ABIN152350

antibody from antibodies-online

Targeting: ESR2 ER-beta, Erb, NR3A2

Provider product page for ABIN152350

Western blot

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Chromatin Immunoprecipitation

Antibody data

Antibody Data
Antigen structure
References [75]
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Validations
Western blot [1]
Immunohistochemistry [3]

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Product number: ABIN152350 - Provider product page
Provider: antibodies-online
Product name: anti-Estrogen Receptor 2 (ER Beta) (ESR2) antibody
Antibody type: Monoclonal
Description: Protein G purified
Reactivity: Human, Mouse, Simian
Host: Mouse
Isotype: IgG
Antibody clone number: 14C8
Vial size: 100 μL
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Handling: Avoid freeze-thaw cycles

ESR2 protein structure - ABIN152350 shown in red.

Submitted references Morphometry of paravaginal ganglia from the pelvic plexus: impact of multiparity, primiparity, and pregnancy.

Castelán F, Xelhuantzi N, Hernández-Aragón LG, Rodríguez-Antolín J, Cuevas E, Martínez-Gómez M
European journal of obstetrics, gynecology, and reproductive biology 2013 Sep;170(1):286-92

Ductal carcinoma of the prostate shows a different immunophenotype from high grade acinar cancer.

Jardel P, Debiais C, Godet J, Irani J, Fromont G
Histopathology 2013 Jul;63(1):57-63

Estrogen receptor-β expression and pharmacological targeting in bladder cancer.

Kauffman EC, Robinson BD, Downes M, Marcinkiewicz K, Vourganti S, Scherr DS, Gudas LJ, Mongan NP
Oncology reports 2013 Jul;30(1):131-8

Effect of multiparity on morphometry and oestrogen receptor expression of pelvic and perineal striated muscles in rabbits: is serum oestradiol relevant?

López-García K, E Cuevas, Corona-Quintanilla DL, Jiménez-Estrada I, Martínez-Gómez M, Castelán F
European journal of obstetrics, gynecology, and reproductive biology 2013 Jul;169(1):113-20

PKCα and ERβ Are Associated with Triple-Negative Breast Cancers in African American and Caucasian Patients.

Tonetti DA, Gao W, Escarzaga D, Walters K, Szafran A, Coon JS
International journal of breast cancer 2012;2012:740353

Co-expression of estrogen receptor beta and aromatase in Japanese lung cancer patients: gender-dependent clinical outcome.

Verma MK, Miki Y, Abe K, Nagasaki S, Niikawa H, Suzuki S, Kondo T, Sasano H
Life sciences 2012 Oct 22;91(15-16):800-8

Sase T, Suzuki T, Miura K, Shiiba K, Sato I, Nakamura Y, Takagi K, Onodera Y, Miki Y, Watanabe M, Ishida K, Ohnuma S, Sasaki H, Sato R, Karasawa H, Shibata C, Unno M, Sasaki I, Sasano H
International journal of cancer 2012 Nov 15;131(10):2284-93

Cytoplasmic estrogen receptor β as a potential marker in human non-small cell lung carcinoma.

Verma MK, Miki Y, Abe K, Niikawa H, Sasano H
Expert opinion on therapeutic targets 2012 Mar;16 Suppl 1:S91-102

Differential role of estrogen receptor beta in early versus metastatic non-small cell lung cancer.

Navaratnam S, Skliris G, Qing G, Banerji S, Badiani K, Tu D, Bradbury PA, Leighl NB, Shepherd FA, Nowatzki J, Demers A, Murphy L
Hormones & cancer 2012 Jun;3(3):93-100

Oestrogen receptor β in NSCLC - prevalence, proliferative influence, prognostic impact and smoking.

Karlsson C, Helenius G, Fernandes O, Karlsson MG
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2012 Jun;120(6):451-8

Estrogen receptor α and β in esophageal squamous cell carcinoma.

