Ab121877

antibody from Aladdin Scientific Corporation

Targeting: PIM1 PIM

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

Ab121877

Provider

Aladdin Scientific Corporation

Product name

Recombinant PIM1 Antibody

Antibody type

Recombinant

Description

Rabbit anti Human PIM1 Antibody, Recombinant (R08-8D5), could be used for WB, IHC and so on.Application:WB: 1/500-1/1000IHC: 1/50-1/100Protein Function:May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Isoform 2 promotes the G1/S transition of the cell cycle via up-regulation of CDK2 activity and phosphorylation of CDKN1B, resulting in enhanced nuclear export and proteasome-dependent degradation of CDKN1B. Isoform 2 also represses CDKN1B transcription by phosphorylating and inactivating the transcription factor FOXO3. Plays a role in signal transduction in blood cells. Contributes to both cell proliferation and survival and thus provides a selective advantage in tumorigenesis.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Antigen sequence

AA 118-131


Antibody clone number

R08-8D5

Vial size

100μl,10μl,1ml,50μl

Concentration

0,3 mg/ml

Storage

Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.