CABT-L541

antibody from Creative Diagnostics

Targeting: TNFRSF17 BCM, BCMA, CD269, TNFRSF13A

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

CABT-L541

Provider

Creative Diagnostics

Product name

Rabbit Anti-Human TNFRSF17 polyclonal antibody

Antibody type

Polyclonal

Description

Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL-1/THANK/zTNF4 and April/TALL-2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non-immunological cell growth. Three receptors, BCMA (for B cell maturation protein), TACI, and BAFF-R, for BAFF were recently identified. BCMA, like TACI, binds BAFF and April. BAFF and its receptors induce B cell development and survival, activate NF-kB and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.