bs-0081R

antibody from Bioss

Targeting: CASP3 apopain, CPP32, CPP32B, Yama

Provider product page for bs-0081R

Western blot

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [67]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [3]

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Product number: bs-0081R - Provider product page
Provider: Bioss
Proper citation: Bioss Cat#bs-0081R, RRID:AB_10857652
Product name: Caspase 3 Polyclonal Antibody
Antibody type: Polyclonal
Description: KLH conjugated synthetic peptide derived from human Caspase 3(Active)
Reactivity: Human, Mouse, Rat, Bovine, Goat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 100ul
Concentration: 1ug/ul
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

CASP3 protein structure - bs-0081R shown in red.

Submitted references NFAT5 is Regulated by p53/miR-27a Signal Axis and Promotes Mouse Ovarian Granulosa Cells Proliferation.

Tao H, Xiong Q, Ji Z, Zhang F, Liu Y, Chen M
International journal of biological sciences 2019;15(2):287-297

Lung injury after asphyxia and hemorrhagic shock in newborn piglets: Analysis of structural and inflammatory changes.

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Gao XX, Zhang QF, Zhu M, Li XH, Guo YX, Pang J, Liu ZF, You PH, Zhang GM, Wang F
Theriogenology 2019 Oct 15;138:137-144

PURB is a positive regulator of amino acid-induced milk synthesis in bovine mammary epithelial cells.

Huo N, Yu M, Li X, Zhou C, Jin X, Gao X
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Ultrasensitive electrochemiluminescence immunosensor for the transcriptional co-activator p300 by using a graphene oxide monolayer and tetrahedral DNA-mediated signal amplification.

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The Science of the total environment 2019 May 15;665:153-161

Exosome secreted from adipose-derived stem cells attenuates diabetic nephropathy by promoting autophagy flux and inhibiting apoptosis in podocyte.

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Polychlorinated Biphenyl Quinone Induces Caspase 1-Mediated Pyroptosis through Induction of Pro-inflammatory HMGB1-TLR4-NLRP3-GSDMD Signal Axis.

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Pigment epithelium-derived factor peptide promotes limbal stem cell proliferation through hedgehog pathway.

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Strategy for hypertrophic scar therapy: Improved delivery of triamcinolone acetonide using mechanically robust tip-concentrated dissolving microneedle array.

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Effect of recombinant Trichinella spiralis cysteine proteinase inhibitor on TNBS-induced experimental inflammatory bowel disease in mice.

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Comparative Evaluation of the Book-Type Acellular Bone Scaffold and Fibrocartilage Scaffold for Bone-Tendon Healing.

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Desumoylating Isopeptidase 2 (DESI2) Inhibits Proliferation and Promotes Apoptosis of Pancreatic Cancer Cells through Regulating PI3K/AKT/mTOR Signaling Pathway.

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Pathology oncology research : POR 2019 Apr;25(2):635-646

Dietary Sea Buckthorn Pomace Induces Beige Adipocyte Formation in Inguinal White Adipose Tissue in Lambs.

Zhang T, Deng B, Zhang R, Qin X, Zhang J, Zhao J
Animals : an open access journal from MDPI 2019 Apr 24;9(4)

A vanillin derivative suppresses the growth of HT29 cells through the Wnt/β-catenin signaling pathway.

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The Choroid Plexus Functions as a Niche for T-Cell Stimulation Within the Central Nervous System.

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Novel Methylselenoesters Induce Programed Cell Death via Entosis in Pancreatic Cancer Cells.

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International journal of molecular sciences 2018 Sep 20;19(10)

Protein-protein interactions reveal key canonical pathways, upstream regulators, interactome domains, and novel targets in ALS.

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Decrease in male mouse fertility by hydrogen sulfide and/or ammonia can Be inheritable.

Zhang W, Zhao Y, Zhang P, Hao Y, Yu S, Min L, Li L, Ma D, Chen L, Yi B, Tang X, Meng Q, Liu L, Wang S, Shen W, Zhang H
Chemosphere 2018 Mar;194:147-157

Src Promotes Metastasis of Human Non-Small Cell Lung Cancer Cells through Fn14-Mediated NF-κB Signaling.

Wang W, Liu F, Wang C, Wang C, Tang Y, Jiang Z
Medical science monitor : international medical journal of experimental and clinical research 2018 Mar 3;24:1282-1294

Effects of mulberry leaf on experimental hyperlipidemia rats induced by high-fat diet.

Huang J, Wang Y, Ying C, Liu L, Lou Z
Experimental and therapeutic medicine 2018 Aug;16(2):547-556

RANKL-induced M1 macrophages are involved in bone formation.

