Ab130884

antibody from Aladdin Scientific Corporation

Targeting: TGFBR2 MFS2, TBR-ii, TBRII

Western blot (Data presented on provider website)

Antibody Data

Product number

Ab130884

Provider

Aladdin Scientific Corporation

Product name

Recombinant TGF beta Receptor II Antibody

Antibody type

Recombinant

Description

Rabbit anti Human TGF beta Receptor II Antibody, Recombinant (R08-2E3), could be used for WB and so on.Application:WB: 1/500-1/2000Protein FunctionTransmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Antigen sequence

AA 1-150


Antibody clone number

R08-2E3

Vial size

100μl,10μl,1ml,50μl

Concentration

2 mg/ml

Storage

Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.