CABT-BL8406

antibody from Creative Diagnostics

Targeting: TOX KIAA0808, TOX1

Western blot (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Antibody Data

Product number

CABT-BL8406

Provider

Creative Diagnostics

Product name

Anti-Tox Monoclonal antibody, clone UYSY20

Antibody type

Monoclonal

Description

TOX (thymocyte selection-associated high mobility group (HMG) box protein) is a member of the HMG box family of DNA-binding proteins and likely plays a role in the regulation of T-cell development. It is a 526 amino acid nuclear protein and the expression of TOX is upregulated by pre-T cell receptor (pre-TCR) and TCR activation in immature thymocytes. TOX-mediated positive selection is associated with up-regulation of RUNX3 and is calcineurin dependent. TOX-dependent transition to the CD4+CD8 stage is required for development of class II major histocompatibility complex-specific T cells.

Reactivity

Human, Mouse

Host

Rat

Conjugate

Unconjugated

Isotype

IgG