TNFSF13

The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]

Description

TNF superfamily member 13

Tissue specificity

Tissue enhanced (salivary gland)

Predicted location

Intracellular, Secreted to blood

Protein family

Cancer-related genes
CD markers
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Chromosome

17 (7558292 - 7561608)

Ensembl ID

ENSG00000161955  (ver. 103.38)

Orthologs

Mouse Tnfsf13: ENSMUSG00000089669

UniProt

O75888

neXtProt

NX_O75888

Human splice variants
Mouse splice variants

Protein structure