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Learn45-1619-42
antibody from Invitrogen Antibodies
Targeting: KLRB1
CD161, CLEC5B, hNKR-P1A, NKR, NKR-P1, NKR-P1A
Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [12]
- Comments [0]
- Validations
- Flow cytometry [1]
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- Product number
- 45-1619-42 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- CD161 Monoclonal Antibody (HP-3G10), PerCP-Cyanine5.5, eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: This HP-3G10 monoclonal antibody reacts with CD161 (also known as NKR-P1A), a member of the C-type lectin superfamily. The human homologue of NK1.1 in C57BL/6 mice, CD161 is expressed on natural killer cells and is upregulated in response to IL-12. CD161 can also be detected on various T cell subsets, including memory/effector CD4+ T cells, CD8+ T cells, gammadeltaTCR T cells, and a subset of CD3+ thymocytes. Finally, CD161 expression has been demonstrated on human Th17 CD4+ T cells. The function of this receptor is unclear although studies suggest a possible stimulatory role. Nevertheless, Lectin-like transcript-1 (LLT1), which is also known as osteoclast inhibitory lectin, has been identified as the ligand for CD161.
- Antibody clone number
- HP-3G10
- Concentration
- 5 µL/Test
Submitted references A Novel Homozygous Stop Mutation in IL23R Causes Mendelian Susceptibility to Mycobacterial Disease.
Bacillus anthracis lethal toxin negatively modulates ILC3 function through perturbation of IL-23-mediated MAPK signaling.
Inherited GINS1 deficiency underlies growth retardation along with neutropenia and NK cell deficiency.
Regulatory T cells that co-express RORγt and FOXP3 are pro-inflammatory and immunosuppressive and expand in human pancreatic cancer.
Stress-related and homeostatic cytokines regulate Vγ9Vδ2 T-cell surveillance of mevalonate metabolism.
The Peripheral NK Cell Repertoire after Kidney Transplantation is Modulated by Different Immunosuppressive Drugs.
Effect of chronic morphine administration on circulating T cell population dynamics in rhesus macaques.
IL-7 licenses activation of human liver intrasinusoidal mucosal-associated invariant T cells.
A CD8α(-) subpopulation of macaque circulatory natural killer cells can mediate both antibody-dependent and antibody-independent cytotoxic activities.
Functional consequences of interactions between human NKR-P1A and its ligand LLT1 expressed on activated dendritic cells and B cells.
Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor.
Identification of a common developmental pathway for thymic natural killer cells and dendritic cells.
Staels F, Lorenzetti F, De Keukeleere K, Willemsen M, Gerbaux M, Neumann J, Tousseyn T, Pasciuto E, De Munter P, Bossuyt X, Gijsbers R, Liston A, Humblet-Baron S, Schrijvers R
Journal of clinical immunology 2022 Nov;42(8):1638-1652
Journal of clinical immunology 2022 Nov;42(8):1638-1652
Bacillus anthracis lethal toxin negatively modulates ILC3 function through perturbation of IL-23-mediated MAPK signaling.
Seshadri S, Allan DSJ, Carlyle JR, Zenewicz LA
PLoS pathogens 2017 Oct;13(10):e1006690
PLoS pathogens 2017 Oct;13(10):e1006690
Inherited GINS1 deficiency underlies growth retardation along with neutropenia and NK cell deficiency.
Cottineau J, Kottemann MC, Lach FP, Kang YH, Vély F, Deenick EK, Lazarov T, Gineau L, Wang Y, Farina A, Chansel M, Lorenzo L, Piperoglou C, Ma CS, Nitschke P, Belkadi A, Itan Y, Boisson B, Jabot-Hanin F, Picard C, Bustamante J, Eidenschenk C, Boucherit S, Aladjidi N, Lacombe D, Barat P, Qasim W, Hurst JA, Pollard AJ, Uhlig HH, Fieschi C, Michon J, Bermudez VP, Abel L, de Villartay JP, Geissmann F, Tangye SG, Hurwitz J, Vivier E, Casanova JL, Smogorzewska A, Jouanguy E
The Journal of clinical investigation 2017 May 1;127(5):1991-2006
The Journal of clinical investigation 2017 May 1;127(5):1991-2006
Regulatory T cells that co-express RORγt and FOXP3 are pro-inflammatory and immunosuppressive and expand in human pancreatic cancer.