Zuguchi M, Miki Y, Onodera Y, Fujishima F, Takeyama D, Okamoto H, Miyata G, Sato A, Satomi S, Sasano H
Cancer science 2012 Jul;103(7):1348-55

Aromatase in colon carcinoma.

Sato R, Suzuki T, Katayose Y, Miura K, Shiiba K, Miki Y, Kamogawa Y, Yamamoto K, Takayuki 2nd, Egawa S, Unno M, Sasano H
Anticancer research 2012 Aug;32(8):3069-75

PES1 promotes breast cancer by differentially regulating ERα and ERβ.

Cheng L, Li J, Han Y, Lin J, Niu C, Zhou Z, Yuan B, Huang K, Li J, Jiang K, Zhang H, Ding L, Xu X, Ye Q
The Journal of clinical investigation 2012 Aug;122(8):2857-70

CD133+ cancer stem cell-like cells derived from uterine carcinosarcoma (malignant mixed Müllerian tumor).

Choijamts B, Jimi S, Kondo T, Naganuma Y, Matsumoto T, Kuroki M, Iwasaki H, Emoto M
Stem cells (Dayton, Ohio) 2011 Oct;29(10):1485-95

Estrogen receptor β causes a G2 cell cycle arrest by inhibiting CDK1 activity through the regulation of cyclin B1, GADD45A, and BTG2.

Paruthiyil S, Cvoro A, Tagliaferri M, Cohen I, Shtivelman E, Leitman DC
Breast cancer research and treatment 2011 Oct;129(3):777-84

Sex steroid hormones in pairs of tumor and serum from breast cancer patients and pathobiological role of androstene-3β, 17β-diol.

Honma N, Saji S, Hirose M, Horiguchi S, Kuroi K, Hayashi S, Utsumi T, Harada N
Cancer science 2011 Oct;102(10):1848-54

Estrogen and progesterone receptor isoform distribution through the menstrual cycle in uteri with and without adenomyosis.

Mehasseb MK, Panchal R, Taylor AH, Brown L, Bell SC, Habiba M
Fertility and sterility 2011 Jun;95(7):2228-35, 2235.e1

Novel estrogen-related genes and potential biomarkers of ovarian endometriosis identified by differential expression analysis.

Vouk K, Smuc T, Guggenberger C, Ribič-Pucelj M, Sinkovec J, Husen B, Thole H, Houba P, Thaete C, Adamski J, Rižner TL
The Journal of steroid biochemistry and molecular biology 2011 Jul;125(3-5):231-42

Suppression of estrogen actions in human lung cancer.

Miki Y, Abe K, Suzuki S, Suzuki T, Sasano H
Molecular and cellular endocrinology 2011 Jul 4;340(2):168-74

Co-expression of GPR30 and ERbeta and their association with disease progression in uterine carcinosarcoma.

Huang GS, Gunter MJ, Arend RC, Li M, Arias-Pulido H, Prossnitz ER, Goldberg GL, Smith HO
American journal of obstetrics and gynecology 2010 Sep;203(3):242.e1-5

Steroid receptors, HER2/neu and Ki-67, in endometrioid type of endometrial carcinoma: Correlation with conventional histomorphological features of prognosis.

Chakravarty D, Gupta N, Goda JS, Srinivasan R, Patel FD, Dhaliwal L
Acta histochemica 2010 Jul;112(4):355-63

Estrogen receptor beta binds to and regulates three distinct classes of target genes.

Vivar OI, Zhao X, Saunier EF, Griffin C, Mayba OS, Tagliaferri M, Cohen I, Speed TP, Leitman DC
The Journal of biological chemistry 2010 Jul 16;285(29):22059-66

Highly concordant coexpression of aromatase and estrogen receptor beta in non-small cell lung cancer.

Abe K, Miki Y, Ono K, Mori M, Kakinuma H, Kou Y, Kudo N, Koguchi M, Niikawa H, Suzuki S, Evans DB, Sugawara S, Suzuki T, Sasano H
Human pathology 2010 Feb;41(2):190-8

Repression of estrogen receptor beta function by putative tumor suppressor DBC1.

