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- Antibody Data
- Antigen structure
- References [35]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 14007-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14007-1-AP, RRID:AB_2102386
- Product name
- ESR2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated ESR2 antibody (Cat. #14007-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Pan-Cancer Prognostic Role and Targeting Potential of the Estrogen-Progesterone Axis.
Silibinin treatment protects human skin cells from UVB injury through upregulation of estrogen receptors.
Genistein reverses the effect of 17β-estradiol on exacerbating experimental occlusal interference-induced chronic masseter hyperalgesia in ovariectomised rats.
The "Matrisome" reveals the characterization of skin keloid microenvironment.
Psoralen, a natural phytoestrogen, improves diaphyseal fracture healing in ovariectomized mice: A preliminary study.
Wntless (Wls): A Prognostic Index for Progression and Patient Survival of Breast Cancer.
Neuroprotective effects of vitamin D and 17ß-estradiol against ovariectomy-induced neuroinflammation and depressive-like state: Role of the AMPK/NF-κB pathway.
CLPTM1L induces estrogen receptor β signaling-mediated radioresistance in non-small cell lung cancer cells.
Natural flavonoid silibinin promotes the migration and myogenic differentiation of murine C2C12 myoblasts via modulation of ROS generation and down-regulation of estrogen receptor α expression.
The ancient Chinese formula Longdan Xiegan Tang improves antipsychotic-induced hyperprolactinemia by repairing the hypothalamic and pituitary TGF-β1 signaling in rats.
Elevated maternal androgen is associated with dysfunctional placenta and lipid disorder in newborns of mothers with polycystic ovary syndrome.
NLRP3 inflammasome activation by estrogen promotes the progression of human endometrial cancer.
Risk analysis of systemic levels of estrogen and adipokines as well as estrogen receptors from PBMCs in childbearing and perimenopausal women with obesity.
Attenuating effect of silibinin on palmitic acid-induced apoptosis and mitochondrial dysfunction in pancreatic β-cells is mediated by estrogen receptor alpha.
Saikosaponin‑D improves fear memory deficits in ovariectomized rats via the action of estrogen receptor‑α in the hippocampus.
ERβ promotes Aβ degradation via the modulation of autophagy.
Genistein inhibits Ang II-induced CRP and MMP-9 generations via the ER-p38/ERK1/2-PPARγ-NF-κB signaling pathway in rat vascular smooth muscle cells.
Establishment and evaluation of a novel mouse model of peri/postmenopausal depression.
Reversal of increased mammary tumorigenesis by valproic acid and hydralazine in offspring of dams fed high fat diet during pregnancy.
Silibinin protects rat pancreatic β-cell through up-regulation of estrogen receptors' signaling against amylin- or Aβ1-42 -induced reactive oxygen species/reactive nitrogen species generation.
Estrogen receptor β upregulates CCL2 via NF-κB signaling in endometriotic stromal cells and recruits macrophages to promote the pathogenesis of endometriosis.
Rutin attenuates cerebral ischemia-reperfusion injury in ovariectomized rats via estrogen-receptor-mediated BDNF-TrkB and NGF-TrkA signaling.
Involvement of estrogen receptors in silibinin protection of pancreatic β-cells from TNFα- or IL-1β-induced cytotoxicity.
17β-estradiol upregulates IL6 expression through the ERβ pathway to promote lung adenocarcinoma progression.
High glucose impaired estrogen receptor alpha signaling via β-catenin in osteoblastic MC3T3-E1.
Ovarian Clear Cell Carcinoma Sub-Typing by ARID1A Expression.
Estrogen promotes tumor metastasis via estrogen receptor beta-mediated regulation of matrix-metalloproteinase-2 in non-small cell lung cancer.
Developmental expression of estrogen receptor beta in the brain of prairie voles (Microtus ochrogaster).
Differential expression of androgen, estrogen, and progesterone receptors in benign prostatic hyperplasia.
ERβ up-regulation was involved in silibinin-induced growth inhibition of human breast cancer MCF-7 cells.
Alpha-Lipoic Acid Promotes Osteoblastic Formation in H2O2 -Treated MC3T3-E1 Cells and Prevents Bone Loss in Ovariectomized Rats.
Fulvestrant-mediated inhibition of estrogen receptor signaling slows lung cancer progression.
Dioscin promotes osteoblastic proliferation and differentiation via Lrp5 and ER pathway in mouse and human osteoblast-like cell lines.
