Antibody data
- Antibody Data
- Antigen structure
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- Product number
- abx117043 - Provider product page
- Provider
- Abbexa
- Product name
- Toll Like Receptor Adaptor Molecule 1 (TICAM1) Antibody
- Antibody type
- Polyclonal
- Description
- TICAM1 Antibody is a Rabbit Polyclonal antibody against TICAM1. Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responsesTLRs recognize conserved motifs found in various pathogens and mediate defense responsesTriggering of the TLR pathway leads to the activation of NF-κB and subsequent regulation of immune and inflammatory genesThe TLRs and members of the IL-1 receptor family share a conserved stretch of approximately 200 amino acids known as the TIR domainUpon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains including MyD88 (myeloid differentiation factor), MAL/TIRAP (MyD88-adaptor-like/TIR-associated protein), TRIF (Toll-receptor-associated activator of interferon), and TRAM (Toll-receptor-associated molecule)This association leads to the recruitment and activation of IRAK1 and IRAK4, which form a complex with TRAF6 to activate TAK1 and IKKActivation of IKK leads to the degradation of IκB that normally maintains NF-κB inactivity by sequestering it in the cytoplasmTRIF (also termed TICAM-1) is a TIR-domain adaptor protein described to activate NF-κB, IRF3 and trigger IFN-β productionStudies using dominant negative forms of TRIF and siRNA targeting TRIF show that TRIF functions downstream of both TLR3 and TLR4 in response to dsRNA and LPS respectivelyTRIF recruits TRAF6-TAK1-TAB2 to the receptor complex which leads to NF-κB activationIn addition, TRIF can trigger signaling of that lead to the induction of apoptosis.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µg
- Storage
- Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
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