DPABH-16029

antibody from Creative Diagnostics

Targeting: CASP3 apopain, CPP32, CPP32B, Yama

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

DPABH-16029

Provider

Creative Diagnostics

Proper citation

Creative Diagnostics Cat#DPABH-16029, RRID:AB_2513684

Product name

Rabbit Anti-Human CASP3 Polyclonal antibody

Antibody type

Polyclonal

Description

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimers disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.

Reactivity

Human, Mouse, Rat, Hamster, Sheep, Simian

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

50 uL