ku70 by SIRT6 attenuates Bax-mediated apoptosis in hepatocellular carcinoma.
Tao NN, Ren JH, Tang H, Ran LK, Zhou HZ, Liu B, Huang AL, Chen J
Biochemical and biophysical research communications 2017 Apr 15;485(4):713-719
Biochemical and biophysical research communications 2017 Apr 15;485(4):713-719
SIRT6 Overexpression Potentiates Apoptosis Evasion in Hepatocellular Carcinoma via BCL2-Associated X Protein-Dependent Apoptotic Pathway.
Ran LK, Chen Y, Zhang ZZ, Tao NN, Ren JH, Zhou L, Tang H, Chen X, Chen K, Li WY, Huang AL, Chen J
Clinical cancer research : an official journal of the American Association for Cancer Research 2016 Jul 1;22(13):3372-82
Clinical cancer research : an official journal of the American Association for Cancer Research 2016 Jul 1;22(13):3372-82
Expression of SIRT2 and SIRT6 in retinoblastoma.
Orellana ME, Quezada C, Maloney SC, Antecka E, Balazsi M, Burnier MN Jr
Ophthalmic research 2015;53(2):100-8
Ophthalmic research 2015;53(2):100-8
Epigenetic modulation of chronic anxiety and pain by histone deacetylation.
Tran L, Schulkin J, Ligon CO, Greenwood-Van Meerveld B
Molecular psychiatry 2015 Oct;20(10):1219-31
Molecular psychiatry 2015 Oct;20(10):1219-31
Remote ischemic preconditioning with a specialized protocol activates the non-neuronal cardiac cholinergic system and increases ATP content in the heart.
Oikawa S, Mano A, Takahashi R, Kakinuma Y
International immunopharmacology 2015 Nov;29(1):181-4
International immunopharmacology 2015 Nov;29(1):181-4
Biochemical characterization of sirtuin 6 in the brain and its involvement in oxidative stress response.
Cardinale A, de Stefano MC, Mollinari C, Racaniello M, Garaci E, Merlo D
Neurochemical research 2015 Jan;40(1):59-69
Neurochemical research 2015 Jan;40(1):59-69
Putative tumor suppression function of SIRT6 in endometrial cancer.
Fukuda T, Wada-Hiraike O, Oda K, Tanikawa M, Makii C, Inaba K, Miyasaka A, Miyamoto Y, Yano T, Maeda D, Sasaki T, Kawana K, Fukayama M, Osuga Y, Fujii T
FEBS letters 2015 Aug 4;589(17):2274-81
FEBS letters 2015 Aug 4;589(17):2274-81
MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer.
Thirumurthi U, Shen J, Xia W, LaBaff AM, Wei Y, Li CW, Chang WC, Chen CH, Lin HK, Yu D, Hung MC
Science signaling 2014 Jul 29;7(336):ra71
Science signaling 2014 Jul 29;7(336):ra71
Decreased expression of sirtuin 6 is associated with release of high mobility group box-1 after cerebral ischemia.
Lee OH, Kim J, Kim JM, Lee H, Kim EH, Bae SK, Choi Y, Nam HS, Heo JH
Biochemical and biophysical research communications 2013 Aug 23;438(2):388-94
Biochemical and biophysical research communications 2013 Aug 23;438(2):388-94
The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun.
Sundaresan NR, Vasudevan P, Zhong L, Kim G, Samant S, Parekh V, Pillai VB, Ravindra PV, Gupta M, Jeevanandam V, Cunningham JM, Deng CX, Lombard DB, Mostoslavsky R, Gupta MP
Nature medicine 2012 Nov;18(11):1643-50
Nature medicine 2012 Nov;18(11):1643-50
Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin.
Min L, Ji Y, Bakiri L, Qiu Z, Cen J, Chen X, Chen L, Scheuch H, Zheng H, Qin L, Zatloukal K, Hui L, Wagner EF
Nature cell biology 2012 Nov;14(11):1203-11
Nature cell biology 2012 Nov;14(11):1203-11
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: SIRT6 Antibody [NB100-2522] - WB analysis of SIRT6 in NIH/3T3 cell lysate.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: SIRT6 Antibody [NB100-2522] - AR42J human acinar pancreatic cancer cell line and human Panc-1 cell line lysates. Image from verified customer review.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry: SIRT6 Antibody [NB100-2522] - SIRT6 antibody was tested in mouse testis using DAB with hematoxylin counterstain.