Huang R, Wang X, Zhou Y, Xiao Y
Bone research 2017;5:17019

Restoring diabetes-induced autophagic flux arrest in ischemic/reperfused heart by ADIPOR (adiponectin receptor) activation involves both AMPK-dependent and AMPK-independent signaling.

Wang Y, Liang B, Lau WB, Du Y, Guo R, Yan Z, Gan L, Yan W, Zhao J, Gao E, Koch W, Ma XL
Autophagy 2017;13(11):1855-1869

Pentosan polysulfate inhibits IL-1β-induced iNOS, c-Jun and HIF-1α upregulation in canine articular chondrocytes.

Bwalya EC, Kim S, Fang J, Wijekoon HMS, Hosoya K, Okumura M
PloS one 2017;12(5):e0177144

Alpha-1-antitrypsin suppresses oxidative stress in preeclampsia by inhibiting the p38MAPK signaling pathway: An in vivo and in vitro study.

Feng YL, Yin YX, Ding J, Yuan H, Yang L, Xu JJ, Hu LQ
PloS one 2017;12(3):e0173711

Upregulated Expression of Transient Receptor Potential Cation Channel Subfamily V Receptors in Mucosae of Patients with Oral Squamous Cell Carcinoma and Patients with a History of Alcohol Consumption or Smoking.

Sakakibara A, Sakakibara S, Kusumoto J, Takeda D, Hasegawa T, Akashi M, Minamikawa T, Hashikawa K, Terashi H, Komori T
PloS one 2017;12(1):e0169723

Protective Effects of Curcumin against Sodium Arsenite-induced Ovarian Oxidative Injury in a Mouse Model.

Wang XN, Zhang CJ, Diao HL, Zhang Y
Chinese medical journal 2017 May 5;130(9):1026-1032

Global Reprogramming of Host Kinase Signaling in Response to Fungal Infection.

Pandey A, Ding SL, Qin QM, Gupta R, Gomez G, Lin F, Feng X, Fachini da Costa L, Chaki SP, Katepalli M, Case ED, van Schaik EJ, Sidiq T, Khalaf O, Arenas A, Kobayashi KS, Samuel JE, Rivera GM, Alaniz RC, Sze SH, Qian X, Brown WJ, Rice-Ficht A, Russell WK, Ficht TA, de Figueiredo P
Cell host & microbe 2017 May 10;21(5):637-649.e6

Role of endoplasmic reticulum stress on cisplatin resistance in ovarian carcinoma.

Tian J, Liu R, Qu Q
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Potential biomarkers of DNA replication stress in cancer.

Ren L, Chen L, Wu W, Garribba L, Tian H, Liu Z, Vogel I, Li C, Hickson ID, Liu Y
Oncotarget 2017 Jun 6;8(23):36996-37008

Induction of humoral and cellular immune response to hepatitis B virus (HBV) vaccine can be upregulated by CpG oligonucleotides complexed with Dectin-1 ligand.

Ito H, Ando T, Nakamura M, Ishida H, Kanbe A, Kobiyama K, Yamamoto T, Ishii KJ, Hara A, Seishima M, Ishikawa T
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Effect of Choline on the Composition and Degradation Enzyme of Extracellular Matrix of Mice Chondrocytes Exposed to Fluoride.

Zhao Y, Hao J, Wang J, Wang J
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Microsomal Prostaglandin E Synthase-1 Facilitates an Intercellular Interaction between CD4⁺ T Cells through IL-1β Autocrine Function in Experimental Autoimmune Encephalomyelitis.

Takemiya T, Takeuchi C, Kawakami M
International journal of molecular sciences 2017 Dec 19;18(12)

Minocycline attenuates sevoflurane-induced cell injury via activation of Nrf2.

Tian Y, Wu X, Guo S, Ma L, Huang W, Zhao X
International journal of molecular medicine 2017 Apr;39(4):869-878

Hispidulin induces mitochondrial apoptosis in acute myeloid leukemia cells by targeting extracellular matrix metalloproteinase inducer.

Gao H, Liu Y, Li K, Wu T, Peng J, Jing F
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Osteoclast-derived microRNA-containing exosomes selectively inhibit osteoblast activity.

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Phenotype transformation of immortalized NCM460 colon epithelial cell line by TGF-β1 is associated with chromosome instability.

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NF-κB is involved in the LPS-mediated proliferation and apoptosis of MAC-T epithelial cells as part of the subacute ruminal acidosis response in cows.

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Platelet-rich plasma protects rat chondrocytes from interleukin-1β-induced apoptosis.

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IL-17 Promotes Angiogenic Factors IL-6, IL-8, and Vegf Production via Stat1 in Lung Adenocarcinoma.

