ABIN233773

antibody from antibodies-online

Targeting: CUL4A

Western blot (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

ABIN233773

Provider

antibodies-online

Proper citation

Antibodies-Online Cat#ABIN233773, RRID:AB_10784807

Product name

anti-Cullin 4A (CUL4A) (AA 1-20), (N-Term) antibody

Antibody type

Polyclonal

Description

Antiserum

Reactivity

Human

Host

Rabbit

Epitope

N-Term, AA 1-20

Vial size

100 μL

Storage

-20°C

References

Submitted references

DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress.

Leung-Pineda V, Huh J, Piwnica-Worms H
Cancer research 2009 Mar 15;69(6):2630-7

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PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex.

Abbas T, Sivaprasad U, Terai K, Amador V, Pagano M, Dutta A
Genes & development 2008 Sep 15;22(18):2496-506

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CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation.

Nishitani H, Shiomi Y, Iida H, Michishita M, Takami T, Tsurimoto T
The Journal of biological chemistry 2008 Oct 24;283(43):29045-52

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Cul4A targets p27 for degradation and regulates proliferation, cell cycle exit, and differentiation during erythropoiesis.

Li B, Jia N, Kapur R, Chun KT
Blood 2006 Jun 1;107(11):4291-9

Immunohistochemistry

Supportive validation

Submitted by

antibodies-online (provider)

Main image

Experimental details

IHC