Chellappa S, Hugenschmidt H, Hagness M, Line PD, Labori KJ, Wiedswang G, Taskén K, Aandahl EM
Oncoimmunology 2016 Apr;5(4):e1102828
Oncoimmunology 2016 Apr;5(4):e1102828
Stress-related and homeostatic cytokines regulate Vγ9Vδ2 T-cell surveillance of mevalonate metabolism.
Gruenbacher G, Nussbaumer O, Gander H, Steiner B, Leonhartsberger N, Thurnher M
Oncoimmunology 2014;3(8):e953410
Oncoimmunology 2014;3(8):e953410
The Peripheral NK Cell Repertoire after Kidney Transplantation is Modulated by Different Immunosuppressive Drugs.
Neudoerfl C, Mueller BJ, Blume C, Daemen K, Stevanovic-Meyer M, Keil J, Lehner F, Haller H, Falk CS
Frontiers in immunology 2013;4:46
Frontiers in immunology 2013;4:46
Effect of chronic morphine administration on circulating T cell population dynamics in rhesus macaques.
Cornwell WD, Lewis MG, Fan X, Rappaport J, Rogers TJ
Journal of neuroimmunology 2013 Dec 15;265(1-2):43-50
Journal of neuroimmunology 2013 Dec 15;265(1-2):43-50
IL-7 licenses activation of human liver intrasinusoidal mucosal-associated invariant T cells.
Tang XZ, Jo J, Tan AT, Sandalova E, Chia A, Tan KC, Lee KH, Gehring AJ, De Libero G, Bertoletti A
Journal of immunology (Baltimore, Md. : 1950) 2013 Apr 1;190(7):3142-52
Journal of immunology (Baltimore, Md. : 1950) 2013 Apr 1;190(7):3142-52
A CD8α(-) subpopulation of macaque circulatory natural killer cells can mediate both antibody-dependent and antibody-independent cytotoxic activities.
Vargas-Inchaustegui DA, Demberg T, Robert-Guroff M
Immunology 2011 Nov;134(3):326-40
Immunology 2011 Nov;134(3):326-40
Functional consequences of interactions between human NKR-P1A and its ligand LLT1 expressed on activated dendritic cells and B cells.
Rosen DB, Cao W, Avery DT, Tangye SG, Liu YJ, Houchins JP, Lanier LL
Journal of immunology (Baltimore, Md. : 1950) 2008 May 15;180(10):6508-17
Journal of immunology (Baltimore, Md. : 1950) 2008 May 15;180(10):6508-17
Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor.
Cosmi L, De Palma R, Santarlasci V, Maggi L, Capone M, Frosali F, Rodolico G, Querci V, Abbate G, Angeli R, Berrino L, Fambrini M, Caproni M, Tonelli F, Lazzeri E, Parronchi P, Liotta F, Maggi E, Romagnani S, Annunziato F
The Journal of experimental medicine 2008 Aug 4;205(8):1903-16
The Journal of experimental medicine 2008 Aug 4;205(8):1903-16
Identification of a common developmental pathway for thymic natural killer cells and dendritic cells.
Márquez C, Trigueros C, Franco JM, Ramiro AR, Carrasco YR, López-Botet M, Toribio ML
Blood 1998 Apr 15;91(8):2760-71
Blood 1998 Apr 15;91(8):2760-71
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Supportive validation
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- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Staining of normal human peripheral blood cells with Anti-Human CD4 PE (Product # 12-0048-42) and Mouse IgG1 K Isotype Control PerCP-Cyanine5-5 (Product # 45-4714-82) (left) or Anti-Human CD161 PerCP-Cyanine5-5 (right). Cells in the lymphocyte gate were used for analysis.
