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- Antibody Data
- Antigen structure
- References [5]
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- Product number
- MAB664 - Provider product page
- Provider
- R&D Systems
- Product name
- Human LIGHT/TNFSF14 Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from ascites. Detects human LIGHT/TNFSF14 in ELISAs. In sandwich immunoassays, no significant cross-reactivity or interference with recombinant human (rh) Fas Ligand, rhAPRIL, recombinant mouse TRANCE, rhTNF-alpha or rhTRAIL is observed.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Antigen sequence
O43557- Isotype
- IgG
- Antibody clone number
- 115520
- Vial size
- 500 ug
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Licensed human natural killer cells aid dendritic cell maturation via TNFSF14/LIGHT.
4-1BBL induces TNF receptor-associated factor 1-dependent Bim modulation in human T cells and is a critical component in the costimulation-dependent rescue of functionally impaired HIV-specific CD8 T cells.
4-1BBL induces TNF receptor-associated factor 1-dependent Bim modulation in human T cells and is a critical component in the costimulation-dependent rescue of functionally impaired HIV-specific CD8 T cells.
LIGHT up-regulated on B lymphocytes and monocytes in rheumatoid arthritis mediates cellular adhesion and metalloproteinase production by synoviocytes.
Platelet-derived LIGHT induces inflammatory responses in endothelial cells and monocytes.
Holmes TD, Wilson EB, Black EV, Benest AV, Vaz C, Tan B, Tanavde VM, Cook GP
Proceedings of the National Academy of Sciences of the United States of America 2014 Dec 30;111(52):E5688-96
Proceedings of the National Academy of Sciences of the United States of America 2014 Dec 30;111(52):E5688-96
4-1BBL induces TNF receptor-associated factor 1-dependent Bim modulation in human T cells and is a critical component in the costimulation-dependent rescue of functionally impaired HIV-specific CD8 T cells.
Wang C, Wen T, Routy JP, Bernard NF, Sekaly RP, Watts TH
Journal of immunology (Baltimore, Md. : 1950) 2007 Dec 15;179(12):8252-63
Journal of immunology (Baltimore, Md. : 1950) 2007 Dec 15;179(12):8252-63
4-1BBL induces TNF receptor-associated factor 1-dependent Bim modulation in human T cells and is a critical component in the costimulation-dependent rescue of functionally impaired HIV-specific CD8 T cells.
Wang C, Wen T, Routy JP, Bernard NF, Sekaly RP, Watts TH
Journal of immunology (Baltimore, Md. : 1950) 2007 Dec 15;179(12):8252-63
Journal of immunology (Baltimore, Md. : 1950) 2007 Dec 15;179(12):8252-63
LIGHT up-regulated on B lymphocytes and monocytes in rheumatoid arthritis mediates cellular adhesion and metalloproteinase production by synoviocytes.
Kang YM, Kim SY, Kang JH, Han SW, Nam EJ, Kyung HS, Park JY, Kim IS
Arthritis and rheumatism 2007 Apr;56(4):1106-17
Arthritis and rheumatism 2007 Apr;56(4):1106-17
Platelet-derived LIGHT induces inflammatory responses in endothelial cells and monocytes.
Otterdal K, Smith C, Oie E, Pedersen TM, Yndestad A, Stang E, Endresen K, Solum NO, Aukrust P, Damås JK
Blood 2006 Aug 1;108(3):928-35
Blood 2006 Aug 1;108(3):928-35
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