Koyama S, Wada-Hiraike O, Nakagawa S, Tanikawa M, Hiraike H, Miyamoto Y, Sone K, Oda K, Fukuhara H, Nakagawa K, Kato S, Yano T, Taketani Y
Biochemical and biophysical research communications 2010 Feb 12;392(3):357-62

Selective activation of estrogen receptor-beta target genes by 3,3'-diindolylmethane.

Vivar OI, Saunier EF, Leitman DC, Firestone GL, Bjeldanes LF
Endocrinology 2010 Apr;151(4):1662-7

ERbeta impedes prostate cancer EMT by destabilizing HIF-1alpha and inhibiting VEGF-mediated snail nuclear localization: implications for Gleason grading.

Mak P, Leav I, Pursell B, Bae D, Yang X, Taglienti CA, Gouvin LM, Sharma VM, Mercurio AM
Cancer cell 2010 Apr 13;17(4):319-32

Oestrogen receptor beta expression in pleomorphic adenomas of the parotid gland.

Wong MH, Dobbins TA, Tseung J, Tran N, Lee CS, O'Brien CJ, Clark J, Rose BR
Journal of clinical pathology 2009 Sep;62(9):789-93

Estrogen receptor beta--an independent prognostic marker in estrogen receptor alpha and progesterone receptor-positive breast cancer?

Maehle BO, Collett K, Tretli S, Akslen LA, Grotmol T
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2009 Sep;117(9):644-50

Immunohistochemical expression of estrogen and progesterone receptors identifies a subset of NSCLCs and correlates with EGFR mutation.

Raso MG, Behrens C, Herynk MH, Liu S, Prudkin L, Ozburn NC, Woods DM, Tang X, Mehran RJ, Moran C, Lee JJ, Wistuba II
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Sep 1;15(17):5359-68

Estrogen receptor beta-mediated nuclear interaction between IRS-1 and Rad51 inhibits homologous recombination directed DNA repair in medulloblastoma.

Urbanska K, Pannizzo P, Lassak A, Gualco E, Surmacz E, Croul S, Del Valle L, Khalili K, Reiss K
Journal of cellular physiology 2009 May;219(2):392-401

Blockade of estrogen receptor signaling inhibits growth and migration of medulloblastoma.

Belcher SM, Ma X, Le HH
Endocrinology 2009 Mar;150(3):1112-21

Comparative effects of raloxifene, tamoxifen and estradiol on human osteoblasts in vitro: estrogen receptor dependent or independent pathways of raloxifene.

Miki Y, Suzuki T, Nagasaki S, Hata S, Akahira J, Sasano H
The Journal of steroid biochemistry and molecular biology 2009 Feb;113(3-5):281-9

Steroid sulfatase and estrogen sulfotransferase in colon carcinoma: regulators of intratumoral estrogen concentrations and potent prognostic factors.

Sato R, Suzuki T, Katayose Y, Miura K, Shiiba K, Tateno H, Miki Y, Akahira J, Kamogawa Y, Nagasaki S, Yamamoto K, Ii T, Egawa S, Evans DB, Unno M, Sasano H
Cancer research 2009 Feb 1;69(3):914-22

Tissue microarray analysis of hormonal signaling pathways in uterine carcinosarcoma.

Huang GS, Arend RC, Li M, Gunter MJ, Chiu LG, Horwitz SB, Goldberg GL
American journal of obstetrics and gynecology 2009 Apr;200(4):457.e1-5

Sex steroid receptors expression and hormone-induced cell proliferation in human osteosarcoma.

Dohi O, Hatori M, Suzuki T, Ono K, Hosaka M, Akahira J, Miki Y, Nagasaki S, Itoi E, Sasano H
Cancer science 2008 Mar;99(3):518-23

Inflammatory status influences aromatase and steroid receptor expression in endometriosis.

