BS4370

antibody from Bioworld Technology, Inc
Targeting: WASF1 KIAA0269, SCAR1, WAVE, WAVE1
Provider product page for BS4370
Western blot
Immunohistochemistry

Antibody data

Product number
BS4370 - Provider product page
Provider
Bioworld Technology, Inc
Product name
WAVE1 (phospho Y125) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic phosphopeptide derived from human WAVE1 around the phosphorylation site of Tyrosine 125.
Description
WASP (for Wiskott-Aldrich syndrome protein) and N-WASP are downstream effectors of Cdc42 that are implicated in actin polymerization and cytoskeletal organization. The WASP family also includes VASP (vasodilator-stimulated phosphoprotein) and Mena (for mammalian enabled protein), which accumulate at focal adhesions and are also involved in the regulation of the actin cytoskeleton. The WAVE proteins are related to the WASP family proteins and are likewise involved in mediating actin reorganization downstream of the Rho family of small GTPases. The two protein homologs WAVE1 and WAVE2 specifically regulate membrane ruffling by inducing the formation of actin filament clusters in response to GTP binding and activating Rac. The WAVE proteins mediate this actin polymerization by cooperating with the Arp2/3 complex, a nucleation core, and thereby promoting the formation of actin filaments. WAVE1, which is also designated SCAR (for suppressor of cAR), is expressed primarily in the brain, while WAVE2 is widely expressed with the expression highest in peripheral blood leukocytes.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
WASF1 protein structure - BS4370 shown in red.