11-4053

antibody from ABEOMICS Inc.
Targeting: OLR1 CLEC8A, LOX-1, SCARE1
Provider product page for 11-4053

Antibody data

Product number
11-4053 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-CLEC8A Antibody
Antibody type
Polyclonal
Description
CLEC8A or OLR1 is a member of C-type lectin super family. It is the receptor that mediates the recognition and degradation of low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in inflammatory responses, pro-oxidative conditions and apoptosis. OLR1 ligation with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, Monocyte adhesion and apoptosis. OLR1 is highly expressed in vascular rich organs, like placenta, liver, lungs and brain. CLEC8A has been reported to be associated with diseases, like atherosclerosis, myocardial infarction and Alzheimer's disease. Alternative splicing produces three isoforms of CLEC8A or OLR1 whose exact function is yet to be ascertained.
Reactivity
Human
Host
Rabbit
Antigen sequence
A partial length recombinant CLEC8A
protein (amino acids 1-200) was us
ed as the immunogen for this antibo
dy.
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freezing and thawing
OLR1 protein structure - 11-4053 shown in red.