Bukulmez O, Hardy DB, Carr BR, Word RA, Mendelson CR
Endocrinology 2008 Mar;149(3):1190-204

Estrogen-dependent signaling in a molecularly distinct subclass of aggressive prostate cancer.

Setlur SR, Mertz KD, Hoshida Y, Demichelis F, Lupien M, Perner S, Sboner A, Pawitan Y, Andrén O, Johnson LA, Tang J, Adami HO, Calza S, Chinnaiyan AM, Rhodes D, Tomlins S, Fall K, Mucci LA, Kantoff PW, Stampfer MJ, Andersson SO, Varenhorst E, Johansson JE, Brown M, Golub TR, Rubin MA
Journal of the National Cancer Institute 2008 Jun 4;100(11):815-25

Estrogen receptor beta (ERbeta) in endometrial simple hyperplasia and endometrioid carcinoma.

Chakravarty D, Srinivasan R, Ghosh S, Rajwanshi A, Gopalan S
Applied immunohistochemistry & molecular morphology : AIMM 2008 Dec;16(6):535-42

Expression of estrogen receptor beta in normal skin, melanocytic nevi and malignant melanomas.

Ohata C, Tadokoro T, Itami S
The Journal of dermatology 2008 Apr;35(4):215-21

Role of ERbeta palmitoylation in the inhibition of human colon cancer cell proliferation.

Galluzzo P, Caiazza F, Moreno S, Marino M
Endocrine-related cancer 2007 Mar;14(1):153-67

Estrogen receptor-beta regulates psoriasin (S100A7) in human breast cancer.

Skliris GP, Lewis A, Emberley E, Peng B, Weebadda WK, Kemp A, Davie JR, Shiu RP, Watson PH, Murphy LC
Breast cancer research and treatment 2007 Jul;104(1):75-85

17Beta-estradiol induces ERbeta up-regulation via p38/MAPK activation in colon cancer cells.

Caiazza F, Galluzzo P, Lorenzetti S, Marino M
Biochemical and biophysical research communications 2007 Jul 20;359(1):102-7

Protein kinase A exhibits selective modulation of estradiol-dependent transcription in breast cancer cells that is associated with decreased ligand binding, altered estrogen receptor alpha promoter interaction, and changes in receptor phosphorylation.

Al-Dhaheri MH, Rowan BG
Molecular endocrinology (Baltimore, Md.) 2007 Feb;21(2):439-56

Selective activation of estrogen receptor-beta transcriptional pathways by an herbal extract.

Cvoro A, Paruthiyil S, Jones JO, Tzagarakis-Foster C, Clegg NJ, Tatomer D, Medina RT, Tagliaferri M, Schaufele F, Scanlan TS, Diamond MI, Cohen I, Leitman DC
Endocrinology 2007 Feb;148(2):538-47

Estrogen receptor beta expression is associated with tamoxifen response in ERalpha-negative breast carcinoma.

Gruvberger-Saal SK, Bendahl PO, Saal LH, Laakso M, Hegardt C, Edén P, Peterson C, Malmström P, Isola J, Borg A, Fernö M
Clinical cancer research : an official journal of the American Association for Cancer Research 2007 Apr 1;13(7):1987-94

Expression of oestrogen receptor-beta in oestrogen receptor-alpha negative human breast tumours.

Skliris GP, Leygue E, Curtis-Snell L, Watson PH, Murphy LC
British journal of cancer 2006 Sep 4;95(5):616-26

Estrogen receptor-beta is the predominant estrogen receptor subtype in normal human synovia.

Dietrich W, Haitel A, Holzer G, Huber JC, Kolbus A, Tschugguel W
Journal of the Society for Gynecologic Investigation 2006 Oct;13(7):512-7

Matrix metalloproteinase 26 proteolysis of the NH2-terminal domain of the estrogen receptor beta correlates with the survival of breast cancer patients.