Huang Q, Duan L, Qian X, Fan J, Lv Z, Zhang X, Han J, Wu F, Guo M, Hu G, Du J, Chen C, Jin Y
Scientific reports 2016 Nov 7;6:36551

Limb Remote Ischemic Postconditioning Reduces Ischemia-Reperfusion Injury by Inhibiting NADPH Oxidase Activation and MyD88-TRAF6-P38MAP-Kinase Pathway of Neutrophils.

Chen G, Ye X, Zhang J, Tang T, Li L, Lu P, Wu Q, Yu B, Kou J
International journal of molecular sciences 2016 Nov 25;17(12)

Exendin-4 promotes proliferation of adipose-derived stem cells through ERK and JNK signaling pathways.

Zhang Y, Chen S, Liu B, Zhou H, Hu S, Zhou Y, Han T, Chen Y
In vitro cellular & developmental biology. Animal 2016 May;52(5):598-606

Quercetin-Rich Guava (Psidium guajava) Juice in Combination with Trehalose Reduces Autophagy, Apoptosis and Pyroptosis Formation in the Kidney and Pancreas of Type II Diabetic Rats.

Lin CF, Kuo YT, Chen TY, Chien CT
Molecules (Basel, Switzerland) 2016 Mar 10;21(3):334

Effects of Tanshinone IIA on the modulation of miR‑33a and the SREBP‑2/Pcsk9 signaling pathway in hyperlipidemic rats.

Jia L, Song N, Yang G, Ma Y, Li X, Lu R, Cao H, Zhang N, Zhu M, Wang J, Leng X, Cao Y, Du Y, Xu Y
Molecular medicine reports 2016 Jun;13(6):4627-35

Cecropin B Represses CYP3A29 Expression through Activation of the TLR2/4-NF-κB/PXR Signaling Pathway.

Zhou X, Li X, Wang X, Jin X, Shi D, Wang J, Bi D
Scientific reports 2016 Jun 14;6:27876

Characterization of Ovine Dermal Papilla Cell Aggregation.

Sari AR, Rufaut NW, Jones LN, Sinclair RD
International journal of trichology 2016 Jul-Sep;8(3):121-9

Iowa Mutant Apolipoprotein A-I (ApoA-IIowa) Fibrils Target Lysosomes.

Kameyama H, Nakajima H, Nishitsuji K, Mikawa S, Uchimura K, Kobayashi N, Okuhira K, Saito H, Sakashita N
Scientific reports 2016 Jul 28;6:30391

Kidney-specific Sonoporation-mediated Gene Transfer.

Ishida R, Kami D, Kusaba T, Kirita Y, Kishida T, Mazda O, Adachi T, Gojo S
Molecular therapy : the journal of the American Society of Gene Therapy 2016 Feb;24(1):125-34

γ-H2AX/53BP1/pKAP-1 foci and their linear tracks induced by in vitro exposure to radon and its progeny in human peripheral blood lymphocytes.

Ding D, Zhang Y, Wang J, Wang X, Fan D, He L, Zhang X, Gao Y, Li Q, Chen H
Scientific reports 2016 Dec 6;6:38295

KIAA1522 is a novel prognostic biomarker in patients with non-small cell lung cancer.

Liu YZ, Yang H, Cao J, Jiang YY, Hao JJ, Xu X, Cai Y, Wang MR
Scientific reports 2016 Apr 21;6:24786

Electroacupuncture stimulates remodeling of extracellular matrix by inhibiting apoptosis in a rabbit model of disc degeneration.

Huang GF, Zou J, Shi J, Zhang DY, Peng HF, Zhang Q, Gao Y, Wang BY, Zhang TF
Evidence-based complementary and alternative medicine : eCAM 2015;2015:386012

Stereoselective Regulation of P-gp Activity by Clausenamide Enantiomers in Caco-2, KB/KBv and Brain Microvessel Endothelial Cells.

Zhu CJ, Hua F, Zhu XL, Li M, Wang HX, Yu XM, Li Y
PloS one 2015;10(8):e0135866

JNK is required for maintaining the tumor-initiating cell-like properties of acquired chemoresistant human cancer cells.

Liu Y, Zhang X, Wang J, Yang J, Tan WF
Acta pharmacologica Sinica 2015 Sep;36(9):1099-106

Antigen-specific NK cell memory in rhesus macaques.

Reeves RK, Li H, Jost S, Blass E, Li H, Schafer JL, Varner V, Manickam C, Eslamizar L, Altfeld M, von Andrian UH, Barouch DH
Nature immunology 2015 Sep;16(9):927-32

Tumor suppressor NDRG2 inhibits glycolysis and glutaminolysis in colorectal cancer cells by repressing c-Myc expression.

Xu X, Li J, Sun X, Guo Y, Chu D, Wei L, Li X, Yang G, Liu X, Yao L, Zhang J, Shen L
Oncotarget 2015 Sep 22;6(28):26161-76

Dietary NiCl₂ causes G₂/M cell cycle arrest in the broiler's kidney.