Estrogen and insulin-like growth factor 1 synergistically promote the development of lung adenocarcinoma in mice.
Estradiol regulates miR-135b and mismatch repair gene expressions via estrogen receptor-β in colorectal cells.
Shen YT, Huang X, Zhang G, Jiang B, Li CJ, Wu ZS
Frontiers in oncology 2021;11:636365
Frontiers in oncology 2021;11:636365
Silibinin treatment protects human skin cells from UVB injury through upregulation of estrogen receptors.
Liu W, Wang F, Li C, Otkur W, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Onodera S, Ikejima T
Journal of photochemistry and photobiology. B, Biology 2021 Mar;216:112147
Journal of photochemistry and photobiology. B, Biology 2021 Mar;216:112147
Genistein reverses the effect of 17β-estradiol on exacerbating experimental occlusal interference-induced chronic masseter hyperalgesia in ovariectomised rats.
Liu Y, Zhang XY, Fan YY, Xu XX, Xie QF
Journal of oral rehabilitation 2021 Jun 2;
Journal of oral rehabilitation 2021 Jun 2;
The "Matrisome" reveals the characterization of skin keloid microenvironment.
Zhang S, Liu B, Wang W, Lv L, Gao D, Chai M, Li M, Wu Z, Zhu Y, Ma J, Leng L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Apr;35(4):e21237
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Apr;35(4):e21237
Psoralen, a natural phytoestrogen, improves diaphyseal fracture healing in ovariectomized mice: A preliminary study.
Huang K, Sun YQ, Chen XF, Tian F, Cheng F, Gong QL, Liu KB
Experimental and therapeutic medicine 2021 Apr;21(4):368
Experimental and therapeutic medicine 2021 Apr;21(4):368
Wntless (Wls): A Prognostic Index for Progression and Patient Survival of Breast Cancer.
Zheng D, Jiang C, Yan N, Miao Y, Wang K, Gao G, Jiao Y, Zhang X, He M, Yang Z
OncoTargets and therapy 2020;13:12649-12659
OncoTargets and therapy 2020;13:12649-12659
Neuroprotective effects of vitamin D and 17ß-estradiol against ovariectomy-induced neuroinflammation and depressive-like state: Role of the AMPK/NF-κB pathway.
Zhang WY, Guo YJ, Wang KY, Chen LM, Jiang P
International immunopharmacology 2020 Sep;86:106734
International immunopharmacology 2020 Sep;86:106734
CLPTM1L induces estrogen receptor β signaling-mediated radioresistance in non-small cell lung cancer cells.
Li H, Che J, Jiang M, Cui M, Feng G, Dong J, Zhang S, Lu L, Liu W, Fan S
Cell communication and signaling : CCS 2020 Sep 17;18(1):152
Cell communication and signaling : CCS 2020 Sep 17;18(1):152
Natural flavonoid silibinin promotes the migration and myogenic differentiation of murine C2C12 myoblasts via modulation of ROS generation and down-regulation of estrogen receptor α expression.
Long X, Gao Y, Liu W, Liu X, Hayashi T, Mizuno K, Hattori S, Ikejima T
Molecular and cellular biochemistry 2020 Nov;474(1-2):243-261
Molecular and cellular biochemistry 2020 Nov;474(1-2):243-261
The ancient Chinese formula Longdan Xiegan Tang improves antipsychotic-induced hyperprolactinemia by repairing the hypothalamic and pituitary TGF-β1 signaling in rats.
Ren L, Liu W, Wang C, Yang Y, Huang X, Wang C, Li Y
Journal of ethnopharmacology 2020 May 23;254:112572
Journal of ethnopharmacology 2020 May 23;254:112572
Elevated maternal androgen is associated with dysfunctional placenta and lipid disorder in newborns of mothers with polycystic ovary syndrome.
Sun M, Sun B, Qiao S, Feng X, Li Y, Zhang S, Lin Y, Hou L
Fertility and sterility 2020 Jun;113(6):1275-1285.e2
Fertility and sterility 2020 Jun;113(6):1275-1285.e2
NLRP3 inflammasome activation by estrogen promotes the progression of human endometrial cancer.
Liu SG, Wu XX, Hua T, Xin XY, Feng DL, Chi SQ, Wang XX, Wang HB
OncoTargets and therapy 2019;12:6927-6936
OncoTargets and therapy 2019;12:6927-6936
Risk analysis of systemic levels of estrogen and adipokines as well as estrogen receptors from PBMCs in childbearing and perimenopausal women with obesity.