Savinov AY, Remacle AG, Golubkov VS, Krajewska M, Kennedy S, Duffy MJ, Rozanov DV, Krajewski S, Strongin AY
Cancer research 2006 Mar 1;66(5):2716-24

Distinct roles of unliganded and liganded estrogen receptors in transcriptional repression.

Cvoro A, Tzagarakis-Foster C, Tatomer D, Paruthiyil S, Fox MS, Leitman DC
Molecular cell 2006 Feb 17;21(4):555-64

Rapid estrogen-induced phosphorylation of the SRC-3 coactivator occurs in an extranuclear complex containing estrogen receptor.

Zheng FF, Wu RC, Smith CL, O'Malley BW
Molecular and cellular biology 2005 Sep;25(18):8273-84

Estrogen receptors alfa (ERalpha) and beta (ERbeta) differentially regulate proliferation and apoptosis of the normal murine mammary epithelial cell line HC11.

Helguero LA, Faulds MH, Gustafsson JA, Haldosén LA
Oncogene 2005 Oct 6;24(44):6605-16

Estrogen receptor alpha-negative breast cancer tissues express significant levels of estrogen-independent transcription factors, ERbeta1 and ERbeta5: potential molecular targets for chemoprevention.

Poola I, Fuqua SA, De Witty RL, Abraham J, Marshallack JJ, Liu A
Clinical cancer research : an official journal of the American Association for Cancer Research 2005 Oct 15;11(20):7579-85

Nuclear estrogen receptor beta in lung cancer: expression and survival differences by sex.

Schwartz AG, Prysak GM, Murphy V, Lonardo F, Pass H, Schwartz J, Brooks S
Clinical cancer research : an official journal of the American Association for Cancer Research 2005 Oct 15;11(20):7280-7

Promotion of mammary cancer development by tamoxifen in a mouse model of Brca1-mutation-related breast cancer.

Jones LP, Li M, Halama ED, Ma Y, Lubet R, Grubbs CJ, Deng CX, Rosen EM, Furth PA
Oncogene 2005 May 19;24(22):3554-62

Progesterone receptor in non-small cell lung cancer--a potent prognostic factor and possible target for endocrine therapy.

Ishibashi H, Suzuki T, Suzuki S, Niikawa H, Lu L, Miki Y, Moriya T, Hayashi S, Handa M, Kondo T, Sasano H
Cancer research 2005 Jul 15;65(14):6450-8

Estrogen receptors beta4 and beta5 are full length functionally distinct ERbeta isoforms: cloning from human ovary and functional characterization.

Poola I, Abraham J, Baldwin K, Saunders A, Bhatnagar R
Endocrine 2005 Aug;27(3):227-38

Analysis of gene expression induced by diethylstilbestrol (DES) in human primitive Mullerian duct cells using microarray.

Miki Y, Suzuki T, Tazawa C, Ishizuka M, Semba S, Gorai I, Sasano H
Cancer letters 2005 Apr 8;220(2):197-210

Low levels of estrogen receptor beta protein predict resistance to tamoxifen therapy in breast cancer.

Hopp TA, Weiss HL, Parra IS, Cui Y, Osborne CK, Fuqua SA
Clinical cancer research : an official journal of the American Association for Cancer Research 2004 Nov 15;10(22):7490-9

Oestrogen receptor beta: what it means for patients with breast cancer.

Speirs V, Carder PJ, Lane S, Dodwell D, Lansdown MR, Hanby AM
The Lancet. Oncology 2004 Mar;5(3):174-81

Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta.

Tee MK, Rogatsky I, Tzagarakis-Foster C, Cvoro A, An J, Christy RJ, Yamamoto KR, Leitman DC
Molecular biology of the cell 2004 Mar;15(3):1262-72

Estrogen receptor alpha and beta profiling in human breast cancer.

Balfe P, McCann A, McGoldrick A, McAllister K, Kennedy M, Dervan P, Kerin MJ
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 2004 Jun;30(5):469-74

Estrogen receptor beta inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrest.