Guo H, Cui H, Peng X, Fang J, Zuo Z, Deng J, Wang X, Wu B, Chen K, Deng J
Oncotarget 2015 Nov 3;6(34):35964-77

Hyperbaric Oxygen and Ginkgo Biloba Extract Ameliorate Cognitive and Memory Impairment via Nuclear Factor Kappa-B Pathway in Rat Model of Alzheimer's Disease.

Zhang LD, Ma L, Zhang L, Dai JG, Chang LG, Huang PL, Tian XQ
Chinese medical journal 2015 Nov 20;128(22):3088-93

P62 regulates resveratrol-mediated Fas/Cav-1 complex formation and transition from autophagy to apoptosis.

Zhang J, Ma K, Qi T, Wei X, Zhang Q, Li G, Chiu JF
Oncotarget 2015 Jan 20;6(2):789-801

Possible Role of GADD45γ Methylation in Diffuse Large B-Cell Lymphoma: Does It Affect the Progression and Tissue Involvement?

Barış İC, Caner V, Şen Türk N, Sarı İ, Hacıoğlu S, Doğu MH, Çetin O, Tepeli E, Can Ö, Bağcı G, Keskin A
Turkish journal of haematology : official journal of Turkish Society of Haematology 2015 Dec;32(4):295-303

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Wang G, Yu Z, Zhen Y, Mi T, Shi Y, Wang J, Wang M, Sun S
PloS one 2014;9(6):e100057

Transforming growth factor β-induced superficial zone protein accumulation in the surface zone of articular cartilage is dependent on the cytoskeleton.

McNary SM, Athanasiou KA, Reddi AH
Tissue engineering. Part A 2014 Mar;20(5-6):921-9

Maternal bisphenol a diet induces anxiety-like behavior in female juvenile with neuroimmune activation.

Luo G, Wang S, Li Z, Wei R, Zhang L, Liu H, Wang C, Niu R, Wang J
Toxicological sciences : an official journal of the Society of Toxicology 2014 Aug 1;140(2):364-73

Protective Effects of Lycium barbarum Polysaccharides on Testis Spermatogenic Injury Induced by Bisphenol A in Mice.

Zhang C, Wang A, Sun X, Li X, Zhao X, Li S, Ma A
Evidence-based complementary and alternative medicine : eCAM 2013;2013:690808

Keratinocyte growth factor improves epithelial structure and function in a mouse model of intestinal ischemia/reperfusion.

Cai Y, Wang W, Liang H, Sun L, Teitelbaum DH, Yang H
PloS one 2012;7(9):e44772

Keratinocyte growth factor up-regulates Interleukin-7 expression following intestinal ischemia/reperfusion in vitro and in vivo.

Cai YJ, Wang WS, Liang HY, Sun LH, Teitelbaum DH, Yang H
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Gsdma3 is a new factor needed for TNF-α-mediated apoptosis signal pathway in mouse skin keratinocytes.

Lei M, Bai X, Yang T, Lai X, Qiu W, Yang L, Lian X
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Supportive validation

Submitted by: Bioss (provider)
Main image
Experimental details: Rat lung lysate 30ug, probed (bs-0081R) at 1:200 overnight in 4°C. Followed by conjugation to the secondary antibody (bs-0295G-HRP) at 1:3000 90min in 37°C. Predicted and observed band size: 17kDa,33kD
Sample type: Rat
Other comments: Brain

Supportive validation

Submitted by: Bioss (provider)
Main image
Experimental details: Formalin-fixed and paraffin embedded rat brain tissue labeled with Anti-Caspase-3 Polyclonal Antibody, Unconjugated(bs-0081R) 1:200 followed by conjugation to the secondary antibody and DAB staining
Sample type: Rat
Other comments: Brain

Supportive validation

Submitted by: Bioss (provider)
Main image
Experimental details: Formalin-fixed and paraffin embedded rabbit pancreas tissue labeled with Anti-Caspase-3 Polyclonal Antibody, Unconjugated (bs-0081R) 1:300 followed by conjugation to the secondary antibody and DAB staining
Sample type: Rabbit
Other comments: Pancreas

Supportive validation

Submitted by: Bioss (provider)
Main image
Experimental details: Formalin-fixed and paraffin embedded Human oral squamous cell carcinoma labeled with Anti-Caspase-3 Polyclonal Antibody, Unconjugated (bs-0081R) at 1:200 followed by conjugation to the secondary antibody Goat Anti-Rabbit IgG, PE conjugated(bs-0295G-PE) used at 1:200 dilution for 40 minutes at 37°C and DAPI staining
Sample type: Human