Fan H, Chen S, Gao B, Ding S, Zhao Q, Li C, Asakawa T
Diabetes, metabolic syndrome and obesity : targets and therapy 2019;12:1287-1295
Diabetes, metabolic syndrome and obesity : targets and therapy 2019;12:1287-1295
Attenuating effect of silibinin on palmitic acid-induced apoptosis and mitochondrial dysfunction in pancreatic β-cells is mediated by estrogen receptor alpha.
Sun Y, Yang J, Liu W, Yao G, Xu F, Hayashi T, Onodera S, Ikejima T
Molecular and cellular biochemistry 2019 Oct;460(1-2):81-92
Molecular and cellular biochemistry 2019 Oct;460(1-2):81-92
Saikosaponin‑D improves fear memory deficits in ovariectomized rats via the action of estrogen receptor‑α in the hippocampus.
Liu L, Yan J, Ge F, Xu X, Lu J, Shi H, Li S, Zhao Y, Zhang C
Molecular medicine reports 2019 Jul;20(1):332-340
Molecular medicine reports 2019 Jul;20(1):332-340
ERβ promotes Aβ degradation via the modulation of autophagy.
Wei Y, Zhou J, Wu J, Huang J
Cell death & disease 2019 Jul 22;10(8):565
Cell death & disease 2019 Jul 22;10(8):565
Genistein inhibits Ang II-induced CRP and MMP-9 generations via the ER-p38/ERK1/2-PPARγ-NF-κB signaling pathway in rat vascular smooth muscle cells.
Xu L, Liu JT, Li K, Wang SY, Xu S
Life sciences 2019 Jan 1;216:140-146
Life sciences 2019 Jan 1;216:140-146
Establishment and evaluation of a novel mouse model of peri/postmenopausal depression.
Zhang L, Cao LL, Yang DD, Ding JH, Guo XD, Xue TF, Zhao XJ, Sun XL
Heliyon 2019 Feb;5(2):e01195
Heliyon 2019 Feb;5(2):e01195
Reversal of increased mammary tumorigenesis by valproic acid and hydralazine in offspring of dams fed high fat diet during pregnancy.
Andrade FO, Nguyen NM, Warri A, Hilakivi-Clarke L
Scientific reports 2019 Dec 30;9(1):20271
Scientific reports 2019 Dec 30;9(1):20271
Silibinin protects rat pancreatic β-cell through up-regulation of estrogen receptors' signaling against amylin- or Aβ1-42 -induced reactive oxygen species/reactive nitrogen species generation.
Yang J, Sun Y, Xu F, Liu W, Hayashi T, Hattori S, Ushiki-Kaku Y, Onodera S, Tashiro SI, Ikejima T
Phytotherapy research : PTR 2019 Apr;33(4):998-1009
Phytotherapy research : PTR 2019 Apr;33(4):998-1009
Estrogen receptor β upregulates CCL2 via NF-κB signaling in endometriotic stromal cells and recruits macrophages to promote the pathogenesis of endometriosis.
Gou Y, Li X, Li P, Zhang H, Xu T, Wang H, Wang B, Ma X, Jiang X, Zhang Z
Human reproduction (Oxford, England) 2019 Apr 1;34(4):646-658
Human reproduction (Oxford, England) 2019 Apr 1;34(4):646-658
Rutin attenuates cerebral ischemia-reperfusion injury in ovariectomized rats via estrogen-receptor-mediated BDNF-TrkB and NGF-TrkA signaling.
Liu H, Zhong L, Zhang Y, Liu X, Li J
Biochemistry and cell biology = Biochimie et biologie cellulaire 2018 Oct;96(5):672-681
Biochemistry and cell biology = Biochimie et biologie cellulaire 2018 Oct;96(5):672-681
Involvement of estrogen receptors in silibinin protection of pancreatic β-cells from TNFα- or IL-1β-induced cytotoxicity.
Yang J, Sun Y, Xu F, Liu W, Hayashi T, Onodera S, Tashiro SI, Ikejima T
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jun;102:344-353
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jun;102:344-353
17β-estradiol upregulates IL6 expression through the ERβ pathway to promote lung adenocarcinoma progression.