Paruthiyil S, Parmar H, Kerekatte V, Cunha GR, Firestone GL, Leitman DC
Cancer research 2004 Jan 1;64(1):423-8

Stable transfection of an estrogen receptor beta cDNA isoform into MDA-MB-231 breast cancer cells.

Tonetti DA, Rubenstein R, DeLeon M, Zhao H, Pappas SG, Bentrem DJ, Chen B, Constantinou A, Craig Jordan V
The Journal of steroid biochemistry and molecular biology 2003 Oct;87(1):47-55

Expression of estrogen receptors alpha and beta in soft tissue sarcomas: Immunohistochemical and molecular analysis.

Li XQ, Hisaoka M, Hashimoto H
Pathology international 2003 Oct;53(10):671-9

Reduced expression of oestrogen receptor beta in invasive breast cancer and its re-expression using DNA methyl transferase inhibitors in a cell line model.

Skliris GP, Munot K, Bell SM, Carder PJ, Lane S, Horgan K, Lansdown MR, Parkes AT, Hanby AM, Markham AF, Speirs V
The Journal of pathology 2003 Oct;201(2):213-20

Estrogen receptor beta protein in human breast cancer: correlation with clinical tumor parameters.

Fuqua SA, Schiff R, Parra I, Moore JT, Mohsin SK, Osborne CK, Clark GM, Allred DC
Cancer research 2003 May 15;63(10):2434-9

Expression of ERalpha and ERbeta in prostate cancer.

Linja MJ, Savinainen KJ, Tammela TL, Isola JJ, Visakorpi T
The Prostate 2003 May 15;55(3):180-6

Estrogen receptor (ER) beta1 and ERbetacx/beta2 inhibit ERalpha function differently in breast cancer cell line MCF7.

Omoto Y, Eguchi H, Yamamoto-Yamaguchi Y, Hayashi S
Oncogene 2003 Aug 7;22(32):5011-20

Expression of estrogen receptor (ER) (beta)cx protein in ER(alpha)-positive breast cancer: specific correlation with progesterone receptor.

Saji S, Omoto Y, Shimizu C, Warner M, Hayashi Y, Horiguchi S, Watanabe T, Hayashi S, Gustafsson JA, Toi M
Cancer research 2002 Sep 1;62(17):4849-53

Distinct expression patterns of ER alpha and ER beta in normal human mammary gland.

Speirs V, Skliris GP, Burdall SE, Carder PJ
Journal of clinical pathology 2002 May;55(5):371-4

Evaluation of seven oestrogen receptor beta antibodies for immunohistochemistry, western blotting, and flow cytometry in human breast tissue.

Skliris GP, Parkes AT, Limer JL, Burdall SE, Carder PJ, Speirs V
The Journal of pathology 2002 Jun;197(2):155-62

Immunohistochemical detection of ERbeta in breast cancer: towards more detailed receptor profiling?

Skliris GP, Carder PJ, Lansdown MR, Speirs V
British journal of cancer 2001 Apr 20;84(8):1095-8

Altered expression of estrogen receptor-alpha variant messenger RNAs between adjacent normal breast and breast tumor tissues.

Leygue E, Dotzlaw H, Watson PH, Murphy LC
Breast cancer research : BCR 2000;2(1):64-72

Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta.

Kuiper GG, Carlsson B, Grandien K, Enmark E, Häggblad J, Nilsson S, Gustafsson JA
Endocrinology 1997 Mar;138(3):863-70

Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta.

Kuiper GG, Carlsson B, Grandien K, Enmark E, Häggblad J, Nilsson S, Gustafsson JA
Endocrinology 1997 Mar;138(3):863-70

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Supportive validation

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Experimental details: WB

Supportive validation

Submitted by: antibodies-online (provider)
Main image
Experimental details: IHC

Supportive validation

Submitted by: antibodies-online (provider)
Main image
Experimental details: IHC

Supportive validation

Submitted by: antibodies-online (provider)
Main image
Experimental details: IHC