DCABH-4267

antibody from Creative Diagnostics

Targeting: EIF2AK1 HRI, KIAA1369

Western blot (Recommended by provider)

Antibody Data

Product number

DCABH-4267

Provider

Creative Diagnostics

Proper citation

Creative Diagnostics Cat#DCABH-4267, RRID:AB_2478055

Product name

Rabbit Anti-Human HRI monoclonal antibody, clone 8I4M4

Antibody type

Monoclonal

Description

The protein encoded by this gene acts at the level of translation initiation to downregulate protein synthesis in response to stress. The encoded protein is a kinase that can be inactivated by hemin. Two transcript variants encoding different isoforms have been found for this gene.The HRI gene is localized to 7p22 where its 3' end slightly overlaps the 3' end of the gene JTV1. The two genes are transcribed from opposite strands. Studies in rat and rabbit suggest that the HRI gene product phosphorylates the alpha subunit of eukaryotic initiation factor 2. Its kinase activity is induced by low levels of heme and inhibited by the presence of heme.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

8I4M4

Concentration

0.5 mg/ml

Storage

-20°C, Avoid Freeze/Thaw Cycles