Huang Q, Zhang Z, Liao Y, Liu C, Fan S, Wei X, Ai B, Xiong J
Journal of experimental & clinical cancer research : CR 2018 Jul 3;37(1):133
Journal of experimental & clinical cancer research : CR 2018 Jul 3;37(1):133
High glucose impaired estrogen receptor alpha signaling via β-catenin in osteoblastic MC3T3-E1.
Wang R, Gao D, Zhou Y, Chen L, Luo B, Yu Y, Li H, Hu J, Huang Q, He M, Peng W, Luo D
The Journal of steroid biochemistry and molecular biology 2017 Nov;174:276-283
The Journal of steroid biochemistry and molecular biology 2017 Nov;174:276-283
Ovarian Clear Cell Carcinoma Sub-Typing by ARID1A Expression.
Choi JY, Han HH, Kim YT, Lee JH, Kim BG, Kang S, Cho NH
Yonsei medical journal 2017 Jan;58(1):59-66
Yonsei medical journal 2017 Jan;58(1):59-66
Estrogen promotes tumor metastasis via estrogen receptor beta-mediated regulation of matrix-metalloproteinase-2 in non-small cell lung cancer.
Fan S, Liao Y, Liu C, Huang Q, Liang H, Ai B, Fu S, Zhou S
Oncotarget 2017 Aug 22;8(34):56443-56459
Oncotarget 2017 Aug 22;8(34):56443-56459
Developmental expression of estrogen receptor beta in the brain of prairie voles (Microtus ochrogaster).
Ploskonka SD, Eaton JL, Carr MS, Schmidt JV, Cushing BS
Developmental psychobiology 2016 Mar;58(2):223-30
Developmental psychobiology 2016 Mar;58(2):223-30
Differential expression of androgen, estrogen, and progesterone receptors in benign prostatic hyperplasia.
Song L, Shen W, Zhang H, Wang Q, Wang Y, Zhou Z
Bosnian journal of basic medical sciences 2016 Jul 2;16(3):201-8
Bosnian journal of basic medical sciences 2016 Jul 2;16(3):201-8
ERβ up-regulation was involved in silibinin-induced growth inhibition of human breast cancer MCF-7 cells.
Zheng N, Liu L, Liu W, Zhang P, Huang H, Zang L, Hayashi T, Tashiro S, Onodera S, Xia M, Ikejima T
Archives of biochemistry and biophysics 2016 Feb 1;591:141-9
Archives of biochemistry and biophysics 2016 Feb 1;591:141-9
Alpha-Lipoic Acid Promotes Osteoblastic Formation in H2O2 -Treated MC3T3-E1 Cells and Prevents Bone Loss in Ovariectomized Rats.
Fu C, Xu D, Wang CY, Jin Y, Liu Q, Meng Q, Liu KX, Sun HJ, Liu MZ
Journal of cellular physiology 2015 Sep;230(9):2184-201
Journal of cellular physiology 2015 Sep;230(9):2184-201
Fulvestrant-mediated inhibition of estrogen receptor signaling slows lung cancer progression.
Tang H, Liao Y, Zhang C, Chen G, Xu L, Liu Z, Fu S, Yu L, Zhou S
Oncology research 2014;22(1):13-20
Oncology research 2014;22(1):13-20
Dioscin promotes osteoblastic proliferation and differentiation via Lrp5 and ER pathway in mouse and human osteoblast-like cell lines.
Zhang C, Peng J, Wu S, Jin Y, Xia F, Wang C, Liu K, Sun H, Liu M
Journal of biomedical science 2014 Apr 17;21:30
Journal of biomedical science 2014 Apr 17;21:30
Estrogen and insulin-like growth factor 1 synergistically promote the development of lung adenocarcinoma in mice.
Tang H, Liao Y, Xu L, Zhang C, Liu Z, Deng Y, Jiang Z, Fu S, Chen Z, Zhou S
International journal of cancer 2013 Nov 15;133(10):2473-82
International journal of cancer 2013 Nov 15;133(10):2473-82
Estradiol regulates miR-135b and mismatch repair gene expressions via estrogen receptor-β in colorectal cells.
He YQ, Sheng JQ, Ling XL, Fu L, Jin P, Yen L, Rao J
Experimental & molecular medicine 2012 Dec 31;44(12):723-32
Experimental & molecular medicine 2012 Dec 31;44(12):723-32
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- NIH/3T3 cells were subjected to SDS PAGE followed by western blot with 14007-1-AP(ESR2 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ESR2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ESR2. This antibody recognizes human,mouse,rat antigen. The ESR2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
